Quercetin inhibits cell viability, migration and invasion by regulating miR-16/HOXA10 axis in oral cancer
Oral cancer is a common tumor malignancy with high mortality and poor prognosis worldwide. Quercetin is one of the major flavonoids present in our daily diet, which is reported to have anti-proliferation and apoptotic effects in varying cancers, including oral cancer. The aim of the present study is...
Saved in:
| Published in | European journal of pharmacology Vol. 847; pp. 11 - 18 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
15.03.2019
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Oral cancer is a common tumor malignancy with high mortality and poor prognosis worldwide. Quercetin is one of the major flavonoids present in our daily diet, which is reported to have anti-proliferation and apoptotic effects in varying cancers, including oral cancer. The aim of the present study is to find the mechanism that underlies the role of quercetin in oral cancer. In this study, cell viability, migration and invasion were measured by MTT, trans-well or western blot assays in oral cancer cells. The levels of microRNA-16 (miR-16) and homeobox A10 (HOXA10) were measured in oral cancer tissues and cells by quantitative real-time polymerase chain reaction (qRT-PCR). The interaction between miR-16 and HOXA10 was probed by luciferase activity, RNA immunoprecipitation (RIP) and western blot. Results showed that quercetin suppressed cell viability, migration, invasion and abundances of metalloproteinase-9 (MMP-9) and MMP-2 in oral cancer cells. miR-16 was down-regulated and reversed by addition of quercetin. Moreover, overexpression of miR-16 also impaired cell viability, migration, invasion and abundances of MMP-9 and MMP-2 in oral cancer cells. Besides, HOXA10 was targeted by miR-16 and its restoration abated miR-16-mediated role in oral cancer. In addition, knockdown of miR-16 reversed the effect of quercetin on progression of oral cancer. Collectively, quercetin inhibited cell viability, migration and invasion by regulating miR-16 and HOXA10 in oral cancer cells. This finding indicated that quercetin might be promising for treatment of oral cancer. |
|---|---|
| AbstractList | Oral cancer is a common tumor malignancy with high mortality and poor prognosis worldwide. Quercetin is one of the major flavonoids present in our daily diet, which is reported to have anti-proliferation and apoptotic effects in varying cancers, including oral cancer. The aim of the present study is to find the mechanism that underlies the role of quercetin in oral cancer. In this study, cell viability, migration and invasion were measured by MTT, trans-well or western blot assays in oral cancer cells. The levels of microRNA-16 (miR-16) and homeobox A10 (HOXA10) were measured in oral cancer tissues and cells by quantitative real-time polymerase chain reaction (qRT-PCR). The interaction between miR-16 and HOXA10 was probed by luciferase activity, RNA immunoprecipitation (RIP) and western blot. Results showed that quercetin suppressed cell viability, migration, invasion and abundances of metalloproteinase-9 (MMP-9) and MMP-2 in oral cancer cells. miR-16 was down-regulated and reversed by addition of quercetin. Moreover, overexpression of miR-16 also impaired cell viability, migration, invasion and abundances of MMP-9 and MMP-2 in oral cancer cells. Besides, HOXA10 was targeted by miR-16 and its