Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy
Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is characteristic of AD CSF, and predicts cognitive decline. The mechanisms underlying the genotype and apoE level risks are...
Saved in:
| Published in | Molecular psychiatry Vol. 29; no. 2; pp. 211 - 220 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.02.2024
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1359-4184 1476-5578 1476-5578 |
| DOI | 10.1038/s41380-022-01568-w |
Cover
Loading…
| Abstract | Allelic variation to the
APOE
gene confers the greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is characteristic of AD CSF, and predicts cognitive decline. The mechanisms underlying the genotype and apoE level risks are uncertain. Recent fluid and imaging biomarker studies have revealed an unexpected link between apoE and brain iron, which also forecasts disease progression, possibly through ferroptosis, an iron-dependent regulated cell death pathway. Here, we report that apoE is a potent inhibitor of ferroptosis (EC
50
≈ 10 nM; N27 neurons). We demonstrate that apoE signals to activate the PI3K/AKT pathway that then inhibits the autophagic degradation of ferritin (ferritinophagy), thus averting iron-dependent lipid peroxidation. Using postmortem inferior temporal brain cortex tissue from deceased subjects from the Rush Memory and Aging Project (MAP) (
N
= 608), we found that the association of iron with pathologically confirmed clinical Alzheimer’s disease was stronger among those with the adverse
APOE
-ε4 allele. While protection against ferroptosis did not differ between apoE isoforms in vitro, other features of ε4 carriers, such as low abundance of apoE protein and higher levels of polyunsaturated fatty acids (which fuel ferroptosis) could mediate the ε4 allele’s heighted risk of AD. These data support ferroptosis as a putative pathway to explain the major genetic risk associated with late onset AD. |
|---|---|
| AbstractList | Allelic variation to the
APOE
gene confers the greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is characteristic of AD CSF, and predicts cognitive decline. The mechanisms underlying the genotype and apoE level risks are uncertain. Recent fluid and imaging biomarker studies have revealed an unexpected link between apoE and brain iron, which also forecasts disease progression, possibly through ferroptosis, an iron-dependent regulated cell death pathway. Here, we report that apoE is a potent inhibitor of ferroptosis (EC
50
≈ 10 nM; N27 neurons). We demonstrate that apoE signals to activate the PI3K/AKT pathway that then inhibits the autophagic degradation of ferritin (ferritinophagy), thus averting iron-dependent lipid peroxidation. Using postmortem inferior temporal brain cortex tissue from deceased subjects from the Rush Memory and Aging Project (MAP) (
N
= 608), we found that the association of iron with pathologically confirmed clinical Alzheimer’s disease was stronger among those with the adverse
APOE
-ε4 allele. While protection against ferroptosis did not differ between apoE isoforms in vitro, other features of ε4 carriers, such as low abundance of apoE protein and higher levels of polyunsaturated fatty acids (which fuel ferroptosis) could mediate the ε4 allele’s heighted risk of AD. These data support ferroptosis as a putative pathway to explain the major genetic risk associated with late onset AD. Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer's disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is characteristic of AD CSF, and predicts cognitive decline. The mechanisms underlying the genotype and apoE level risks are uncertain. Recent fluid and imaging biomarker studies have revealed an unexpected link between apoE and brain iron, which also forecasts disease progression, possibly through ferroptosis, an iron-dependent regulated cell death pathway. Here, we report that apoE is a potent inhibitor of ferroptosis (EC50 ≈ 10 nM; N27 neurons). We demonstrate that apoE signals to activate the PI3K/AKT pathway that then inhibits the autophagic degradation of ferritin (ferritinophagy), thus averting iron-dependent lipid peroxidation. Using postmortem inferior temporal brain cortex tissue from deceased subjects from the Rush Memory and Aging Project (MAP) (N = 608), we found that the association of iron with pathologically confirmed clinical Alzheimer's disease was stronger among those with the adverse APOE-ε4 allele. While protection against ferroptosis did not differ between apoE isoforms in vitro, other features of ε4 carriers, such as low abundance of apoE protein and higher levels of polyunsaturated fatty acids (which fuel ferroptosis) could mediate the ε4 allele's heighted risk of AD. These data support ferroptosis as a putative pathway to explain the major genetic risk associated with late onset AD.Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer's disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is characteristic of AD CSF, and predicts cognitive decline. The mechanisms underlying the genotype and apoE level risks are uncertain. Recent fluid and imaging biomarker studies have revealed an unexpected link between apoE and brain iron, which also forecasts disease progression, possibly through ferroptosis, an iron-dependent regulated cell death pathway. Here, we report that apoE is a potent inhibitor of ferroptosis (EC50 ≈ 10 nM; N27 neurons). We demonstrate that apoE signals to activate the PI3K/AKT pathway that then inhibits the autophagic degradation of ferritin (ferritinophagy), thus averting iron-dependent lipid peroxidation. Using postmortem inferior temporal brain cortex tissue from deceased subjects from the Rush Memory and Aging Project (MAP) (N = 608), we found that the association of iron with pathologically confirmed clinical Alzheimer's disease was stronger among those with the adverse APOE-ε4 allele. While protection against ferroptosis did not differ between apoE isoforms in vitro, other features of ε4 carriers, such as low abundance of apoE protein and higher levels of polyunsaturated fatty acids (which fuel ferroptosis) could mediate the ε4 allele's heighted risk of AD. These data support ferroptosis as a putative pathway to explain the major genetic risk associated with late onset AD. Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is characteristic of AD CSF, and predicts cognitive decline. The mechanisms underlying the genotype and apoE level risks are uncertain. Recent fluid and imaging biomarker studies have revealed an unexpected link between apoE and brain iron, which also forecasts disease progression, possibly through ferroptosis, an iron-dependent regulated cell death pathway. Here, we report that apoE is a potent inhibitor of ferroptosis (EC50 ≈ 10 nM; N27 neurons). We demonstrate that apoE signals to activate the PI3K/AKT pathway that then inhibits the autophagic degradation of ferritin (ferritinophagy), thus averting iron-dependent lipid peroxidation. Using postmortem inferior temporal brain cortex tissue from deceased subjects from the Rush Memory and Aging Project (MAP) (N = 608), we found that the association of iron with pathologically confirmed clinical Alzheimer’s disease was stronger among those with the adverse APOE-ε4 allele. While protection against ferroptosis did not differ between apoE isoforms in vitro, other features of ε4 carriers, such as low abundance of apoE protein and higher levels of polyunsaturated fatty acids (which fuel ferroptosis) could mediate the ε4 allele’s heighted risk of AD. These data support ferroptosis as a putative pathway to explain the major genetic risk associated with late onset AD. Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is characteristic of AD CSF, and predicts cognitive decline. The mechanisms underlying the genotype and apoE level risks are uncertain. Recent fluid and imaging biomarker studies have revealed an unexpected link between apoE and brain iron, which also forecasts disease progression, possibly through ferroptosis, an iron-dependent regulated cell death pathway. Here, we report that apoE is a potent inhibitor of ferroptosis (EC 50 ≈10 nM; N27 neurons). We demonstrate that apoE signals to activate the PI3K/AKT pathway that then inhibits the autophagic degradation of ferritin (ferritinophagy), thus averting iron-dependent lipid peroxidation. Using postmortem inferior temporal brain cortex tissue from deceased subjects from the Rush Memory and Aging Project (MAP) (N=608), we found that the association of iron with pathologically confirmed clinical Alzheimer’s disease that was stronger among those with the adverse APOE -ε4 allele. While protection against ferroptosis did not differ between apoE isoforms in vitro , other features of ε4 carriers, such as low abundance of apoE protein and higher levels of polyunsaturated fatty acids (which fuel ferroptosis) could mediate the ε4 allele’s heighted risk of AD. These data support ferroptosis as a putative pathway to explain the major genetic risk associated with late onset AD. Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer's disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is characteristic of AD CSF, and predicts cognitive decline. The mechanisms underlying the genotype and apoE level risks are uncertain. Recent fluid and imaging biomarker studies have revealed an unexpected link between apoE and brain iron, which also forecasts disease progression, possibly through ferroptosis, an iron-dependent regulated cell death pathway. Here, we report that apoE is a potent inhibitor of ferroptosis (EC ≈ 10 nM; N27 neurons). We demonstrate that apoE signals to activate the PI3K/AKT pathway that then inhibits the autophagic degradation of ferritin (ferritinophagy), thus averting iron-dependent lipid peroxidation. Using postmortem inferior temporal brain cortex tissue from deceased subjects from the Rush Memory and Aging Project (MAP) (N = 608), we found that the association of iron with pathologically confirmed clinical Alzheimer's disease was stronger among those with the adverse APOE-ε4 allele. While protection against ferroptosis did not differ between apoE isoforms in vitro, other features of ε4 carriers, such as low abundance of apoE protein and higher levels of polyunsaturated fatty acids (which fuel ferroptosis) could mediate the ε4 allele's heighted risk of AD. These data support ferroptosis as a putative pathway to explain the major genetic risk associated with late onset AD. |
| Author | Agarwal, Puja Kalinowski, Pawel Ayton, Scott Masaldan, Shashank Lei, Peng Conrad, Marcus Bush, Ashley I. Southon, Adam Schneider, Julie Acevedo, Karla Leurgans, Sue E. Appukuttan, Ambili T. Belaidi, Abdel Ali Portbury, Stuart |
| AuthorAffiliation | 4 Helmholtz Zentrum München, Institute of Metabolism and Cell Death, 85764 Neuherberg, Germany; Pirogov Russian National Research Medical University, Laboratory of Experimental Oncology, Moscow 117997, Russia 2 Department of Neurology and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China 3 Rush Alzheimer Disease Center, Rush University Medical Center, Chicago, USA 1 Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia |
| AuthorAffiliation_xml | – name: 2 Department of Neurology and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China – name: 3 Rush Alzheimer Disease Center, Rush University Medical Center, Chicago, USA – name: 4 Helmholtz Zentrum München, Institute of Metabolism and Cell Death, 85764 Neuherberg, Germany; Pirogov Russian National Research Medical University, Laboratory of Experimental Oncology, Moscow 117997, Russia – name: 1 Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia |
| Author_xml | – sequence: 1 givenname: Abdel Ali orcidid: 0000-0003-0792-8728 surname: Belaidi fullname: Belaidi, Abdel Ali organization: Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne – sequence: 2 givenname: Shashank orcidid: 0000-0003-4960-4983 surname: Masaldan fullname: Masaldan, Shashank organization: Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne – sequence: 3 givenname: Adam surname: Southon fullname: Southon, Adam organization: Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne – sequence: 4 givenname: Pawel surname: Kalinowski fullname: Kalinowski, Pawel organization: Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne – sequence: 5 givenname: Karla surname: Acevedo fullname: Acevedo, Karla organization: Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne – sequence: 6 givenname: Ambili T. surname: Appukuttan fullname: Appukuttan, Ambili T. organization: Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne – sequence: 7 givenname: Stuart surname: Portbury fullname: Portbury, Stuart organization: Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne – sequence: 8 givenname: Peng orcidid: 0000-0001-5652-1962 surname: Lei fullname: Lei, Peng organization: Department of Neurology and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University – sequence: 9 givenname: Puja orcidid: 0000-0002-0274-6653 surname: Agarwal fullname: Agarwal, Puja organization: Rush Alzheimer Disease Center, Rush University Medical Center – sequence: 10 givenname: Sue E. orcidid: 0000-0003-2536-1665 surname: Leurgans fullname: Leurgans, Sue E. organization: Rush Alzheimer Disease Center, Rush University Medical Center – sequence: 11 givenname: Julie surname: Schneider fullname: Schneider, Julie organization: Rush Alzheimer Disease Center, Rush University Medical Center – sequence: 12 givenname: Marcus orcidid: 0000-0003-1140-5612 surname: Conrad fullname: Conrad, Marcus organization: Helmholtz Zentrum München, Institute of Metabolism and Cell Death, Pirogov Russian National Research Medical University, Laboratory of Experimental Oncology – sequence: 13 givenname: Ashley I. orcidid: 0000-0001-8259-9069 surname: Bush fullname: Bush, Ashley I. email: ashley.bush@florey.edu.au organization: Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne – sequence: 14 givenname: Scott orcidid: 0000-0002-3479-2427 surname: Ayton fullname: Ayton, Scott email: scott.ayton@florey.edu.au organization: Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35484240$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UU1PGzEUtBAVJMAf6KFaqRcu2_pz7b1UQlFokZC4wNmyvd7EdGNvbYco_x6HAAUOnPzkNzNv3pspOPTBWwC-IvgDQSJ-JoqIgDXEuIaINaLeHIAJorypGePisNSEtTVFgh6DaUr3EO6a7AgcE0YFxRROwNXFGAY3hjGGbJ2v5tVYCp-HbeX80mmXU9XbGMOYQ3Kp0ttKD8H8dX7x9O-y82FcqsX2FHzp1ZDs2fN7Au4u57ezP_X1ze-r2cV1bSinuS5jseZUI2Op6kmHOtLwrreQGyYaJRBWxGrT9hwZxnAHW9MbwzTUnW2NtuQE_Nrrjmu9sp0pZqMa5BjdSsWtDMrJ9x3vlnIRHmTLGW9bWgTOnwVi-Le2KcuVS8YOg_I2rJPEDROYYI5xgX7_AL0P6-jLepJA1iLUcAEL6ttbR69WXq5cAHgPMDGkFG3_CkFQ7qKU-yhliVI-RSk3hSQ-kIzLKruw28oNn1PJnprKHL-w8b_tT1iPXYm2PA |
