Immunogenicity and safety of routine vaccines in children and adolescents with rheumatic diseases on immunosuppressive treatment — a systematic review

• Published in: European journal of pediatrics Vol. 181; no. 4; pp. 1329 - 1362
• Main Authors: Keller, Michèle, Pittet, Laure F., Zimmermann, Petra
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2022; Springer Nature B.V
• Subjects: Adolescent; Adolescents; Age differences; Arthritis; Child; Children; Humans; Immunization Schedule; Immunogenicity; Immunosuppressive Agents - adverse effects; Medicine; Medicine & Public Health; Pediatrics; Review; Reviews; Rheumatic diseases; Rheumatic Diseases - drug therapy; Rheumatic Diseases - etiology; Safety; Seroconversion; Systematic review; Systemic lupus erythematosus; Teenagers; Vaccination; Vaccines; Vaccines, Attenuated - adverse effects; Juvenile dermatomyositis; Disease activity; Humoral response; Systemic lupus erythematosus; Juvenile arthritis; Immunisation; Antibodies; DMARD; Juvenile autoimmune rheumatic diseases

The immunogenicity of vaccines in children with juvenile autoimmune rheumatic diseases (JARDs) can be reduced, there are additional safety concerns around vaccination, and there is a potential for worsening in disease activity. In this systematic review, we summarise studies that investigated the im...