Canonical WNT Signaling Pathway is Altered in Mesenchymal Stromal Cells From Acute Myeloid Leukemia Patients And Is Implicated in BMP4 Down-Regulation

• Published in: Translational oncology Vol. 12; no. 4; pp. 614 - 625
• Main Authors: Azevedo, Pedro L., Oliveira, Nathalia C.A., Corrêa, Stephany, Castelo-Branco, Morgana T.L., Abdelhay, Eliana, Binato, Renata
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2019; Elsevier

Mesenchymal stromal cells (hMSCs) are key components of the bone marrow microenvironment (BMM). A molecular signature in hMSCs from Acute myeloid leukemia patients (hMSC-AML) has been proposed where BMP4 is decreased and could be regulated by WNT signaling pathway. Therefore, the aim of this work wa...