| CitedBy_id | crossref_primary_10_1007_s11010_024_05148_0 crossref_primary_10_1016_j_heliyon_2024_e34381 crossref_primary_10_1038_s41392_024_02088_5 crossref_primary_10_1038_s41420_022_01297_7 crossref_primary_10_3389_fphar_2024_1372094 crossref_primary_10_1089_ars_2023_0318 crossref_primary_10_1080_15548627_2024_2319901 crossref_primary_10_1038_s41420_024_02075_3 crossref_primary_10_1038_s41467_025_56711_2 crossref_primary_10_1007_s11684_023_0992_z crossref_primary_10_1038_s41467_024_45165_7 crossref_primary_10_3390_ijms25115904 crossref_primary_10_1007_s11064_024_04152_6 crossref_primary_10_3233_ADR_220075 crossref_primary_10_1038_s41467_023_37437_5 crossref_primary_10_1016_j_bcp_2022_115255 crossref_primary_10_1038_s41593_022_01221_3 crossref_primary_10_3390_ijms25042337 crossref_primary_10_2147_JIR_S503784 crossref_primary_10_1038_s41401_024_01378_6 crossref_primary_10_3390_ijms24076598 crossref_primary_10_1016_j_jnutbio_2023_109339 crossref_primary_10_1007_s00439_024_02641_w crossref_primary_10_1007_s11427_022_2302_5 crossref_primary_10_1007_s13679_024_00600_0 crossref_primary_10_1002_jcp_31087 crossref_primary_10_1021_acschemneuro_3c00343 crossref_primary_10_1111_jnc_15807 crossref_primary_10_1186_s43556_023_00142_2 crossref_primary_10_1016_j_phymed_2024_155463 crossref_primary_10_1038_s41392_024_01969_z crossref_primary_10_1126_sciadv_adp6164 crossref_primary_10_1016_j_biopha_2023_114312 crossref_primary_10_1177_10738584231191743 crossref_primary_10_1016_j_biopha_2023_114930 crossref_primary_10_1016_j_ejphar_2024_176820 crossref_primary_10_1007_s11010_023_04694_3 crossref_primary_10_1016_j_biopha_2023_115419 crossref_primary_10_1136_jnnp_2022_330052 crossref_primary_10_3233_JAD_220643 crossref_primary_10_1016_j_arr_2023_101899 crossref_primary_10_1016_j_trac_2023_117369 crossref_primary_10_1007_s12035_023_03640_0 crossref_primary_10_3233_JAD_240140 crossref_primary_10_1152_physrev_00031_2024 crossref_primary_10_1186_s12943_024_02217_2 crossref_primary_10_2174_0109298665333926240927074528 |
| Cites_doi | 10.1016/j.cell.2012.03.042 10.1016/j.physbeh.2011.04.018 10.1073/pnas.0712145105 10.1093/ajcn/87.2.449 10.1016/j.freeradbiomed.2010.02.016 10.1038/nature13148 10.1101/gad.1256804 10.1016/j.neuroimage.2020.116808 10.1038/nchembio.2238 10.1016/j.jalz.2017.07.754 10.3233/JAD-191017 10.1021/bi000099m 10.1016/j.nbd.2018.12.010 10.1186/1750-1326-2-2 10.1001/jama.2010.1510 10.1212/01.wnl.0000183148.34197.2e 10.1038/cr.2016.95 10.1212/WNL.0b013e318211c352 10.1016/0006-8993(91)91092-F 10.1074/mcp.M112.018861 10.1136/jnnp-2017-316551 10.1523/JNEUROSCI.1972-08.2008 10.18632/aging.101203 10.1097/00001756-199412000-00032 10.1016/j.neurobiolaging.2010.03.020 10.1006/nbdi.1999.0273 10.3233/JAD-151101 10.1016/j.pneurobio.2020.101904 10.1126/sciadv.abf6707 10.1016/S0891-5849(99)00102-1 10.1097/00005053-195308000-00001 10.1038/ncb3064 10.1016/j.neurobiolaging.2005.06.004 10.1038/srep35514 10.1016/j.biopsych.2015.04.005 10.1038/s41392-020-00428-9 10.1097/NEN.0b013e3181cb5af4 10.1016/j.cell.2017.11.048 10.3174/ajnr.A5143 10.1002/1873-3468.13428 10.1016/j.semcancer.2019.03.002 10.1007/s12031-016-0839-z 10.1093/brain/awx137 10.1007/s13311-018-0656-x 10.1111/bph.14881 10.1016/j.molcel.2018.10.042 10.1074/jbc.M204898200 10.1016/j.nbd.2015.06.016 10.1038/s41568-019-0216-7 10.1038/ncomms7760 10.1126/scitranslmed.aaz4564 10.2174/156720512801322663 10.7554/eLife.02523 10.1111/j.1471-4159.1960.tb13369.x 10.3233/JAD-2010-091723 10.1016/j.pep.2011.06.011 10.1093/ajcn/85.4.1103 10.1111/jnc.13425 10.1016/j.nbd.2007.12.007 10.5858/2001-125-0510-CFATAF 10.1017/S0007114513001268 10.1016/j.devcel.2020.06.019 10.1007/s00401-013-1236-0 10.1111/bph.14567 10.1093/hmg/dds296 10.1038/s41380-019-0375-7 10.1001/jamaneurol.2016.4406 10.1212/01.wnl.0000278116.37320.52 10.1148/radiol.2020192541 10.1016/j.chembiol.2018.11.016 10.1002/alz.12282 10.1007/s13311-021-01111-9 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2022 2022. The Author(s). The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2022 – notice: 2022. The Author(s). – notice: The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7TK 7X7 7XB 88E 88G 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2M M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 5PM |
| DOI | 10.1038/s41380-022-01568-w |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Neurosciences Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni) Medical Database Psychology Database Biological Science Database ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE - Academic ProQuest One Psychology MEDLINE |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1476-5578 |
| EndPage | 220 |
| ExternalDocumentID | PMC9757994 35484240 10_1038_s41380_022_01568_w |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: Alzheimer's Association grantid: AARFD-16-442821 funderid: https://doi.org/10.13039/100000957 – fundername: Department of Health | National Health and Medical Research Council (NHMRC) funderid: https://doi.org/10.13039/501100000925 – fundername: NIA NIH HHS grantid: RF1 AG054057 – fundername: NIA NIH HHS grantid: R01 AG054057 – fundername: NIA NIH HHS grantid: R01 AG017917 – fundername: Alzheimer's Association grantid: AARFD-16-442821 |
| GroupedDBID | --- -Q- 0R~ 123 29M 2WC 36B 39C 3V. 4.4 406 53G 70F 7X7 88E 8AO 8FI 8FJ 8R4 8R5 AACDK AANZL AASML AATNV AAYZH AAZLF ABAKF ABAWZ ABDBF ABIVO ABJNI ABLJU ABUWG ABZZP ACAOD ACGFS ACKTT ACPRK ACRQY ACUHS ACZOJ ADBBV ADHDB AEFQL AEJRE AEMSY AENEX AEVLU AEXYK AFBBN AFKRA AFRAH AFSHS AGAYW AGHAI AGQEE AHMBA AHSBF AIGIU AILAN AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF AXYYD AZQEC B0M BAWUL BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI C6C CAG CCPQU COF CS3 DIK DNIVK DPUIP DU5 DWQXO E3Z EAD EAP EBC EBD EBLON EBS EE. EIOEI EJD EMB EMK EMOBN EPL EPS ESX F5P FDQFY FEDTE FERAY FIGPU FIZPM FSGXE FYUFA GNUQQ HCIFZ HMCUK HVGLF HZ~ IAO IHR INH INR IPY ITC IWAJR JSO JZLTJ KQ8 M1P M2M M7P NAO NQJWS O9- OK1 OVD P2P PQQKQ PROAC PSQYO PSYQQ Q2X RNS RNT RNTTT ROL SNX SNYQT SOHCF SOJ SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TEORI TR2 TSG TUS UKHRP ~8M AAYXX ABBRH ABDBE ABFSG ACSTC AEZWR AFDZB AFHIU AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT ABRTQ CGR CUY CVF ECM EIF NPM PJZUB PPXIY PQGLB 7TK 7XB 8FE 8FH 8FK K9. LK8 PKEHL PQEST PQUKI PRINS Q9U 7X8 5PM |
| ID | FETCH-LOGICAL-c474t-4242b74b1ce4af3d1d367dfe07c586a812a3ebc9f71c552d09cfcc5b0bde9cbe3 |
| IEDL.DBID | C6C |
| ISSN | 1359-4184 1476-5578 |
| IngestDate | Thu Aug 21 18:36:20 EDT 2025 Mon Jul 21 10:04:35 EDT 2025 Fri Jul 25 09:11:57 EDT 2025 Mon Jul 21 05:27:38 EDT 2025 Thu Apr 24 23:06:34 EDT 2025 Tue Jul 01 00:21:57 EDT 2025 Fri Feb 21 02:39:30 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | 2022. The Author(s). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c474t-4242b74b1ce4af3d1d367dfe07c586a812a3ebc9f71c552d09cfcc5b0bde9cbe3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Equal contribution AAB, AIB and SA designed and funded the study, contributed to acquisition and analysis of data and wrote the manuscript. SM, AS, PK, KA, ATA, SP, PL, PA, SEL, JS, MC contributed to acquisition and analysis of data and reviewed the manuscript. Authors contributions |
| ORCID | 0000-0003-0792-8728 0000-0002-3479-2427 0000-0002-0274-6653 0000-0003-1140-5612 0000-0003-4960-4983 0000-0003-2536-1665 0000-0001-8259-9069 0000-0001-5652-1962 |