restoration abated miR-16-mediated role in oral cancer. In addition, knockdown of miR-16 reversed the effect of quercetin on progression of oral cancer. Collectively, quercetin inhibited cell viability, migration and invasion by regulating miR-16 and HOXA10 in oral cancer cells. This finding indicated that quercetin might be promising for treatment of oral cancer.Oral cancer is a common tumor malignancy with high mortality and poor prognosis worldwide. Quercetin is one of the major flavonoids present in our daily diet, which is reported to have anti-proliferation and apoptotic effects in varying cancers, including oral cancer. The aim of the present study is to find the mechanism that underlies the role of quercetin in oral cancer. In this study, cell viability, migration and invasion were measured by MTT, trans-well or western blot assays in oral cancer cells. The levels of microRNA-16 (miR-16) and homeobox A10 (HOXA10) were measured in oral cancer tissues and cells by quantitative real-time polymerase chain reaction (qRT-PCR). The interaction between miR-16 and HOXA10 was probed by luciferase activity, RNA immunoprecipitation (RIP) and western blot. Results showed that quercetin suppressed cell viability, migration, invasion and abundances of metalloproteinase-9 (MMP-9) and MMP-2 in oral cancer cells. miR-16 was down-regulated and reversed by addition of quercetin. Moreover, overexpression of miR-16 also impaired cell viability, migration, invasion and abundances of MMP-9 and MMP-2 in oral cancer cells. Besides, HOXA10 was targeted by miR-16 and its restoration abated miR-16-mediated role in oral cancer. In addition, knockdown of miR-16 reversed the effect of quercetin on progression of oral cancer. Collectively, quercetin inhibited cell viability, migration and invasion by regulating miR-16 and HOXA10 in oral cancer cells. This finding indicated that quercetin might be promising for treatment of oral cancer. Oral cancer is a common tumor malignancy with high mortality and poor prognosis worldwide. Quercetin is one of the major flavonoids present in our daily diet, which is reported to have anti-proliferation and apoptotic effects in varying cancers, including oral cancer. The aim of the present study is to find the mechanism that underlies the role of quercetin in oral cancer. In this study, cell viability, migration and invasion were measured by MTT, trans-well or western blot assays in oral cancer cells. The levels of microRNA-16 (miR-16) and homeobox A10 (HOXA10) were measured in oral cancer tissues and cells by quantitative real-time polymerase chain reaction (qRT-PCR). The interaction between miR-16 and HOXA10 was probed by luciferase activity, RNA immunoprecipitation (RIP) and western blot. Results showed that quercetin suppressed cell viability, migration, invasion and abundances of metalloproteinase-9 (MMP-9) and MMP-2 in oral cancer cells. miR-16 was down-regulated and reversed by addition of quercetin. Moreover, overexpression of miR-16 also impaired cell viability, migration, invasion and abundances of MMP-9 and MMP-2 in oral cancer cells. Besides, HOXA10 was targeted by miR-16 and its restoration abated miR-16-mediated role in oral cancer. In addition, knockdown of miR-16 reversed the effect of quercetin on progression of oral cancer. Collectively, quercetin inhibited cell viability, migration and invasion by regulating miR-16 and HOXA10 in oral cancer cells. This finding indicated that quercetin might be promising for treatment of oral cancer. |
