Spatially-resolved Brillouin spectroscopy reveals biomechanical abnormalities in mild to advanced keratoconus in vivo

• Published in: Scientific reports Vol. 9; no. 1; p. 7467
• Main Authors: Shao, Peng, Eltony, Amira M., Seiler, Theo G., Tavakol, Behrouz, Pineda, Roberto, Koller, Tobias, Seiler, Theo, Yun, Seok-Hyun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.05.2019; Nature Publishing Group
• Subjects: 140/125; 639/624/1111/55; 692/699/3161; Adult; Biomechanics; Cornea; Diagnostic Techniques, Ophthalmological; Disease detection; Elastic Modulus; Eye diseases; Eye surgery; Female; Humanities and Social Sciences; Humans; Keratoconus; Keratoconus - diagnosis; Male; Mechanical properties; Microscopy; Middle Aged; multidisciplinary; Science; Science (multidisciplinary); Spatial discrimination; Spectroscopy; Spectrum Analysis - methods

Mounting evidence connects the biomechanical properties of tissues to the development of eye diseases such as keratoconus, a disease in which the cornea thins and bulges into a conical shape. However, measuring biomechanical changes in vivo with sufficient sensitivity for disease detection has prove...