| OpenAccessLink | https://www.nature.com/articles/s41380-022-01568-w |
| PMID | 35484240 |
| PQID | 3059116780 |
| PQPubID | 44096 |
| PageCount | 10 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_9757994 proquest_miscellaneous_2658232722 proquest_journals_3059116780 pubmed_primary_35484240 crossref_primary_10_1038_s41380_022_01568_w crossref_citationtrail_10_1038_s41380_022_01568_w springer_journals_10_1038_s41380_022_01568_w |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2024-02-01 |
| PublicationDateYYYYMMDD | 2024-02-01 |
| PublicationDate_xml | – month: 02 year: 2024 text: 2024-02-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England – name: New York |
| PublicationTitle | Molecular psychiatry |
| PublicationTitleAbbrev | Mol Psychiatry |
| PublicationTitleAlternate | Mol Psychiatry |
| PublicationYear | 2024 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Kagan, Mao, Qu, Angeli, Doll, Croix (CR58) 2017; 13 Samieri, Feart, Proust-Lima, Peuchant, Dartigues, Amieva (CR65) 2011; 32 Toledo, Da, Weiner, Wolk, Xie, Arnold (CR3) 2014; 127 Gao, Yi, Zhu, Minikes, Monian, Thompson (CR32) 2019; 73 Hoxhaj, Manning (CR50) 2020; 20 Simonovitch, Schmukler, Bespalko, Iram, Frenkel, Holtzman (CR70) 2016; 51 Gupta, Laws, Villemagne, Ames, Bush, Ellis (CR51) 2011; 76 Morrow, Segall, Lund-Katz, Phillips, Knapp, Rupp (CR54) 2000; 39 Belaidi, Gunn, Wong, Ayton, Appukuttan, Roberts (CR73) 2018; 15 Argyri, Skamnaki, Stratikos, Chroni (CR72) 2011; 79 Mandal, Saharan, Tripathi, Murari (CR29) 2015; 78 Xu, Gupta, Martins, Martins, Fowler, Bush (CR56) 2015; 81 Chiang, Mao, Kang, Chang, Pandya, Vallabhajosula (CR30) 2017; 38 Gao, Monian, Pan, Zhang, Xiang, Jiang (CR48) 2016; 26 Sienski, Narayan, Bonner, Kory, Boland, Arczewska (CR59) 2021; 13 Ramassamy, Averill, Beffert, Bastianetto, Theroux, Lussier-Cacan (CR67) 1999; 27 Goodman (CR10) 1953; 118 Parcon, Balasubramaniam, Ayyadevara, Jones, Liu, Shmookler Reis (CR69) 2018; 14 Cruchaga, Kauwe, Nowotny, Bales, Pickering, Mayo (CR4) 2012; 21 Abdullah, Evans, Emmerich, Crynen, Shackleton, Keegan (CR46) 2017; 9 Southon, Szostak, Acevedo, Dent, Volitakis, Belaidi (CR43) 2020; 177 Ingold, Berndt, Schmitt, Doll, Poschmann, Buday (CR27) 2018; 172 Tomaszewski, He, Solomon, Lee, Mack, Quinn (CR45) 2020; 74 Friedmann Angeli, Schneider, Proneth, Tyurina, Tyurin, Hammond (CR26) 2014; 16 Riddell, Zhou, Atchison, Warwick, Atkinson, Jefferson (CR5) 2008; 28 Bulk, Geut, Wiarda, Ronen, Dijkstra (CR12) 2020; 215 Colombelli, Aoun, Tiranti (CR8) 2014; 38 Bradley, Markesbery, Lovell (CR36) 2010; 48 Quinn, Raman, Thomas, Yurko-Mauro, Nelson, Van Dyck (CR60) 2010; 304 Hubin, Verghese, van Nuland, Broersen (CR44) 2019; 593 Simon, Girod, Fonbonne, Salvador, Clement, Lanteri (CR52) 2012; 11 Lee, Cao, Mostoslavsky, Lombard, Liu, Bruns (CR74) 2008; 105 Bennett, Schneider, Buchman, Barnes, Boyle, Wilson (CR71) 2012; 9 Casadesus, Smith, Basu, Hua, Capobianco, Siedlak (CR41) 2007; 2 Dixon, Lemberg, Lamprecht, Skouta, Zaitsev, Gleason (CR22) 2012; 149 Shen, Wang, Tso, Jandacek, Woods, Liu (CR49) 2011; 105 Ayton, Faux, Bush, Alzheimer’s Disease Neuroimaging (CR2) 2015; 6 Baldeiras, Santana, Proenca, Garrucho, Pascoal, Rodrigues (CR40) 2010; 21 Ayton, Diouf, Bush (CR16) 2018; 89 Ramassamy, Averill, Beffert, Theroux, Lussier-Cacan, Cohn (CR66) 2000; 7 CR15 Ayton, Fazlollahi, Bourgeat, Raniga, Ng, Lim (CR18) 2017; 140 Montine, Kaye, Montine, McFarland, Morrow, Quinn (CR38) 2001; 125 Everett, Lermyte, Brooks, Tjendana-Tjhin, Plascencia-Villa, Hands-Portman (CR13) 2021; 7 Ayton, Faux, Bush (CR19) 2017; 74 Reed, Perluigi, Sultana, Pierce, Klein, Turner (CR39) 2008; 30 Nikseresht, Bush, Ayton (CR21) 2019; 176 Barberger-Gateau, Raffaitin, Letenneur, Berr, Tzourio, Dartigues (CR61) 2007; 69 Whalley, Deary, Starr, Wahle, Rance, Bourne (CR64) 2008; 87 Chouinard-Watkins, Rioux-Perreault, Fortier, Tremblay-Mercier, Zhang, Lawrence (CR47) 2013; 110 Diouf, Fazlollahi, Bush, Ayton (CR17) 2019; 124 Morrow, Hatters, Lu, Hochtl, Oberg, Rupp (CR55) 2002; 277 Williams, Lynn, Markesbery, Lovell (CR37) 2006; 27 Beydoun, Kaufman, Satia, Rosamond, Folsom (CR63) 2007; 85 Dixon, Patel, Welsch, Skouta, Lee, Hayano (CR33) 2014; 3 Brugarolas, Lei, Hurley, Manning, Reiling, Hafen (CR35) 2004; 18 Ansari, Scheff (CR31) 2010; 69 Hallgren, Sourander (CR11) 1960; 5 Mancias, Wang, Gygi, Harper, Kimmelman (CR34) 2014; 509 Ayton, Janelidze, Roberts, Palmqvist, Kalinowski, Diouf (CR20) 2021; 198 Kagerer, van Bergen, Li, Quevenco, Gietl, Studer (CR7) 2020; 12 Blennow, Hesse, Fredman (CR53) 1994; 5 Yan, Zou, Tuo, Xu, Li, Belaidi (CR23) 2021; 6 CR28 Zhou, Liu, Kang, Klionsky, Kroemer, Tang (CR68) 2020; 66 CR25 Damulina, Pirpamer, Soellradl, Sackl, Tinauer, Hofer (CR42) 2020; 296 Belaidi, Bush (CR9) 2016; 139 Ayton, Wang, Diouf, Schneider, Brockman, Morris (CR14) 2020; 25 Huang, Zandi, Tucker, Fitzpatrick, Kuller, Fried (CR62) 2005; 65 Mahoney-Sanchez, Belaidi, Bush, Ayton (CR1) 2016; 60 Perez, Magtanong, Dixon, Watts (CR24) 2020; 54 Namba, Tomonaga, Kawasaki, Otomo, Ikeda (CR57) 1991; 541 van Bergen, Li, Hua, Schreiner, Steininger, Quevenco (CR6) 2016; 6 L Abdullah (1568_CR46) 2017; 9 IH Lee (1568_CR74) 2008; 105 S Simonovitch (1568_CR70) 2016; 51 AA Belaidi (1568_CR73) 2018; 15 S Ayton (1568_CR14) 2020; 25 C Samieri (1568_CR65) 2011; 32 B Hallgren (1568_CR11) 1960; 5 I Ingold (1568_CR27) 2018; 172 VE Kagan (1568_CR58) 2017; 13 JD Mancias (1568_CR34) 2014; 509 DR Riddell (1568_CR5) 2008; 28 TJ Montine (1568_CR38) 2001; 125 R Simon (1568_CR52) 2012; 11 E Hubin (1568_CR44) 2019; 593 LJ Whalley (1568_CR64) 2008; 87 1568_CR25 R Chouinard-Watkins (1568_CR47) 2013; 110 H Xu (1568_CR56) 2015; 81 C Colombelli (1568_CR8) 2014; 38 1568_CR28 MA Beydoun (1568_CR63) 2007; 85 G Hoxhaj (1568_CR50) 2020; 20 JB Toledo (1568_CR3) 2014; 127 I Diouf (1568_CR17) 2019; 124 PA Parcon (1568_CR69) 2018; 14 SJ Dixon (1568_CR33) 2014; 3 L Argyri (1568_CR72) 2011; 79 S Ayton (1568_CR19) 2017; 74 MA Bradley (1568_CR36) 2010; 48 T Reed (1568_CR39) 2008; 30 L Goodman (1568_CR10) 1953; 118 G Casadesus (1568_CR41) 2007; 2 MA Ansari (1568_CR31) 2010; 69 C Ramassamy (1568_CR66) 2000; 7 WM Bulk (1568_CR12) 2020; 215 1568_CR15 S Nikseresht (1568_CR21) 2019; 176 SJ Dixon (1568_CR22) 2012; 149 VB Gupta (1568_CR51) 2011; 76 PK Mandal (1568_CR29) 2015; 78 TI Williams (1568_CR37) 2006; 27 SM Kagerer (1568_CR7) 2020; 12 A Damulina (1568_CR42) 2020; 296 TL Huang (1568_CR62) 2005; 65 L Shen (1568_CR49) 2011; 105 JA Morrow (1568_CR55) 2002; 277 M Gao (1568_CR48) 2016; 26 JP Friedmann Angeli (1568_CR26) 2014; 16 L Mahoney-Sanchez (1568_CR1) 2016; 60 B Zhou (1568_CR68) 2020; 66 Y Namba (1568_CR57) 1991; 541 P Barberger-Gateau (1568_CR61) 2007; 69 S Ayton (1568_CR2) 2015; 6 K Blennow (1568_CR53) 1994; 5 GC Chiang (1568_CR30) 2017; 38 S Ayton (1568_CR18) 2017; 140 HF Yan (1568_CR23) 2021; 6 M Gao (1568_CR32) 2019; 73 DA Bennett (1568_CR71) 2012; 9 S Ayton (1568_CR16) 2018; 89 C Ramassamy (1568_CR67) 1999; 27 JF Quinn (1568_CR60) 2010; 304 J Everett (1568_CR13) 2021; 7 JM van Bergen (1568_CR6) 2016; 6 N Tomaszewski (1568_CR45) 2020; 74 S Ayton (1568_CR20) 2021; 198 AA Belaidi (1568_CR9) 2016; 139 I Baldeiras (1568_CR40) 2010; 21 A Southon (1568_CR43) 2020; 177 J Brugarolas (1568_CR35) 2004; 18 G Sienski (1568_CR59) 2021; 13 MA Perez (1568_CR24) 2020; 54 JA Morrow (1568_CR54) 2000; 39 C Cruchaga (1568_CR4) 2012; 21 |
