Airway re-narrowing following deep inspiration in asthmatic and nonasthmatic subjects

• Published in: The European respiratory journal Vol. 22; no. 1; pp. 62 - 68
• Main Authors: Salome, C.M, Thorpe, C.W, Diba, C, Brown, N.J, Berend, N, King, G.G
• Format: Journal Article
• Language: English
• Published: Leeds Eur Respiratory Soc 01.07.2003; Maney
• Subjects: Adult; Airway Resistance - drug effects; Airway Resistance - physiology; Asthma - physiopathology; Biological and medical sciences; Bronchial Provocation Tests; Female; Forced Expiratory Volume - drug effects; Humans; Inspiratory Capacity - drug effects; Investigative techniques of respiratory function; Investigative techniques, diagnostic techniques (general aspects); Linear Models; Male; Medical sciences; Methacholine Chloride - pharmacology; Middle Aged; Muscle, Smooth - drug effects; Muscle, Smooth - physiopathology; Spirometry; Tidal Volume; Human; Airway re-narrowing asthma deep inspiration forced oscillation technique velocity of shortening; Lung function; Pathophysiology; Respiratory disease; Exploration; Obstructive pulmonary disease; Forced inspiration; Asthma

After bronchoconstriction, deep inspiration (DI) causes dilatation followed by airway re-narrowing. Re-narrowing may be faster in asthmatic than nonasthmatic subjects. This study investigated the relationship between re-narrowing and the magnitude of both DI-induced dilatation and the volume-depende...