Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice

• Published in: Scientific reports Vol. 9; no. 1; p. 1012
• Main Authors: Joseph, Biju, Shimojo, Guilherme, Li, Zhifeng, Thompson-Bonilla, Maria del Rocio, Shah, Roshan, Kanashiro, Alexandre, Salgado, Helio C., Ulloa, Luis
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.01.2019; Nature Publishing Group
• Subjects: 13/21; 631/250/256/1980; 64/60; 692/308/1426; 96; 96/31; Adrenal glands; Animals; Blood pressure; Clinical trials; Cytokines - metabolism; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - metabolism; Dopamine; Dopamine - metabolism; Dopamine Agonists - pharmacology; Dopamine receptors; Fasting - metabolism; Glucose; Glucose - physiology; Humanities and Social Sciences; Hyperglycemia; Hyperglycemia - metabolism; Immune response; Inflammation; Inflammation - metabolism; Insulin - metabolism; Male; Metabolism; Mice; Mice, Inbred C57BL; multidisciplinary; Science; Science (multidisciplinary); Sepsis; Sepsis - metabolism; Tumor necrosis factor; Vagus Nerve

Sepsis is a leading cause of death in hospitalized patients. Many experimental treatments may have failed in clinical trials for sepsis, in part, because they focused on immune responses of healthy animals that did not mimic the metabolic settings of septic patients. Epidemiological studies show an...