| References_xml | – volume: 149 start-page: 1060 year: 2012 end-page: 72 ident: CR22 article-title: Ferroptosis: an iron-dependent form of nonapoptotic cell death publication-title: Cell doi: 10.1016/j.cell.2012.03.042 – volume: 105 start-page: 124 year: 2011 end-page: 8 ident: CR49 article-title: Apolipoprotein E reduces food intake via PI3K/Akt signaling pathway in the hypothalamus publication-title: Physiol Behav doi: 10.1016/j.physbeh.2011.04.018 – volume: 105 start-page: 3374 year: 2008 end-page: 9 ident: CR74 article-title: A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0712145105 – volume: 87 start-page: 449 year: 2008 end-page: 54 ident: CR64 article-title: n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: An observational follow-up study in late adulthood publication-title: Am J Clin Nutr doi: 10.1093/ajcn/87.2.449 – volume: 48 start-page: 1570 year: 2010 end-page: 6 ident: CR36 article-title: Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2010.02.016 – volume: 509 start-page: 105 year: 2014 end-page: 9 ident: CR34 article-title: Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy publication-title: Nature doi: 10.1038/nature13148 – volume: 18 start-page: 2893 year: 2004 end-page: 904 ident: CR35 article-title: Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex publication-title: Genes Dev doi: 10.1101/gad.1256804 – volume: 215 start-page: 116808 year: 2020 ident: CR12 article-title: Quantitative MRI and laser ablation-inductively coupled plasma-mass spectrometry imaging of iron in the frontal cortex of healthy controls and Alzheimer’s disease patients publication-title: Neuroimage. doi: 10.1016/j.neuroimage.2020.116808 – volume: 13 start-page: 81 year: 2017 end-page: 90 ident: CR58 article-title: Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis publication-title: Nat Chem Biol doi: 10.1038/nchembio.2238 – volume: 14 start-page: 230 year: 2018 end-page: 42 ident: CR69 article-title: Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2017.07.754 – volume: 74 start-page: 975 year: 2020 end-page: 90 ident: CR45 article-title: Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer’s Disease Cooperative Study-Sponsored DHA Clinical Trial publication-title: J Alzheimer’s Dis: JAD doi: 10.3233/JAD-191017 – ident: CR25 – volume: 39 start-page: 11657 year: 2000 end-page: 66 ident: CR54 article-title: Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain publication-title: Biochemistry doi: 10.1021/bi000099m – volume: 124 start-page: 335 year: 2019 end-page: 9 ident: CR17 article-title: Alzheimer’s disease Neuroimaging I. Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying beta-amyloid pathology publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2018.12.010 – volume: 2 year: 2007 ident: CR41 article-title: Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease publication-title: Mol Neurodegeneration doi: 10.1186/1750-1326-2-2 – volume: 304 start-page: 1903 year: 2010 end-page: 11 ident: CR60 article-title: Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: A randomized trial publication-title: JAMA doi: 10.1001/jama.2010.1510 – volume: 65 start-page: 1409 year: 2005 end-page: 14 ident: CR62 article-title: Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4 publication-title: Neurology doi: 10.1212/01.wnl.0000183148.34197.2e – volume: 26 start-page: 1021 year: 2016 end-page: 32 ident: CR48 article-title: Ferroptosis is an autophagic cell death process publication-title: Cell Res doi: 10.1038/cr.2016.95 – volume: 76 start-page: 1091 year: 2011 end-page: 8 ident: CR51 article-title: Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging publication-title: Neurology doi: 10.1212/WNL.0b013e318211c352 – ident: CR15 – volume: 541 start-page: 163 year: 1991 end-page: 6 ident: CR57 article-title: Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer’s disease and kuru plaque amyloid in Creutzfeldt-Jakob disease publication-title: Brain Res doi: 10.1016/0006-8993(91)91092-F – volume: 11 start-page: 1389 year: 2012 end-page: 403 ident: CR52 article-title: Total ApoE and ApoE4 isoform assays in an Alzheimer’s disease case-control study by targeted mass spectrometry (n=669): a pilot assay for methionine-containing proteotypic peptides publication-title: Mol Cell Proteom doi: 10.1074/mcp.M112.018861 – volume: 89 start-page: 456 year: 2018 end-page: 60 ident: CR16 article-title: Alzheimer’s disease Neuroimaging I. Evidence that iron accelerates Alzheimer’s pathology: a CSF biomarker study publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp-2017-316551 – volume: 28 start-page: 11445 year: 2008 end-page: 53 ident: CR5 article-title: Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1972-08.2008 – volume: 38 start-page: 123 year: 2014 end-page: 36 ident: CR8 article-title: Defective lipid metabolism in neurodegeneration with brain iron accumulation (NBIA) syndromes: Not only a matter of iron. J Inherited Metab publication-title: Dis. – volume: 9 start-page: 964 year: 2017 end-page: 85 ident: CR46 article-title: APOE epsilon4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer’s Disease publication-title: Aging (Albany NY) doi: 10.18632/aging.101203 – volume: 5 start-page: 2534 year: 1994 end-page: 6 ident: CR53 article-title: Cerebrospinal fluid apolipoprotein E is reduced in Alzheimer’s disease publication-title: Neuroreport doi: 10.1097/00001756-199412000-00032 – volume: 32 start-page: 2317 e13 year: 2011 end-page: 22 ident: CR65 article-title: omega-3 fatty acids and cognitive decline: Modulation by ApoEepsilon4 allele and depression publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2010.03.020 – volume: 7 start-page: 23 year: 2000 end-page: 37 ident: CR66 article-title: Oxidative insults are associated with apolipoprotein E genotype in Alzheimer’s disease brain publication-title: Neurobiol Dis doi: 10.1006/nbdi.1999.0273 – volume: 51 start-page: 915 year: 2016 end-page: 27 ident: CR70 article-title: Impaired Autophagy in APOE4 Astrocytes publication-title: J Alzheimer’s Dis: JAD doi: 10.3233/JAD-151101 – volume: 198 start-page: 101904 year: 2021 ident: CR20 article-title: Acute phase markers in CSF reveal inflammatory changes in Alzheimer’s disease that intersect with pathology, APOE epsilon4, sex and age publication-title: Prog Neurobiol doi: 10.1016/j.pneurobio.2020.101904 – volume: 7 start-page: eabf6707 year: 2021 ident: CR13 article-title: Biogenic metallic elements in the human brain? publication-title: Sci Adv. doi: 10.1126/sciadv.abf6707 – volume: 27 start-page: 544 year: 1999 end-page: 53 ident: CR67 article-title: Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer’s disease is related to the apolipoprotein E genotype publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(99)00102-1 – volume: 118 start-page: 97 year: 1953 end-page: 130 ident: CR10 article-title: Alzheimer’s disease; A clinico-pathologic analysis of twenty-three cases with a theory on pathogenesis publication-title: J Nerv Ment Dis doi: 10.1097/00005053-195308000-00001 – volume: 16 start-page: 1180 year: 2014 end-page: 91 ident: CR26 article-title: Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice publication-title: Nat cell Biol doi: 10.1038/ncb3064 – volume: 27 start-page: 1094 year: 2006 end-page: 