Hyaluronan suppresses enhanced cathepsin K expression via activation of NF-κB with mechanical stress loading in a human chondrocytic HCS-2/8 cells

• Published in: Scientific reports Vol. 10; no. 1; p. 216
• Main Authors: Suzuki, Mochihito, Takahashi, Nobunori, Sobue, Yasumori, Ohashi, Yoshifumi, Kishimoto, Kenji, Hattori, Kyosuke, Ishiguro, Naoki, Kojima, Toshihisa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.01.2020; Nature Publishing Group
• Subjects: 38/77; 692/4017; 692/4023/808; 82/1; Adjuvants, Immunologic - pharmacology; Arthritis; Bone remodeling; Bone resorption; Bone surgery; Cartilage; Cartilage (articular); Cartilage diseases; Cartilage, Articular - cytology; Cartilage, Articular - drug effects; Cartilage, Articular - metabolism; Cathepsin K; Cathepsin K - genetics; Cathepsin K - metabolism; Cells, Cultured; Chondrocytes; Chondrocytes - cytology; Chondrocytes - drug effects; Chondrocytes - metabolism; Collagen; Gene Expression Regulation - drug effects; Homeostasis; Humanities and Social Sciences; Humans; Hyaluronan Receptors - genetics; Hyaluronan Receptors - metabolism; Hyaluronic acid; Hyaluronic Acid - pharmacology; Loading; Molecular weight; multidisciplinary; NF-kappa B - genetics; NF-kappa B - metabolism; NF-κB protein; Osteoarthritis; Phosphorylation; Protein expression; Proteins; Science; Science (multidisciplinary); Signal Transduction; Stress, Mechanical; Supplements

Cathepsin K is a protease known to be involved in not only bone remodeling and resorption, but also articular cartilage degradation that leads to osteoarthritis (OA). Hyaluronan (HA) plays a pivotal role in maintaining homeostasis within articular chondrocytes. Intra-articular supplementation of hig...