Exploring the mechanism of enterotoxicity mediated by the microbiome-butyrate-PPAR axis in podophyllotoxin through the toxicological evidence chain (TEC) concept - Duan, Jiajia; Du, Peipei; Jiang, Tao; Ma, Xiao; Sun, Jiaxing; Liang, Jin; Wang, Jingjing; Liu, Chuanxin (Ecotoxicology and environmental safety, 2024)
Keywords: Animals; co-occurrence network; enterotoxicity; Gastrointestinal Microbiome - drug effects; gut microbiota; Male; metabolome; Microbiota - drug effects; Peroxisome Proliferator-Activated Receptors - metabolism; podophyllotoxin; Podophyllotoxin - toxicity; PPAR gamma - metabolism; Rats; Rats, Sprague-Dawley; transcriptome; PCoA; BSFS; transcriptome; LDA; SPF; IBD; WGCNA; BP; SD; podophyllotoxin; enterotoxicity; DEGs; PPT; AOE; KEGG; MF; COG; CC; HIE; GO; co-occurrence network; gut microbiota; ET; PCA; LEfSe; TEC; DAO; TEE; UPLC-MS/MS; SCFAs; VIP; HE; metabolome; IPE