9 ident: CR37 article-title: Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer’s disease publication-title: Neurobiol aging doi: 10.1016/j.neurobiolaging.2005.06.004 – volume: 6 year: 2016 ident: CR6 article-title: Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment publication-title: Sci Rep doi: 10.1038/srep35514 – volume: 78 start-page: 702 year: 2015 end-page: 10 ident: CR29 article-title: Brain glutathione levels-a novel biomarker for mild cognitive impairment and Alzheimer’s disease publication-title: Biol psychiatry doi: 10.1016/j.biopsych.2015.04.005 – volume: 6 start-page: 49 year: 2021 ident: CR23 article-title: Ferroptosis: mechanisms and links with diseases publication-title: Signal Transduct Target Ther doi: 10.1038/s41392-020-00428-9 – volume: 12 start-page: e12002 year: 2020 ident: CR7 article-title: APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old-aged adults publication-title: Alzheimers Dement (Amst) – volume: 69 start-page: 155 year: 2010 end-page: 67 ident: CR31 article-title: Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex publication-title: J Neuropathol Exp Neurol doi: 10.1097/NEN.0b013e3181cb5af4 – volume: 172 start-page: 409 year: 2018 end-page: 22 e21 ident: CR27 article-title: Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis publication-title: Cell doi: 10.1016/j.cell.2017.11.048 – volume: 38 start-page: 1130 year: 2017 end-page: 7 ident: CR30 article-title: Relationships among cortical glutathione levels, brain amyloidosis, and memory in healthy older adults investigated in vivo with (1)H-MRS and Pittsburgh Compound-B PET publication-title: AJNR Am J Neuroradiol doi: 10.3174/ajnr.A5143 – volume: 593 start-page: 1144 year: 2019 end-page: 53 ident: CR44 article-title: Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation publication-title: FEBS Lett doi: 10.1002/1873-3468.13428 – volume: 66 start-page: 89 year: 2020 end-page: 100 ident: CR68 article-title: Ferroptosis is a type of autophagy-dependent cell death publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2019.03.002 – volume: 60 start-page: 325 year: 2016 end-page: 35 ident: CR1 article-title: The complex role of apolipoprotein E in Alzheimer’s disease: An overview and update publication-title: J Mol Neurosci doi: 10.1007/s12031-016-0839-z – volume: 140 start-page: 2112 year: 2017 end-page: 9 ident: CR18 article-title: Cerebral quantitative susceptibility mapping predicts amyloid-beta-related cognitive decline publication-title: Brain: J Neurol doi: 10.1093/brain/awx137 – volume: 15 start-page: 1055 year: 2018 end-page: 62 ident: CR73 article-title: Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice publication-title: Neurotherapeutics doi: 10.1007/s13311-018-0656-x – volume: 177 start-page: 656 year: 2020 end-page: 67 ident: CR43 article-title: Cu(II) (atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease publication-title: Br J Pharm doi: 10.1111/bph.14881 – volume: 73 start-page: 354 year: 2019 end-page: 63 e3 ident: CR32 article-title: Role of Mitochondria in Ferroptosis publication-title: Mol Cell doi: 10.1016/j.molcel.2018.10.042 – volume: 277 start-page: 50380 year: 2002 end-page: 5 ident: CR55 article-title: Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease publication-title: J Biol Chem doi: 10.1074/jbc.M204898200 – volume: 81 start-page: 38 year: 2015 end-page: 48 ident: CR56 article-title: Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2015.06.016 – volume: 20 start-page: 74 year: 2020 end-page: 88 ident: CR50 article-title: The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism publication-title: Nat Rev Cancer doi: 10.1038/s41568-019-0216-7 – volume: 6 year: 2015 ident: CR2 article-title: Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE publication-title: Nat Commun doi: 10.1038/ncomms7760 – volume: 13 start-page: eaaz4564 year: 2021 ident: CR59 article-title: APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aaz4564 – volume: 9 start-page: 646 year: 2012 end-page: 63 ident: CR71 article-title: Overview and findings from the rush Memory and Aging Project publication-title: Curr Alzheimer Res doi: 10.2174/156720512801322663 – volume: 3 start-page: e02523 year: 2014 ident: CR33 article-title: Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis publication-title: Elife doi: 10.7554/eLife.02523 – volume: 5 start-page: 307 year: 1960 end-page: 10 ident: CR11 article-title: The non-haemin iron in the cerebral cortex in Alzheimer’s disease publication-title: J Neurochem doi: 10.1111/j.1471-4159.1960.tb13369.x – volume: 21 start-page: 1165 year: 2010 end-page: 77 ident: CR40 article-title: Oxidative damage and progression to Alzheimer’s disease in patients with mild cognitive impairment publication-title: J Alzheimer’s Dis: JAD doi: 10.3233/JAD-2010-091723 – volume: 79 start-page: 251 year: 2011 end-page: 7 ident: CR72 article-title: A simple approach for human recombinant apolipoprotein E4 expression and purification publication-title: Protein Expr Purif doi: 10.1016/j.pep.2011.06.011 – volume: 85 start-page: 1103 year: 2007 end-page: 11 ident: CR63 article-title: Plasma n-3 fatty acids and the risk of cognitive decline in older adults: The Atherosclerosis risk in communities study publication-title: Am J Clin Nutr doi: 10.1093/ajcn/85.4.1103 – volume: 139 start-page: 179 year: 2016 end-page: 97 ident: CR9 article-title: Iron neurochemistry in Alzheimer’s disease and Parkinson’s disease: Targets for therapeutics publication-title: J. Neurochem. doi: 10.1111/jnc.13425 – volume: 30 start-page: 107 year: 2008 end-page: 20 ident: CR39 article-title: Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer’s disease publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2007.12.007 – volume: 125 start-page: 510 year: 2001 end-page: 2 ident: CR38 article-title: Cerebrospinal fluid abeta42, tau, and f2-isoprostane concentrations in patients with Alzheimer disease, other dementias, and in age-matched controls publication-title: Arch Pathol Lab Med doi: 10.5858/2001-125-0510-CFATAF – volume: 110 start-page: 1751 year: 2013 end-page: 9 ident: CR47 article-title: Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE epsilon4 allele publication-title: Br J Nutr doi: 10.1017/S0007114513001268 – volume: 54 start-page: 447 year: 2020 end-page: 54 e4 ident: CR24 article-title: Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells publication-title: Dev Cell doi: 10.1016/j.devcel.2020.06.019 – volume: 127 start-page: 621 year: 2014 end-page: 32 ident: CR3 article-title: CSF Apo-E levels associate with cognitive decline and MRI changes publication-title: Acta Neuropathol doi: 10.1007/s00401-013-1236-0 – volume: 176 start-page: 3622 year: 2019 end-page: 35 ident: CR21 article-title: Treating Alzheimer’s disease by targeting iron publication-title: Br J Pharm doi: 10.1111/bph.14567 – volume: 21 start-page: 4558 year: 2012 end-page: 71 ident: CR4 article-title: Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer’s disease publication-title: Hum Mol Genet doi: 10.1093/hmg/dds296 – volume: 25 start-page: 2932 year: 2020 end-page: 41 ident: CR14 article-title: Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology publication-title: Mol Psychiatry doi: 10.1038/s41380-019-0375-7 – ident: CR28 – volume: 74 start-page: 122 year: 2017 end-page: 5 ident: CR19 article-title: