Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers
To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjec...
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| Published in | Scientific reports Vol. 10; no. 1; p. 20794 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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London
Nature Publishing Group UK
27.11.2020
Nature Publishing Group |
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| Online Access | Get full text |
| ISSN | 2045-2322 2045-2322 |
| DOI | 10.1038/s41598-020-77882-6 |
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| Abstract | To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s,
p
< 0.001, 0.08 vs. 0.09 m/s,
p
< 0.01 and 0.13 vs. 0.14 m/s,
p
= 0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s,
p
= 0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers. |
|---|---|
| AbstractList | To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s,
p
< 0.001, 0.08 vs. 0.09 m/s,
p
< 0.01 and 0.13 vs. 0.14 m/s,
p
= 0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s,
p
= 0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers. To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p < 0.001, 0.08 vs. 0.09 m/s, p < 0.01 and 0.13 vs. 0.14 m/s, p = 0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p = 0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers. To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p < 0.001, 0.08 vs. 0.09 m/s, p < 0.01 and 0.13 vs. 0.14 m/s, p = 0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p = 0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers. To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p < 0.001, 0.08 vs. 0.09 m/s, p < 0.01 and 0.13 vs. 0.14 m/s, p = 0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p = 0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers.To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p < 0.001, 0.08 vs. 0.09 m/s, p < 0.01 and 0.13 vs. 0.14 m/s, p = 0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p = 0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers. |
| ArticleNumber | 20794 |
| Author | Pešl, Martin Máchal, Jan Panovský, Roman Kincl, Vladimír Juříková, Lenka Masárová, Lucia Haberlová, Jana |
| Author_xml | – sequence: 1 givenname: Vladimír surname: Kincl fullname: Kincl, Vladimír email: vladimir.kincl@fnusa.cz organization: Department of Internal Medicine/Cardiology, Faculty of Medicine, St. Anne’s University Hospital, Masaryk University, International Clinical Research Center, St. Anne’s University Hospital – sequence: 2 givenname: Roman surname: Panovský fullname: Panovský, Roman organization: Department of Internal Medicine/Cardiology, Faculty of Medicine, St. Anne’s University Hospital, Masaryk University, International Clinical Research Center, St. Anne’s University Hospital – sequence: 3 givenname: Martin surname: Pešl fullname: Pešl, Martin organization: Department of Internal Medicine/Cardiology, Faculty of Medicine, St. Anne’s University Hospital, Masaryk University, International Clinical Research Center, St. Anne’s University Hospital, Department of Biology, Faculty of Medicine, Masaryk University – sequence: 4 givenname: Jan surname: Máchal fullname: Máchal, Jan organization: International Clinical Research Center, St. Anne’s University Hospital, Department of Pathological Physiology, Faculty of Medicine, Masaryk University – sequence: 5 givenname: Lenka surname: Juříková fullname: Juříková, Lenka organization: Department of Pediatric Neurology, Faculty of Medicine, University Hospital Brno, Masaryk University – sequence: 6 givenname: Jana surname: Haberlová fullname: Haberlová, Jana organization: Department of Pediatric Neurology, Second Faculty of Medicine, University Hospital Motol, Charles University – sequence: 7 givenname: Lucia surname: Masárová fullname: Masárová, Lucia organization: Department of Internal Medicine/Cardiology, Faculty of Medicine, St. Anne’s University Hospital, Masaryk University, International Clinical Research Center, St. Anne’s University Hospital |
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| Cites_doi | 10.1093/ejechocard/jep164 10.5582/irdr.2018.01003 10.3390/cells8010053 10.1016/S0002-9149(02)02495-5 10.1186/s13023-019-1257-4 10.1093/ejechocard/jep007 10.1042/CS20030153 10.1212/01.wnl.0000188909.89849.59 10.1186/1532-429X-11-40 10.1093/hmg/ddv055 10.1016/j.echo.2006.02.003 10.1016/S0960-8966(98)00071-6 10.1161/01.CIR.104.2.128 10.1016/j.jacc.2007.01.078 10.5966/sctm.2012-0174 10.1016/j.pediatrneurol.2015.11.004 10.1016/j.jacc.2004.09.059 10.1016/S0735-1097(97)00344-6 10.1001/jama.1996.03530410049032 10.1016/S0735-1097(97)88335-0 10.1016/j.hlc.2012.11.015 10.1002/mus.25445 10.1016/j.nmd.2014.03.008 10.1146/annurev.med.58.011706.144703 10.1093/ehjci/jev161 10.1186/s13023-018-0986-0 10.1007/s004310100812 10.1155/2020/8396429 |
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| Title | Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers |
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