| Author | Wang, Haibin Zhao, Junfang Zha, Zhian Fang, Zheng Sun, Qiang Qiao, Bin Sun, Minglei |
| Author_xml | – sequence: 1 givenname: Junfang surname: Zhao fullname: Zhao, Junfang – sequence: 2 givenname: Zheng surname: Fang fullname: Fang, Zheng – sequence: 3 givenname: Zhian surname: Zha fullname: Zha, Zhian – sequence: 4 givenname: Qiang surname: Sun fullname: Sun, Qiang – sequence: 5 givenname: Haibin surname: Wang fullname: Wang, Haibin – sequence: 6 givenname: Minglei surname: Sun fullname: Sun, Minglei – sequence: 7 givenname: Bin surname: Qiao fullname: Qiao, Bin email: qiaobin@zzu.edu.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30639311$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkUFv1DAQhS1URLeFf4CQjxxIGMdJHHNAqqpCkSpVRSBxsxxndjurrLPYzor99_WyhQMHehqP_L3RzHtn7MRPHhl7LaAUINr36xLX23sbygqELkGUAO0zthCd0gUoUZ2wBYCoi0prfcrOYlwDQKOr5gU7ldBKLYVYMLqbMThM5Dn5e-opRe5wHPmObE8jpf07vqFVsIkmz60fMraz8dD0ex5wNY_5y68y9LXIW13f_rgQwO0vipnkU7Ajd9Y7DC_Z86UdI756rOfs-6erb5fXxc3t5y-XFzeFq1WdCtlb1zmtndXoUEEjRH4Pts4naeU0SO166drMdYCdUu0SBSqnnJVNX1l5zt4e527D9HPGmMyG4uEk63Gao6mE0rKpqrbL6JtHdO43OJhtoI0Ne_PHngzUR8CFKcaAy7-IAHNIwazNMQVzSMGAMDmFLPvwj8xR-u1gCpbGp8Qfj2LMJu0Ig4mOMDs4UECXzDDR_wc8AG7npUw |
| CitedBy_id | crossref_primary_10_1021_acsomega_0c01818 crossref_primary_10_1016_j_oraloncology_2020_104950 crossref_primary_10_3389_fphar_2023_1273993 crossref_primary_10_1002_bip_23605 crossref_primary_10_3390_ijms241310663 crossref_primary_10_1177_03000605211053158 crossref_primary_10_3389_fgene_2021_758733 crossref_primary_10_1038_s41598_022_04769_z crossref_primary_10_1080_10942912_2023_2252619 crossref_primary_10_1186_s12935_025_03694_1 crossref_primary_10_1002_cbin_11266 crossref_primary_10_2147_CMAR_S250093 crossref_primary_10_3390_antiox11122352 crossref_primary_10_3390_biomedicines11061709 crossref_primary_10_2147_CMAR_S298236 crossref_primary_10_1016_j_envres_2023_116934 crossref_primary_10_3390_ijms23010433 crossref_primary_10_2174_1381612826666201019102207 crossref_primary_10_2174_0109298673256601231009054714 crossref_primary_10_3892_etm_2021_10307 crossref_primary_10_1007_s10142_024_01473_1 crossref_primary_10_1016_j_bcp_2021_114409 crossref_primary_10_1016_j_phrs_2019_104346 crossref_primary_10_3390_nu16010160 crossref_primary_10_3390_cancers11050631 crossref_primary_10_2174_1871520620666200310091719 crossref_primary_10_1186_s13578_020_00397_0 crossref_primary_10_2147_DDDT_S265066 crossref_primary_10_1166_jbn_2023_3703 crossref_primary_10_1016_j_job_2021_01_001 crossref_primary_10_1055_s_0044_1789016 crossref_primary_10_1111_jop_13225 crossref_primary_10_1515_tjb_2023_0003 crossref_primary_10_1186_s12935_020_01700_2 crossref_primary_10_1016_j_phrs_2020_105199 crossref_primary_10_1155_2022_4330681 crossref_primary_10_1007_s12013_025_01697_3 crossref_primary_10_1016_j_micron_2021_103152 crossref_primary_10_1186_s12935_022_02677_w crossref_primary_10_3389_fgene_2022_890079 crossref_primary_10_1016_j_envres_2023_116432 crossref_primary_10_1016_j_prp_2022_154166 crossref_primary_10_3389_fphar_2022_860209 crossref_primary_10_1097_CMR_0000000000000743 crossref_primary_10_3390_biomedicines12040794 crossref_primary_10_3390_nu13113673 crossref_primary_10_1093_jb_mvad070 crossref_primary_10_1016_j_heliyon_2025_e42682 crossref_primary_10_3390_cancers16183193 crossref_primary_10_3390_molecules27123816 