Association of cerebrospinal fluid ferritin level with preclinical cognitive decline in APOE-epsilon4 Carriers publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2016.4406 – volume: 69 start-page: 1921 year: 2007 end-page: 30 ident: CR61 article-title: Dietary patterns and risk of dementia: the Three-City cohort study publication-title: Neurology doi: 10.1212/01.wnl.0000278116.37320.52 – volume: 296 start-page: 619 year: 2020 end-page: 26 ident: CR42 article-title: Cross-sectional and longitudinal assessment of brain iron level in Alzheimer disease using 3-T MRI publication-title: Radiology doi: 10.1148/radiol.2020192541 – volume: 110 start-page: 1751 year: 2013 ident: 1568_CR47 publication-title: Br J Nutr doi: 10.1017/S0007114513001268 – volume: 14 start-page: 230 year: 2018 ident: 1568_CR69 publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2017.07.754 – volume: 16 start-page: 1180 year: 2014 ident: 1568_CR26 publication-title: Nat cell Biol doi: 10.1038/ncb3064 – volume: 127 start-page: 621 year: 2014 ident: 1568_CR3 publication-title: Acta Neuropathol doi: 10.1007/s00401-013-1236-0 – volume: 25 start-page: 2932 year: 2020 ident: 1568_CR14 publication-title: Mol Psychiatry doi: 10.1038/s41380-019-0375-7 – volume: 60 start-page: 325 year: 2016 ident: 1568_CR1 publication-title: J Mol Neurosci doi: 10.1007/s12031-016-0839-z – volume: 73 start-page: 354 year: 2019 ident: 1568_CR32 publication-title: Mol Cell doi: 10.1016/j.molcel.2018.10.042 – volume: 30 start-page: 107 year: 2008 ident: 1568_CR39 publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2007.12.007 – volume: 15 start-page: 1055 year: 2018 ident: 1568_CR73 publication-title: Neurotherapeutics doi: 10.1007/s13311-018-0656-x – volume: 118 start-page: 97 year: 1953 ident: 1568_CR10 publication-title: J Nerv Ment Dis doi: 10.1097/00005053-195308000-00001 – volume: 125 start-page: 510 year: 2001 ident: 1568_CR38 publication-title: Arch Pathol Lab Med doi: 10.5858/2001-125-0510-CFATAF – volume: 124 start-page: 335 year: 2019 ident: 1568_CR17 publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2018.12.010 – volume: 26 start-page: 1021 year: 2016 ident: 1568_CR48 publication-title: Cell Res doi: 10.1038/cr.2016.95 – volume: 105 start-page: 124 year: 2011 ident: 1568_CR49 publication-title: Physiol Behav doi: 10.1016/j.physbeh.2011.04.018 – volume: 87 start-page: 449 year: 2008 ident: 1568_CR64 publication-title: Am J Clin Nutr doi: 10.1093/ajcn/87.2.449 – volume: 27 start-page: 544 year: 1999 ident: 1568_CR67 publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(99)00102-1 – volume: 177 start-page: 656 year: 2020 ident: 1568_CR43 publication-title: Br J Pharm doi: 10.1111/bph.14881 – volume: 215 start-page: 116808 year: 2020 ident: 1568_CR12 publication-title: Neuroimage. doi: 10.1016/j.neuroimage.2020.116808 – volume: 172 start-page: 409 year: 2018 ident: 1568_CR27 publication-title: Cell doi: 10.1016/j.cell.2017.11.048 – volume: 593 start-page: 1144 year: 2019 ident: 1568_CR44 publication-title: FEBS Lett doi: 10.1002/1873-3468.13428 – volume: 74 start-page: 122 year: 2017 ident: 1568_CR19 publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2016.4406 – volume: 6 year: 2016 ident: 1568_CR6 publication-title: Sci Rep doi: 10.1038/srep35514 – volume: 5 start-page: 2534 year: 1994 ident: 1568_CR53 publication-title: Neuroreport doi: 10.1097/00001756-199412000-00032 – volume: 18 start-page: 2893 year: 2004 ident: 1568_CR35 publication-title: Genes Dev doi: 10.1101/gad.1256804 – volume: 39 start-page: 11657 year: 2000 ident: 1568_CR54 publication-title: Biochemistry doi: 10.1021/bi000099m – volume: 13 start-page: eaaz4564 year: 2021 ident: 1568_CR59 publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aaz4564 – volume: 7 start-page: 23 year: 2000 ident: 1568_CR66 publication-title: Neurobiol Dis doi: 10.1006/nbdi.1999.0273 – volume: 54 start-page: 447 year: 2020 ident: 1568_CR24 publication-title: Dev Cell doi: 10.1016/j.devcel.2020.06.019 – volume: 76 start-page: 1091 year: 2011 ident: 1568_CR51 publication-title: Neurology doi: 10.1212/WNL.0b013e318211c352 – volume: 38 start-page: 1130 year: 2017 ident: 1568_CR30 publication-title: AJNR Am J Neuroradiol doi: 10.3174/ajnr.A5143 – volume: 27 start-page: 1094 year: 2006 ident: 1568_CR37 publication-title: Neurobiol aging doi: 10.1016/j.neurobiolaging.2005.06.004 – volume: 11 start-page: 1389 year: 2012 ident: 1568_CR52 publication-title: Mol Cell Proteom doi: 10.1074/mcp.M112.018861 – volume: 66 start-page: 89 year: 2020 ident: 1568_CR68 publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2019.03.002 – volume: 140 start-page: 2112 year: 2017 ident: 1568_CR18 publication-title: Brain: J Neurol doi: 10.1093/brain/awx137 – volume: 7 start-page: eabf6707 year: 2021 ident: 1568_CR13 publication-title: Sci Adv. doi: 10.1126/sciadv.abf6707 – volume: 3 start-page: e02523 year: 2014 ident: 1568_CR33 publication-title: Elife doi: 10.7554/eLife.02523 – ident: 1568_CR25 doi: 10.1016/j.chembiol.2018.11.016 – ident: 1568_CR15 doi: 10.1002/alz.12282 – volume: 2 year: 2007 ident: 1568_CR41 publication-title: Mol Neurodegeneration doi: 10.1186/1750-1326-2-2 – volume: 28 start-page: 11445 year: 2008 ident: 1568_CR5 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1972-08.2008 – volume: 21 start-page: 1165 year: 2010 ident: 1568_CR40 publication-title: J Alzheimer’s Dis: JAD doi: 10.3233/JAD-2010-091723 – volume: 13 start-page: 81 year: 2017 ident: 1568_CR58 publication-title: Nat Chem Biol doi: 10.1038/nchembio.2238 – volume: 69 start-page: 1921 year: 2007 ident: 1568_CR61 publication-title: Neurology doi: 10.1212/01.wnl.0000278116.37320.52 – volume: 81 start-page: 38 year: 2015 ident: 1568_CR56 publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2015.06.016 – volume: 149 start-page: 1060 year: 2012 ident: 1568_CR22 publication-title: Cell doi: 10.1016/j.cell.2012.03.042 – volume: 20 start-page: 74 year: 2020 ident: 1568_CR50 publication-title: Nat Rev Cancer doi: 10.1038/s41568-019-0216-7 – volume: 9 start-page: 646 year: 2012 ident: 1568_CR71 publication-title: Curr Alzheimer Res doi: 10.2174/156720512801322663 – volume: 89 start-page: 456 year: 2018 ident: 1568_CR16 publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp-2017-316551 – volume: 9 start-page: 964 year: 2017 ident: 1568_CR46 publication-title: Aging (Albany NY) doi: 10.18632/aging.101203 – volume: 176 start-page: 3622 year: 2019 ident: 1568_CR21 publication-title: Br J Pharm doi: 10.1111/bph.14567 – volume: 79 start-page: 251 year: 2011 ident: 1568_CR72 publication-title: Protein Expr Purif doi: 10.1016/j.pep.2011.06.011 – volume: 48 start-page: 1570 year: 2010 ident: 1568_CR36 publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2010.02.016 – volume: 85 start-page: 1103 year: 2007 ident: 1568_CR63 publication-title: Am J Clin Nutr doi: 10.1093/ajcn/85.4.1103 – volume: 198 start-page: 101904 year: 2021 ident: 1568_CR20 publication-title: Prog Neurobiol doi: 10.1016/j.pneurobio.2020.101904 – volume: 6 start-page: 49 year: 2021 ident: 1568_CR23 publication-title: Signal Transduct Target Ther doi: 10.1038/s41392-020-00428-9 – volume: 277 start-page: 50380 year: 2002 ident: 1568_CR55 publication-title: J Biol Chem doi: 10.1074/jbc.M204898200 – volume: 65 start-page: 1409 year: 2005 ident: 1568_CR62 publication-title: Neurology doi: 