Effects of Preservative-free 3% Diquafosol in Patients with Pre-existing Dry Eye Disease after Cataract Surgery: A Randomized Clinical Trial

Dry eye disease (DED) after cataract surgery has become a critical concern, and various therapeutic options have been developed. Recently, preservative-free diquafosol ophthalmic solution has been introduced; however, its therapeutic effect on DED after cataract surgery has not been reported. We inv...

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Published inScientific reports Vol. 9; no. 1; pp. 12659 - 9
Main Authors Jun, Ikhyun, Choi, Seonghee, Lee, Geun Young, Choi, Young Joon, Lee, Hyung Keun, Kim, Eung Kweon, Seo, Kyoung Yul, Kim, Tae-im
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 02.09.2019
Nature Publishing Group
Subjects
692/1807/1482
692/700/565/1436
Aged
Cataract Extraction - adverse effects
Cataracts
Cornea
Dry Eye Syndromes - drug therapy
Dry Eye Syndromes - physiopathology
Eye
Eye diseases
Eye surgery
Female
Humanities and Social Sciences
Humans
Male
Meibomian Glands - drug effects
Meibomian Glands - physiopathology
multidisciplinary
Patients
Polyphosphates - pharmacology
Polyphosphates - therapeutic use
Preservatives
Preservatives, Pharmaceutical - therapeutic use
Science
Science (multidisciplinary)
Surgery
Uracil Nucleotides - pharmacology
Uracil Nucleotides - therapeutic use
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-019-49159-0

