Podocyte-targeted Heme Oxygenase (HO)-1 overexpression exacerbates age-related pathology in the rat kidney

• Published in: Scientific reports Vol. 10; no. 1; p. 5719
• Main Authors: Poulaki, Elpida, Detsika, Maria G., Fourtziala, Eythimia, Lianos, Elias A., Gakiopoulou, Hariklia
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.03.2020; Nature Publishing Group
• Subjects: 13; 13/51; 14; 14/28; 14/63; 59; 631/337/1427/2566; 692/4022/1585/104; 8-Hydroxydeoxyguanosine; 82; 96; Age; Aging; Aging - metabolism; Aging - pathology; Albuminuria - metabolism; Albuminuria - pathology; Animals; Atrophy; DNA damage; Epithelial cells; Fibrosis; Glomerulosclerosis, Focal Segmental - metabolism; Glomerulosclerosis, Focal Segmental - pathology; Heme; Heme oxygenase (decyclizing); Heme Oxygenase-1 - metabolism; Hemosiderin - metabolism; Humanities and Social Sciences; Iron; Kidney - metabolism; Kidney - pathology; Kidneys; L-Lactate dehydrogenase; Lactic acid; Lesions; multidisciplinary; Oxygenase; Pathology; Podocytes - metabolism; Podocytes - pathology; Rats; Science; Science (multidisciplinary); Spleen

Although Heme Oxygenase-1 (HO-1) induction in various forms of kidney injury is protective, its role in age-related renal pathology is unknown. In the ageing kidney there is nephron loss and lesions of focal glomerulosclerosis, interstitial fibrosis, tubular atrophy and arteriolosclerosis. Underlyin...