10.1212/01.wnl.0000183148.34197.2e – volume: 51 start-page: 915 year: 2016 ident: 1568_CR70 publication-title: J Alzheimer’s Dis: JAD doi: 10.3233/JAD-151101 – volume: 105 start-page: 3374 year: 2008 ident: 1568_CR74 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0712145105 – volume: 541 start-page: 163 year: 1991 ident: 1568_CR57 publication-title: Brain Res doi: 10.1016/0006-8993(91)91092-F – volume: 21 start-page: 4558 year: 2012 ident: 1568_CR4 publication-title: Hum Mol Genet doi: 10.1093/hmg/dds296 – volume: 32 start-page: 2317 e13 year: 2011 ident: 1568_CR65 publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2010.03.020 – volume: 6 year: 2015 ident: 1568_CR2 publication-title: Nat Commun doi: 10.1038/ncomms7760 – volume: 139 start-page: 179 year: 2016 ident: 1568_CR9 publication-title: J. Neurochem. doi: 10.1111/jnc.13425 – volume: 5 start-page: 307 year: 1960 ident: 1568_CR11 publication-title: J Neurochem doi: 10.1111/j.1471-4159.1960.tb13369.x – volume: 78 start-page: 702 year: 2015 ident: 1568_CR29 publication-title: Biol psychiatry doi: 10.1016/j.biopsych.2015.04.005 – volume: 12 start-page: e12002 year: 2020 ident: 1568_CR7 publication-title: Alzheimers Dement (Amst) – volume: 69 start-page: 155 year: 2010 ident: 1568_CR31 publication-title: J Neuropathol Exp Neurol doi: 10.1097/NEN.0b013e3181cb5af4 – volume: 296 start-page: 619 year: 2020 ident: 1568_CR42 publication-title: Radiology doi: 10.1148/radiol.2020192541 – volume: 509 start-page: 105 year: 2014 ident: 1568_CR34 publication-title: Nature doi: 10.1038/nature13148 – ident: 1568_CR28 doi: 10.1007/s13311-021-01111-9 – volume: 304 start-page: 1903 year: 2010 ident: 1568_CR60 publication-title: JAMA doi: 10.1001/jama.2010.1510 – volume: 38 start-page: 123 year: 2014 ident: 1568_CR8 publication-title: Dis. – volume: 74 start-page: 975 year: 2020 ident: 1568_CR45 publication-title: J Alzheimer’s Dis: JAD doi: 10.3233/JAD-191017 |
| SSID | ssj0014765 |
| Score | 2.645552 |
| Snippet | Allelic variation to the
APOE
gene confers the greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance of... Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer's disease (AD). Independent of genotype, low abundance of... Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance of... |
| SourceID | pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 211 |
| SubjectTerms | 1-Phosphatidylinositol 3-kinase 13/1 13/106 13/109 13/51 14/63 631/378 692/699 82/80 82/83 96/31 Aged Aged, 80 and over AKT protein Alleles Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Animals Apolipoprotein E Apolipoprotein E4 - genetics Apolipoprotein E4 - metabolism Apolipoproteins Apolipoproteins E - genetics Apolipoproteins E - metabolism Autophagy Autopsy Behavioral Sciences Biological Psychology Brain - metabolism Cell death Cerebrospinal fluid Cognitive ability Female Ferritin Ferritins - metabolism Ferroptosis Ferroptosis - drug effects Ferroptosis - physiology Genotype Genotypes Health risk assessment Humans Iron Iron - metabolism Isoforms Lipid peroxidation Lipid Peroxidation - drug effects Male Medicine Medicine & Public Health Neurodegenerative diseases Neuroimaging Neurons - metabolism Neurosciences Pharmacotherapy Polyunsaturated fatty acids Psychiatry Temporal lobe |
| SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da90gFJetY7CXsu-l7UYGe9ukiZqrPo1SWrrB9rTCfRM1uhsoJrtJKfe_79HkptyV9iWEqETPOXp-eo7nIPTFe-EIryUunS0wA4yMBS08tqYiznAQshSO4dfvxcUl-7msltOBWz-5VW7XxLRQ162NZ-THIJcy2gxE8b37h2PWqGhdnVJoPEXPYuiy6NLFl_OGq2Q8pZIsaRWtnYJNl2YKKo57WLxFgaMve7xMLPDNrmK6hzbvO03-ZzlNCun8JdqfkGR-MrL-FXriwmv0fMwtuXmDfpzE_AtdmwIxNCE_yzt4CcPVJm_CqjHN0OferddtN7R90-dmkxtQbPHkPH1vhia03Ur_3bxFl-dnf04v8JQ3AVvG2YAZqF3DmSmtY9rTuqzpgtfeFdxWYqFBpWvqjJWel7aqSF1I662tTGFqJ61x9B3aC21wH1BOAUC42jjYNEkmNdfCaE1qeAriuS8yVG6JpuwUVDzmtrhSybhNhRoJrYDQKhFa3WTo69ymG0NqPFr7aMsLNU2vXt0JQ4Y-z8UwMaK1QwfXXveKALYCuMgJydD7kXXz7yjs04BK0JrvMHWuEINu75aEZpWCb0tecSlZhr5t2X_XrYdHcfD4KA7RCwJgafQGP0J7w_rafQSwM5hPSaJvAW-U_ZE priority: 102 providerName: ProQuest |
| Title | Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy |
| URI | https://link.springer.com/article/10.1038/s41380-022-01568-w https://www.ncbi.nlm.nih.gov/pubmed/35484240 https://www.proquest.com/docview/3059116780 https://www.proquest.com/docview/2658232722 https://pubmed.ncbi.nlm.nih.gov/PMC9757994 |
| Volume | 29 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3da9swED_6wcZeytZ9peuCB3vbzGxJjqTHJCR0g4YxVsibsWRpMRTbxC4l__1OsuORdRvsxTaWZMunj_vJd_odwHtrhSE8l2FsdBQyxMihoJENtUqIURw7madjuF5Nrm7Yl3WyPgKy3wvjnfY9paWfpvfeYZ8anGxFFDrfc7f5V4T3x3DqqNtdr55P5oPlgHEfPjKmibNwCtZvlImo-MMzDpXRA4T50FHyN2upV0LLp3DWo8dg2tX3GRyZ8hwedfEkd-fw-Lq3lD-Hz1MXfqGuPA9DUQaLoMaLsr3dBUW5KVTRNoE1221Vt1VTNIHaBQr1mvtx7u8XbVFW9Sb7sXsBN8vF9_lV2IdNCDXjrA0Zal3FmYq1YZmleZzTCc-tibhOxCRDjZ5Ro7S0PNZJQvJIaqt1oiKVG6mVoS_hpKxK8xoCivjB5MrgmkkymfFMqCwjOR4FsdxGI4j38kt1zynuQlvcpt62TUXayTxFmade5un9CD4MZeqOUeOfuS_3zZL2o6tJcY6Szn4ksALvhmQcF87YkZWmumtSgtAK0SInZASvulYcXkdxmYZSwtL8oH2HDI5z-zClLDaee1vyhEvJRvBx3xN-VevvX3Hxf9nfwBOC2KlzDr-Ek3Z7Z94i9mnVGI75mo_hdLqczVZ4ni1WX7-N_RD4CV-5Axg |
| linkProvider | Springer Nature |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VrRC9IN4ECgQJThA1sZ21fUCowFa7tF0h1Eq9hdhx2EhVkm5SrfKn-I2M89hqqeitlyiK7SSeGXu-8dgzAO_SVBjCE-kFRvseQ4zsCeqnnlYhMYqjkLXhGI7n4-kp-34Wnm3Bn-EsjN1WOcyJ7USdFNquke-hXErrMxD-5_LCs1mjrHd1SKHRicWhaVZoslWfZt-Qv-8JOZicfJ16fVYBTzPOao-hUlKcqUAbFqc0CRI65klqfK5DMY5R4cXUKC1THugwJIkvdap1qHyVGKmVofjeO7DNKJoyI9j-Mpn_-Ln2WzDeJq8MaGj9q4L1x3R8KvYqVBfC9-zueXt8WXirTVV4Dd9e36b5j6-2VYEHD-B-j13d_U7YHsKWyR_B3S6bZfMYZvs240NZtKEfstyduCXe5PV542b5IlNZXbmpWS6Lsi6qrHJV4ypUpXatvn2e1VlelIv4d_METm-Fpk9hlBe5eQ4uRchiEmXQTJNMxjwWKo5JgldBUp76DgQD0SLdhzG32TTOo9adTkXUETpCQkctoaOVAx_WbcouiMeNtXcHXkT9gK6iK_Fz4O26GIei9a_EuSkuq4ggmkOAyglx4FnHuvXnKFqGSCVszTeYuq5gw3xvluTZog33LXnIpWQOfBzYf_Vb_-_Fi5t78QbuTU-Oj6Kj2fzwJewQhGrdXvRdGNXLS_MKoVatXvfy7cKv2x5SfwG-VT4x |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbtQw0CpFIC6IZwkUCBKcwNrEdtb2AaGKdtWlUHGg0t5C7NhspCoJm1Sr_Bpfx9hJtloqeuslimI7iefhmfGMZxB6a60whOcSx0ZHmIGOjAWNLNYqIUZxIDKfjuHb6fT4jH1ZJIsd9Gc8C-PCKsc10S_UeaXdHvkE6FI6n4GIJnYIi_h-OPtU_8augpTztI7lNHoSOTHdGsy35uP8EHD9jpDZ0Y_Px3ioMIA146zFDASU4kzF2rDM0jzO6ZTn1kRcJ2KagfDLqFFaWh7rJCF5JLXVOlGRyo3UylB47y10m9MkdjzGFxtjL2bcl7GMaeI8rYINB3YiKiYNCA4RYRdH7w4yC7zeFopXNN2rAZv_eG29MJw9QPcHLTY86MnuIdox5SN0p69r2T1G8wNX-6GufBKIogyPwhpuyva8C4tyWaiibUJrVquqbqumaELVhQqEqtu198-Ltiirepn96p6gsxuB6FO0W1aleYZCCsqLyZUBg00ymfFMqCwjOVwFsdxGAYpHoKV6SGju6mqcp96xTkXaAzoFQKce0Ok6QO83Y-o-nce1vfdHXKQDazfpJSEG6M2mGZjSeVqy0lQXTUpArwNVlRMSoL0edZvPUbARAUowmm8hddPBJfzebimLpU_8LXnCpWQB-jCi__K3_j-L59fP4jW6C4yUfp2fnrxA9wjobH1Q-j7abVcX5iXoXK165Yk7RD9vmpv-AvCDQQE |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Apolipoprotein+E+potently+inhibits+ferroptosis+by+blocking+ferritinophagy&rft.jtitle=Molecular+psychiatry&rft.au=Belaidi%2C+Abdel+Ali&rft.au=Masaldan%2C+Shashank&rft.au=Southon%2C+Adam&rft.au=Kalinowski%2C+Pawel&rft.date=2024-02-01&rft.issn=1359-4184&rft.eissn=1476-5578&rft.volume=29&rft.issue=2&rft.spage=211&rft.epage=220&rft_id=info:doi/10.1038%2Fs41380-022-01568-w&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41380_022_01568_w |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1359-4184&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1359-4184&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1359-4184&client=summon |