R-loops at microRNA encoding loci promote co-transcriptional processing of pri-miRNAs in plants

• Published in: Nature plants Vol. 8; no. 4; pp. 402 - 418
• Main Authors: Gonzalo, Lucia, Tossolini, Ileana, Gulanicz, Tomasz, Cambiagno, Damian A., Kasprowicz-Maluski, Anna, Smolinski, Dariusz Jan, Mammarella, María Florencia, Ariel, Federico D., Marquardt, Sebastian, Szweykowska-Kulinska, Zofia, Jarmolowski, Artur, Manavella, Pablo A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2022; Nature Publishing Group
• Subjects: 631/208/505; 631/449/1659; Animals; Biomedical and Life Sciences; Biosynthesis; DNA-directed RNA polymerase; Hybrids; Imaging techniques; Life Sciences; Loci; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Plant Sciences; Plants - genetics; Post-transcription; R-Loop Structures; R-loops; Ribonucleic acid; RNA; RNA polymerase; RNA polymerase II; RNA Polymerase II - genetics; RNA Processing, Post-Transcriptional

In most organisms, the maturation of nascent RNAs is coupled to transcription. Unlike in animals, the RNA polymerase II (RNAPII) transcribes microRNA genes ( MIRNA s) as long and structurally variable pri-miRNAs in plants. Current evidence suggests that the miRNA biogenesis complex assembly initiate...