Analysis of the receptor BCMA as a biomarker in systemic lupus erythematosus patients

• Published in: Scientific reports Vol. 10; no. 1; p. 6236
• Main Authors: Salazar-Camarena, Diana Celeste, Palafox-Sánchez, Claudia Azucena, Cruz, Alvaro, Marín-Rosales, Miguel, Muñoz-Valle, José Francisco
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.04.2020; Nature Publishing Group
• Subjects: 13/21; 13/31; 631/250; 692/4023; 692/53/2422; 82/1; Adolescent; Adult; Aged; APRIL protein; Autoimmune diseases; B-Cell Activating Factor - blood; B-Cell Maturation Antigen - blood; Biomarkers; Biomarkers - blood; BLyS protein; Case-Control Studies; DNA-Binding Proteins - blood; Female; Healthy Volunteers; Humanities and Social Sciences; Humans; Lupus; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - diagnosis; Male; Middle Aged; multidisciplinary; Patients; Plasma cells; Predictive Value of Tests; Prospective Studies; Proteolysis; Reference Values; Science; Science (multidisciplinary); Serum levels; Systemic lupus erythematosus; Transcription Factors - blood; Young Adult

B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) play central roles in B cell development and maturation. Soluble forms of their receptors can be generated by proteolytic cleavage; however, their physiological and clinical roles are unknown. This study aimed to assess the...