crossref_primary_10_1080_10408398_2023_2278760 crossref_primary_10_3390_molecules29071594 crossref_primary_10_1002_slct_202303167 crossref_primary_10_1111_jop_13497 crossref_primary_10_1186_s12935_023_03081_8 crossref_primary_10_3390_molecules25204712 crossref_primary_10_1016_j_drudis_2019_11_001 crossref_primary_10_3390_molecules25030757 crossref_primary_10_3390_ph14020086 crossref_primary_10_3390_bioengineering9050197 crossref_primary_10_1155_2022_3997190 crossref_primary_10_1016_j_oor_2024_100247 crossref_primary_10_1016_j_tibs_2019_06_007 crossref_primary_10_1080_08923973_2021_1966032 crossref_primary_10_1016_j_brainresbull_2021_06_023 crossref_primary_10_1016_j_taap_2021_115467 crossref_primary_10_1111_fcp_12514 crossref_primary_10_1002_mnfr_202100991 crossref_primary_10_3390_molecules25112569 crossref_primary_10_1016_j_bbadis_2022_166552 crossref_primary_10_1016_j_biopha_2020_110372 crossref_primary_10_1080_13813455_2020_1773864 crossref_primary_10_4162_nrp_2021_15_4_444 crossref_primary_10_1186_s11658_021_00301_9 crossref_primary_10_1016_j_cellsig_2023_110667 crossref_primary_10_1017_S0022149X24000877 crossref_primary_10_1002_iub_2242 |
| Cites_doi | 10.1038/nm.3391 10.1007/s00784-017-2317-6 10.1007/s11010-014-2317-7 10.2147/OTT.S153888 10.1177/0022034518762090 10.3390/nu7064578 10.1016/j.oraloncology.2017.11.014 10.1016/j.jcma.2012.11.008 10.3390/molecules21010108 10.3322/caac.21442 10.1158/1541-7786.MCR-17-0655 10.1006/meth.2001.1262 10.3390/nu8090529 10.1207/s15327914nc5302_11 10.1002/ptr.6155 10.1002/jcp.26833 10.1080/01635581.2015.965334 10.1159/000491894 10.1016/j.oraloncology.2014.11.019 10.1002/jcb.27488 |
| ContentType | Journal Article |
| Copyright | 2019 Elsevier B.V. Copyright © 2019 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2019 Elsevier B.V. – notice: Copyright © 2019 Elsevier B.V. All rights reserved. |
| DBID | AAYXX CITATION NPM 7X8 |
| DOI | 10.1016/j.ejphar.2019.01.006 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1879-0712 |
| EndPage | 18 |
| ExternalDocumentID | 30639311 10_1016_j_ejphar_2019_01_006 S0014299919300147 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M -~X .~1 0R~ 1B1 1RT 1~. 1~5 4.4 457 4G. 5GY 5RE 7-5 71M 8P~ 9JM AABNK AACTN AADPK AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AATCM AAXLA AAXUO ABCQJ ABFNM ABFRF ABJNI ABMAC ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGUBO AGWIK AGYEJ AIEXJ AIKHN AITUG AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC C45 CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA HMQ IHE J1W K-O KOM L7B M2V M34 M41 MO0 MOBAO N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SDF SDG SDP SES SPCBC SSN SSP T5K TEORI ~G- .55 .GJ 29G 3O- 53G 5VS AAQFI AAQXK AATTM AAXKI AAYWO AAYXX ABWVN ABXDB ACRPL ACVFH ADCNI ADMUD ADNMO AEIPS AEUPX AFJKZ AFPUW AGCQF AGHFR AGQPQ AGRNS AHHHB AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP ASPBG AVWKF AZFZN BNPGV CITATION FEDTE FGOYB G-2 HMT HVGLF HZ~ R2- SEW SNS SPT SSH SSZ WUQ X7M ZGI NPM 7X8 EFKBS |
| ID | FETCH-LOGICAL-c474t-3bac8c99ca9ece705119cada471297c9039cb3c63ba80e8776fe1e7c7ca35b2a3 |
| IEDL.DBID | .~1 |
| ISSN | 0014-2999 1879-0712 |
| IngestDate | Mon Jul 21 09:21:35 EDT 2025 Thu Apr 03 07:10:41 EDT 2025 Thu Apr 24 23:05:01 EDT 2025 Tue Jul 01 02:50:29 EDT 2025 Fri Feb 23 02:26:04 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | HOXA10 Oral cancer Migration MiR-16 Invasion Quercetin |
