Retinal artery occlusion is associated with compositional and functional shifts in the gut microbiome and altered trimethylamine-N-oxide levels

• Published in: Scientific reports Vol. 9; no. 1; pp. 15303 - 11
• Main Authors: Zysset-Burri, Denise C., Keller, Irene, Berger, Lieselotte E., Neyer, Peter J., Steuer, Christian, Wolf, Sebastian, Zinkernagel, Martin S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.10.2019; Nature Publishing Group
• Subjects: 38; 38/23; 38/39; 38/43; 692/499; 692/699/3161/3175; Abundance; Actinobacteria - isolation & purification; Aged; Arteriosclerosis; Atherosclerosis; Atherosclerosis - metabolism; Bacteroides - isolation & purification; Bifidobacterium - isolation & purification; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Digestive system; Faecalibacterium - isolation & purification; Female; Fluorescein Angiography - methods; Gastrointestinal Microbiome; Gut microbiota; Humanities and Social Sciences; Humans; Intestinal microflora; Lachnospiraceae; Lipid metabolism; Male; Metabolites; Methylamines - metabolism; Microbiomes; Microbiota; multidisciplinary; Occlusion; Relative abundance; Retina; Retinal Artery Occlusion - diagnosis; Retinal Artery Occlusion - metabolism; Retinal Artery Occlusion - microbiology; Risk Factors; Science; Science (multidisciplinary); Tomography, Optical Coherence - methods; Trimethylamine; Trimethylamine-N-oxide

Retinal artery occlusion (RAO) is a sight threatening complication of cardiovascular disease and commonly occurs due to underlying atherosclerosis. As cardiovascular disease and atherosclerosis in particular has been associated with compositional alterations in the gut microbiome, we investigated th...