Ezh2 competes with p53 to license lncRNA Neat1 transcription for inflammasome activation

• Published in: Cell death and differentiation Vol. 29; no. 10; pp. 2009 - 2023
• Main Authors: Yuan, Jia, Zhu, Qingchen, Zhang, Xingli, Wen, Zhenzhen, Zhang, Guiheng, Li, Ni, Pei, Yifei, Wang, Yan, Pei, Siyu, Xu, Jing, Jia, Pan, Peng, Chao, Lu, Wei, Qin, Jun, Cao, Qian, Xiao, Yichuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2022; Nature Publishing Group
• Subjects: 13/21; 13/31; 13/51; 13/95; 45/15; 631/250/256/2177; 631/337/176; 692/420/256/2177; Acetylation; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Chromatin; Deacetylation; Epigenetics; Histone methyltransferase; Inflammasomes; Inflammatory diseases; Life Sciences; Macrophages; Microglia; Non-coding RNA; p53 Protein; SIRT1 protein; Stem Cells; Transcription; Transcription activation; Tumor suppressor genes; Tumors

Inflammasome contributes to the pathogenesis of various inflammatory diseases, but the epigenetic mechanism controlling its activation remains elusive. Here, we found that the histone methyltransferase Ezh2 mediates the activation of multiple types of inflammasomes in macrophages/microglia independe...