| Language | English |
| License | Copyright © 2019 Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c474t-3bac8c99ca9ece705119cada471297c9039cb3c63ba80e8776fe1e7c7ca35b2a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://doi.org/10.1016/j.ejphar.2019.01.006 |
| PMID | 30639311 |
| PQID | 2179352268 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_2179352268 pubmed_primary_30639311 crossref_primary_10_1016_j_ejphar_2019_01_006 crossref_citationtrail_10_1016_j_ejphar_2019_01_006 elsevier_sciencedirect_doi_10_1016_j_ejphar_2019_01_006 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-03-15 |
| PublicationDateYYYYMMDD | 2019-03-15 |
| PublicationDate_xml | – month: 03 year: 2019 text: 2019-03-15 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | European journal of pharmacology |
| PublicationTitleAlternate | Eur J Pharmacol |
| PublicationYear | 2019 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Liu, Jiang, Wan, Zhou, Thapa, Cheng (bib13) 2018; 18 Wang, Li (bib27) 2018 Jiao, Wang, Wang (bib9) 2018; 22 Shao, Chen, Peng, Soutto, Zhu, Bates, Zhang, El-Rifai (bib19) 2018; 16 Khan, Niaz, Maqbool, Ismail Hassan, Abdollahi, Nagulapalli Venkata, Nabavi, Bishayee (bib10) 2016; 8 Chen, Nien, Wu, Liu, Chang, Lin (bib3) 2013; 76 Shen, Zhao, Du (bib20) 2017; 21 Libório-Kimura, Jung, Chan (bib12) 2015; 51 Troiano, Mastrangelo, Caponio, Laino, Cirillo, Lo Muzio (bib24) 2018; 97 Farooqi, Jabeen, Attar, Yaylim, Xu (bib4) 2018 Cao, Zheng, Liu, Dobleman, Hu, Go, Gao, Xiao (bib1) 2018; 22 Wang, Sun-Waterhouse, Li, Xin, Li (bib26) 2018 Carrera, Bitu, de Oliveira, Cervigne, Graner, Manninen, Salo, Coletta (bib2) 2015; 8 Guo, Ding, Xu, Ge, Jiang, Chen, Lu (bib6) 2018 Fu, He, Wang, Peng, Chen, Li, Wan (bib5) 2018; 48 Jiang, Wang (bib8) 2018; 16 Siegel, Miller, Jemal (bib21) 2018; 68 Rauf, Imran, Khan, Ur-Rehman, Gilani, Mehmood, Mubarak (bib18) 2018 Wan, Pantel, Kang (bib25) 2013; 19 Marcazzan, Varoni, Blanco, Lodi, Ferrari (bib16) 2018; 76 Haghiac, Walle (bib7) 2005; 53 Liu, Jiang, Zhao, Wen (bib14) 2018; 11 Livak, Schmittgen (bib15) 2001; 25 Lai, Hsu, Chueh, Chen, Yang, Lin, Lien, Tsai, Chung (bib11) 2013; 33 Nam, Sharma, Nquyen, Chakraborty, Sharma, Lee (bib17) 2016; 21 Sonoki, Sato, Endo, Matsunaga, Yamaguchi, Yamazaki, Sugatani, Ikari (bib22) 2015; 7 Tao, He, Chen (bib23) 2015; 402 Yuan, Wang, Hu, Huang, Yao, Sun, Wu (bib29) 2015; 67 Yamatoji, Kasamatsu, Yamano, Sakuma, Ogoshi, Iyoda, Shinozuka, Ogawara, Takiguchi, Shiiba, Tanzawa, Uzawa (bib28) 2010; 23 Shen (10.1016/j.ejphar.2019.01.006_bib20) 2017; 21 Cao (10.1016/j.ejphar.2019.01.006_bib1) 2018; 22 Liu (10.1016/j.ejphar.2019.01.006_bib14) 2018; 11 Marcazzan (10.1016/j.ejphar.2019.01.006_bib16) 2018; 76 Chen (10.1016/j.ejphar.2019.01.006_bib3) 2013; 76 Wang (10.1016/j.ejphar.2019.01.006_bib26) 2018 Lai (10.1016/j.ejphar.2019.01.006_bib11) 2013; 33 Farooqi (10.1016/j.ejphar.2019.01.006_bib4) 2018 Rauf (10.1016/j.ejphar.2019.01.006_bib18) 2018 Tao (10.1016/j.ejphar.2019.01.006_bib23) 2015; 402 Yamatoji (10.1016/j.ejphar.2019.01.006_bib28) 2010; 23 Liu (10.1016/j.ejphar.2019.01.006_bib13) 2018; 18 Guo (10.1016/j.ejphar.2019.01.006_bib6) 2018 Nam (10.1016/j.ejphar.2019.01.006_bib17) 2016; 21 Wang (10.1016/j.ejphar.2019.01.006_bib27) 2018 Wan (10.1016/j.ejphar.2019.01.006_bib25) 2013; 19 Libório-Kimura (10.1016/j.ejphar.2019.01.006_bib12) 2015; 51 Carrera (10.1016/j.ejphar.2019.01.006_bib2) 2015; 8 Shao (10.1016/j.ejphar.2019.01.006_bib19) 2018; 16 Troiano (10.1016/j.ejphar.2019.01.006_bib24) 2018; 97 Haghiac (10.1016/j.ejphar.2019.01.006_bib7) 2005; 53 Fu (10.1016/j.ejphar.2019.01.006_bib5) 2018; 48 Sonoki (10.1016/j.ejphar.2019.01.006_bib22) 2015; 7 Yuan (10.1016/j.ejphar.2019.01.006_bib29) 2015; 67 Khan (10.1016/j.ejphar.2019.01.006_bib10) 2016; 8 Siegel (10.1016/j.ejphar.2019.01.006_bib21) 2018; 68 Jiang (10.1016/j.ejphar.2019.01.006_bib8) 2018; 16 Livak (10.1016/j.ejphar.2019.01.006_bib15) 2001; 25 Jiao (10.1016/j.ejphar.2019.01.006_bib9) 2018; 22 |
| References_xml | – volume: 48 start-page: 670 year: 2018 end-page: 682 ident: bib5 article-title: MicroRNA-16 promotes ovarian granulosa cell proliferation and suppresses apoptosis through targeting PDCD4 in polycystic ovarian syndrome publication-title: Cell. Physiol. Biochem. – volume: 68 start-page: 7 year: 2018 end-page: 30 ident: bib21 article-title: Cancer statistics, 2018 publication-title: CA Cancer J. Clin. – volume: 53 start-page: 220 year: 2005 end-page: 231 ident: bib7 article-title: Quercetin induces necrosis and apoptosis in SCC-9 oral cancer cells publication-title: Nutr. Cancer – volume: 16 start-page: 3005 year: 2018 end-page: 3012 ident: bib8 article-title: miR-16 targets SALL4 to repress the proliferation and migration of gastric cancer publication-title: Oncol. Lett. – volume: 11 start-page: 5111 year: 2018 end-page: 5119 ident: bib14 article-title: MiRNA-16 inhibited oral squamous carcinoma tumor growth in vitro and in vivo via suppressing Wnt/β-catenin signaling pathway publication-title: OncoTargets Ther. – volume: 22 start-page: 2598 year: 2018 end-page: 2605 ident: bib9 article-title: MicroRNA-16 suppressed the invasion and migration of osteosarcoma by directly inhibiting RAB23 publication-title: Eur. Rev. Med. Pharmacol. Sci. – volume: 33 start-page: 1941 year: 2013 end-page: 1950 ident: bib11 article-title: Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways publication-title: Anticancer Res. – volume: 76 start-page: 1 year: 2018 end-page: 7 ident: bib16 article-title: Nanomedicine, an emerging therapeutic strategy for oral cancer therapy publication-title: Oral. Oncol. – year: 2018 ident: bib27 article-title: MicroRNA-16 functions as a tumor-suppressor gene in oral squamous cell carcinoma by targeting AKT3 and BCL2L2 publication-title: J. Cell. Physiol. – volume: 67 start-page: 126 year: 2015 end-page: 136 ident: bib29 article-title: Quercetin inhibits proliferation and drug resistance in KB/VCR oral cancer cells and enhances its sensitivity to vincristine publication-title: Nutr. Cancer – volume: 22 start-page: 571 year: 2018 end-page: 581 ident: bib1 article-title: MicroRNAs as effective surrogate biomarkers for early diagnosis of oral cancer publication-title: Clin. Oral. Investig. – volume: 16 start-page: 696 year: 2018 end-page: 706 ident: bib19 article-title: Methylation of the HOXA10 promoter directs miR-196b-5p-dependent cell proliferation and invasion of gastric cancer cells publication-title: Mol. Cancer Res. – volume: 21 start-page: 108 year: 2016 ident: bib17 article-title: Application of bioactive quercetin in oncotherapy: from nutrition to nanomedicine publication-title: Molecules – volume: 402 start-page: 93 year: 2015 end-page: 100 ident: bib23 article-title: Quercetin inhibits proliferation and invasion acts by up-regulating miR-146a in human breast cancer cells publication-title: