Adenosine receptors as promising targets for the management of ocular diseases

• Published in: Medicinal chemistry research Vol. 30; no. 2; pp. 353 - 370
• Main Authors: Spinozzi, Eleonora, Baldassarri, Cecilia, Acquaticci, Laura, Del Bello, Fabio, Grifantini, Mario, Cappellacci, Loredana, Riccardo, Petrelli
• Format: Journal Article
• Language: English
• Published: New York Springer US 2021; Springer Nature B.V
• Subjects: Adenosine; Adenosine receptors; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Drug development; Drugs; Eye diseases; Inorganic Chemistry; Medicinal Chemistry; Modulators; Nucleosides; Pharmacology/Toxicology; Receptors; Review; Review Article; Glaucoma; AR; A; Dry eye; Adenosine receptors (A; Retinal inflammation; Ocular diseases; Intraocular pressure; Adenosine receptors (A1AR; A2BAR; A2AAR; A3AR

The ocular drug discovery arena has undergone a significant improvement in the last few years culminating in the FDA approvals of 8 new drugs. However, despite a large number of drugs, generics, and combination products available, it remains an urgent need to find breakthrough strategies and therapi...