Establishment and characterization of a novel lung cell line derived from the common bottlenose dolphin

• Published in: In vitro cellular & developmental biology. Animal Vol. 60; no. 1; pp. 98 - 105
• Main Authors: Tashiro, Kaede, Hikobe, Kyosuke, Segawa, Takao, Suzuki, Miwa, Maeda, Ken, Itou, Takuya
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2024; Society for In Vitro Biology
• Subjects: Animal Genetics and Genomics; Animals; Antigen T (large); antigens; Aquatic mammals; Biological properties; Biological samples; Biomedical and Life Sciences; Bottle-Nosed Dolphin - metabolism; Bottle-Nosed Dolphin - virology; Cell Biology; Cell Culture; Cell Line; cell lines; Cytology; Developmental Biology; Diving behavior; Dolphins; fetal bovine serum; Gene expression; genes; Immortalization; Immune response; Immune system; Immunostimulation; Interferon; interferons; Life Sciences; Lung; Lungs; Macaca mulatta polyomavirus 1; Marine mammals; Morphology; Pathogenesis; Polyinosinic:polycytidylic acid; Proteins; Respiratory diseases; Respiratory physiology; Respiratory system; Respiratory Tract Diseases; Stem Cells; TLR3 protein; TLR4 protein; Toll-like receptor 3; Toll-like receptor 4; Toll-like receptors; tumor necrosis factor-alpha; Tumor necrosis factor-TNF; Tursiops truncatus; Viral infections; SV40; Cell culture; Cell line; Bottlenose dolphin; Lung

Cetaceans are specialized marine mammals with a unique respiratory system adapted for diving behavior. Furthermore, respiratory diseases are commonly observed in these mammals. Nevertheless, much of their respiratory physiology remains unknown due to the limited supply and poor quality of their biol...