Effects of GADL1 overexpression on cell migration and the associated morphological changes

• Published in: Scientific reports Vol. 9; no. 1; p. 5298
• Main Authors: Wu, Tai-Na, Chen, Chih-Ken, Liu, I-Chao, Wu, Lawrence Shih-Hsin, Cheng, Andrew Tai-Ann
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.03.2019; Nature Publishing Group
• Subjects: 14; 14/63; 38/109; 38/61; 38/77; 38/90; 631/337/2019; 631/80/84; Antimanic Agents - pharmacology; Antimanic Agents - therapeutic use; Asian Continental Ancestry Group - genetics; Bipolar disorder; Bipolar Disorder - drug therapy; Bipolar Disorder - genetics; Carboxy-Lyases - genetics; Carboxy-Lyases - metabolism; Cell adhesion & migration; Cell Line, Tumor; Cell migration; Cell Movement - drug effects; Cell Movement - genetics; Chemokine CCL2 - metabolism; Drug Resistance - genetics; Glutamate decarboxylase; Humanities and Social Sciences; Humans; Lithium; Lithium - pharmacology; Lithium - therapeutic use; Monocyte chemoattractant protein 1; Morphology; multidisciplinary; Neurons - physiology; Patients; Polymorphism, Single Nucleotide; Science; Science (multidisciplinary); Single-nucleotide polymorphism; Taurine

Lithium has been used for maintenance treatment of bipolar disorder, but drug response varies among patients. Single-nucleotide polymorphisms in glutamate decarboxylase–like protein 1 ( GADL1 ) are found to be associated with lithium response in Han Chinese bipolar patients. In this study, we assess...