Mol. Cell. Biochem. – start-page: 1 year: 2018 end-page: 13 ident: bib26 article-title: MicroRNAs as molecular targets of quercetin and its derivatives underlying their biological effects: a preclinical strategy publication-title: Crit. Rev. Food Sci. Nutr. – volume: 7 start-page: 4578 year: 2015 end-page: 4592 ident: bib22 article-title: Quercetin decreases claudin-2 expression mediated by up-regulation of microRNA miR-16 in lung adenocarcinoma A549 cells publication-title: Nutrients – volume: 19 start-page: 1450 year: 2013 end-page: 1464 ident: bib25 article-title: Tumor metastasis: moving new biological insights into the clinic publication-title: Nat. Med. – volume: 51 start-page: 151 year: 2015 end-page: 157 ident: bib12 article-title: miR-494 represses HOXA10 expression and inhibits cell proliferation in oral cancer publication-title: Oral. Oncol. – volume: 25 start-page: 402 year: 2001 end-page: 408 ident: bib15 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2 −ΔΔ C T method publication-title: Methods – volume: 23 start-page: 61 year: 2010 end-page: 67 ident: bib28 article-title: State of homeobox A10 expression as a putative prognostic marker for oral squamous cell carcinoma publication-title: Oncol. Rep. – volume: 8 start-page: 529 year: 2016 ident: bib10 article-title: Molecular targets underlying the anticancer effects of quercetin: an update publication-title: Nutrients – volume: 21 start-page: 945 year: 2017 end-page: 952 ident: bib20 article-title: HOXA10 promotes nasopharyngeal carcinoma cell proliferation and invasion via inducing the expression of ZIC2 publication-title: Eur. Rev. Med. Pharmacol. Sci. – volume: 8 start-page: 3613 year: 2015 end-page: 3623 ident: bib2 article-title: HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma publication-title: Int. J. Clin. Exp. Pathol. – start-page: 1 year: 2018 end-page: 28 ident: bib6 article-title: MiR-135a-5p represses proliferation of HNSCC by targeting HOXA10 publication-title: Cancer Biol. Ther. – year: 2018 ident: bib18 article-title: Anticancer potential of quercetin: a comprehensive review publication-title: Phytother. Res. – volume: 97 start-page: 759 year: 2018 end-page: 766 ident: bib24 article-title: Predictive prognostic value of tissue-based microRNA expression in oral squamous cell carcinoma: a systematic review and meta-analysis publication-title: J. Dent. Res. – volume: 76 start-page: 146 year: 2013 end-page: 152 ident: bib3 article-title: Reappraisal of the anticancer efficacy of quercetin in oral cancer cells publication-title: J. Chin. Med. Assoc. – year: 2018 ident: bib4 article-title: Quercetin-mediated regulation of signal transduction cascades and microRNAs: natural weapon against cancer publication-title: J. Cell. Biochem. – volume: 18 start-page: 2661 year: 2018 end-page: 2668 ident: bib13 article-title: MicroRNA‑665 suppresses the growth and migration of ovarian cancer cells by targeting HOXA10 publication-title: Mol. Med. Rep. – start-page: 1 year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib26 article-title: MicroRNAs as molecular targets of quercetin and its derivatives underlying their biological effects: a preclinical strategy publication-title: Crit. Rev. Food Sci. Nutr. – volume: 19 start-page: 1450 year: 2013 ident: 10.1016/j.ejphar.2019.01.006_bib25 article-title: Tumor metastasis: moving new biological insights into the clinic publication-title: Nat. Med. doi: 