Bone marrow mesenchymal stem cells from patients with aplastic anemia maintain functional and immune properties and do not contribute to the pathogenesis of the disease

• Published in: Haematologica (Roma) Vol. 99; no. 7; pp. 1168 - 1175
• Main Authors: Bueno, Clara, Roldan, Mar, Anguita, Eduardo, Romero-Moya, Damia, Martín-Antonio, Beatriz, Rosu-Myles, Michael, del Cañizo, Consuelo, Campos, Francisco, García, Regina, Gómez-Casares, Maite, Fuster, Jose Luis, Jurado, Manuel, Delgado, Mario, Menendez, Pablo
• Format: Journal Article
• Language: English
• Published: Italy Ferrata Storti Foundation 01.07.2014
• Subjects: Adolescent; Adult; Aged; Anemia, Aplastic - diagnosis; Anemia, Aplastic - etiology; Anemia, Aplastic - immunology; Anemia, Aplastic - metabolism; Antigens, CD34 - metabolism; Case-Control Studies; Cell Differentiation; Cells, Cultured; Child; Coculture Techniques; Female; Fetal Blood - cytology; Graft Survival; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Humans; Immunomodulation; Immunophenotyping; Male; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - immunology; Mesenchymal Stromal Cells - metabolism; Middle Aged; Phenotype; Young Adult

Aplastic anemia is a life-threatening bone marrow failure disorder characterized by peripheral pancytopenia and marrow hypoplasia. The majority of cases of aplastic anemia remain idiopathic, although hematopoietic stem cell deficiency and impaired immune responses are hallmarks underlying the bone m...