Phytosterols promote liver injury and Kupffer cell activation in parenteral nutrition-associated liver disease

• Published in: Science translational medicine Vol. 5; no. 206; p. 206ra137
• Main Authors: El Kasmi, Karim C, Anderson, Aimee L, Devereaux, Michael W, Vue, Padade M, Zhang, Wujuan, Setchell, Kenneth D R, Karpen, Saul J, Sokol, Ronald J
• Format: Journal Article
• Language: English
• Published: United States 09.10.2013
• Subjects: Animals; Bile - secretion; Bile Canaliculi - drug effects; Bile Canaliculi - metabolism; Bile Canaliculi - pathology; Bone Marrow Cells - drug effects; Bone Marrow Cells - metabolism; Bone Marrow Cells - pathology; Disease Models, Animal; Emulsions; Fish Oils - pharmacology; Gastrointestinal Tract - drug effects; Gastrointestinal Tract - microbiology; Gene Expression Regulation - drug effects; Kupffer Cells - drug effects; Kupffer Cells - metabolism; Kupffer Cells - pathology; Lipids - chemistry; Liver - metabolism; Liver - pathology; Liver Diseases - genetics; Liver Diseases - pathology; Liver Diseases - prevention & control; Macrophage Activation - drug effects; Membrane Transport Proteins - metabolism; Mice; Mice, Inbred C57BL; Microbiota - drug effects; Parenteral Nutrition - adverse effects; Phytosterols - toxicity; Signal Transduction; Solutions; Stigmasterol - blood; Toll-Like Receptor 4 - metabolism

Parenteral nutrition-associated liver disease (PNALD) is a serious complication of PN in infants who do not tolerate enteral feedings, especially those with acquired or congenital intestinal diseases. Yet, the mechanisms underlying PNALD are poorly understood. It has been suggested that a component...