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Abstract Dry eye disease (DED) after cataract surgery has become a critical concern, and various therapeutic options have been developed. Recently, preservative-free diquafosol ophthalmic solution has been introduced; however, its therapeutic effect on DED after cataract surgery has not been reported. We investigated the efficacy of preservative-free diquafosol in patients with pre-existing DED after cataract surgery. We divided subjects who were diagnosed with DED and scheduled to undergo cataract surgery, into 3 groups (preservative-free diquafosol, group 1; preservative-containing diquafosol, group 2; preservative-free hyaluronate, group 3), and each eye drops was administered 6 times daily after surgery. Tear break up time (TBUT), Ocular Surface Disease Index (OSDI), corneal staining score, lid margin abnormality, and meibum quality improved over time in group 1. Groups 1 and 2 had significantly superior TBUT, meibomian gland dysfunction grade, and meibomian gland expressibility throughout the study period than group 3. Meibum quality of group 1 was significantly better than group 2 at 1 and 3 months after surgery. Preservative-free diquafosol showed better efficacy in treating DED after cataract surgery than preservative-containing diquafosol or preservative-free hyaluronate. Preservative-free diquafosol may serve as a reliable option for the management of patients with pre-existing DED after phacoemulsification.
AbstractList Dry eye disease (DED) after cataract surgery has become a critical concern, and various therapeutic options have been developed. Recently, preservative-free diquafosol ophthalmic solution has been introduced; however, its therapeutic effect on DED after cataract surgery has not been reported. We investigated the efficacy of preservative-free diquafosol in patients with pre-existing DED after cataract surgery. We divided subjects who were diagnosed with DED and scheduled to undergo cataract surgery, into 3 groups (preservative-free diquafosol, group 1; preservative-containing diquafosol, group 2; preservative-free hyaluronate, group 3), and each eye drops was administered 6 times daily after surgery. Tear break up time (TBUT), Ocular Surface Disease Index (OSDI), corneal staining score, lid margin abnormality, and meibum quality improved over time in group 1. Groups 1 and 2 had significantly superior TBUT, meibomian gland dysfunction grade, and meibomian gland expressibility throughout the study period than group 3. Meibum quality of group 1 was significantly better than group 2 at 1 and 3 months after surgery. Preservative-free diquafosol showed better efficacy in treating DED after cataract surgery than preservative-containing diquafosol or preservative-free hyaluronate. Preservative-free diquafosol may serve as a reliable option for the management of patients with pre-existing DED after phacoemulsification.
Dry eye disease (DED) after cataract surgery has become a critical concern, and various therapeutic options have been developed. Recently, preservative-free diquafosol ophthalmic solution has been introduced; however, its therapeutic effect on DED after cataract surgery has not been reported. We investigated the efficacy of preservative-free diquafosol in patients with pre-existing DED after cataract surgery. We divided subjects who were diagnosed with DED and scheduled to undergo cataract surgery, into 3 groups (preservative-free diquafosol, group 1; preservative-containing diquafosol, group 2; preservative-free hyaluronate, group 3), and each eye drops was administered 6 times daily after surgery. Tear break up time (TBUT), Ocular Surface Disease Index (OSDI), corneal staining score, lid margin abnormality, and meibum quality improved over time in group 1. Groups 1 and 2 had significantly superior TBUT, meibomian gland dysfunction grade, and meibomian gland expressibility throughout the study period than group 3. Meibum quality of group 1 was significantly better than group 2 at 1 and 3 months after surgery. Preservative-free diquafosol showed better efficacy in treating DED after cataract surgery than preservative-containing diquafosol or preservative-free hyaluronate. Preservative-free diquafosol may serve as a reliable option for the management of patients with pre-existing DED after phacoemulsification.Dry eye disease (DED) after cataract surgery has become a critical concern, and various therapeutic options have been developed. Recently, preservative-free diquafosol ophthalmic solution has been introduced; however, its therapeutic effect on DED after cataract surgery has not been reported. We investigated the efficacy of preservative-free diquafosol in patients with pre-existing DED after cataract surgery. We divided subjects who were diagnosed with DED and scheduled to undergo cataract surgery, into 3 groups (preservative-free diquafosol, group 1; preservative-containing diquafosol, group 2; preservative-free hyaluronate, group 3), and each eye drops was administered 6 times daily after surgery. Tear break up time (TBUT), Ocular Surface Disease Index (OSDI), corneal staining score, lid margin abnormality, and meibum quality improved over time in group 1. Groups 1 and 2 had significantly superior TBUT, meibomian gland dysfunction grade, and meibomian gland expressibility throughout the study period than group 3. Meibum quality of group 1 was significantly better than group 2 at 1 and 3 months after surgery. Preservative-free diquafosol showed better efficacy in treating DED after cataract surgery than preservative-containing diquafosol or preservative-free hyaluronate. Preservative-free diquafosol may serve as a reliable option for the management of patients with pre-existing DED after phacoemulsification.
ArticleNumber 12659
Author Lee, Geun Young
Choi, Seonghee
Lee, Hyung Keun
Choi, Young Joon
Kim, Eung Kweon
Seo, Kyoung Yul
Jun, Ikhyun
Kim, Tae-im
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R Arita (49159_CR37) 2009; 116
J Baek (49159_CR13) 2016; 41
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Snippet Dry eye disease (DED) after cataract surgery has become a critical concern, and various therapeutic options have been developed. Recently, preservative-free...
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SubjectTerms 692/1807/1482
692/700/565/1436
Aged
Cataract Extraction - adverse effects
Cataracts
Cornea
Dry Eye Syndromes - drug therapy
Dry Eye Syndromes - physiopathology
Eye
Eye diseases
Eye surgery
Female
Humanities and Social Sciences
Humans
Male
Meibomian Glands - drug effects
Meibomian Glands - physiopathology
multidisciplinary
Patients
Polyphosphates - pharmacology
Polyphosphates - therapeutic use
Preservatives
Preservatives, Pharmaceutical - therapeutic use
Science
Science (multidisciplinary)
Surgery
Uracil Nucleotides - pharmacology
Uracil Nucleotides - therapeutic use
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Title Effects of Preservative-free 3% Diquafosol in Patients with Pre-existing Dry Eye Disease after Cataract Surgery: A Randomized Clinical Trial
URI https://link.springer.com/article/10.1038/s41598-019-49159-0
https://www.ncbi.nlm.nih.gov/pubmed/31477748
https://www.proquest.com/docview/2283282896
https://www.proquest.com/docview/2283996025
https://pubmed.ncbi.nlm.nih.gov/PMC6718409
Volume 9
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