10.1038/nm.3391 – volume: 22 start-page: 571 year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib1 article-title: MicroRNAs as effective surrogate biomarkers for early diagnosis of oral cancer publication-title: Clin. Oral. Investig. doi: 10.1007/s00784-017-2317-6 – volume: 402 start-page: 93 year: 2015 ident: 10.1016/j.ejphar.2019.01.006_bib23 article-title: Quercetin inhibits proliferation and invasion acts by up-regulating miR-146a in human breast cancer cells publication-title: Mol. Cell. Biochem. doi: 10.1007/s11010-014-2317-7 – volume: 11 start-page: 5111 year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib14 article-title: MiRNA-16 inhibited oral squamous carcinoma tumor growth in vitro and in vivo via suppressing Wnt/β-catenin signaling pathway publication-title: OncoTargets Ther. doi: 10.2147/OTT.S153888 – volume: 97 start-page: 759 year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib24 article-title: Predictive prognostic value of tissue-based microRNA expression in oral squamous cell carcinoma: a systematic review and meta-analysis publication-title: J. Dent. Res. doi: 10.1177/0022034518762090 – volume: 7 start-page: 4578 year: 2015 ident: 10.1016/j.ejphar.2019.01.006_bib22 article-title: Quercetin decreases claudin-2 expression mediated by up-regulation of microRNA miR-16 in lung adenocarcinoma A549 cells publication-title: Nutrients doi: 10.3390/nu7064578 – volume: 76 start-page: 1 year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib16 article-title: Nanomedicine, an emerging therapeutic strategy for oral cancer therapy publication-title: Oral. Oncol. doi: 10.1016/j.oraloncology.2017.11.014 – volume: 76 start-page: 146 year: 2013 ident: 10.1016/j.ejphar.2019.01.006_bib3 article-title: Reappraisal of the anticancer efficacy of quercetin in oral cancer cells publication-title: J. Chin. Med. Assoc. doi: 10.1016/j.jcma.2012.11.008 – volume: 21 start-page: 108 year: 2016 ident: 10.1016/j.ejphar.2019.01.006_bib17 article-title: Application of bioactive quercetin in oncotherapy: from nutrition to nanomedicine publication-title: Molecules doi: 10.3390/molecules21010108 – volume: 23 start-page: 61 year: 2010 ident: 10.1016/j.ejphar.2019.01.006_bib28 article-title: State of homeobox A10 expression as a putative prognostic marker for oral squamous cell carcinoma publication-title: Oncol. Rep. – volume: 68 start-page: 7 year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib21 article-title: Cancer statistics, 2018 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21442 – volume: 16 start-page: 696 year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib19 article-title: Methylation of the HOXA10 promoter directs miR-196b-5p-dependent cell proliferation and invasion of gastric cancer cells publication-title: Mol. Cancer Res. doi: 10.1158/1541-7786.MCR-17-0655 – volume: 25 start-page: 402 year: 2001 ident: 10.1016/j.ejphar.2019.01.006_bib15 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2 −ΔΔ C T method publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 8 start-page: 3613 year: 2015 ident: 10.1016/j.ejphar.2019.01.006_bib2 article-title: HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma publication-title: Int. J. Clin. Exp. Pathol. – start-page: 1 year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib6 article-title: MiR-135a-5p represses proliferation of HNSCC by targeting HOXA10 publication-title: Cancer Biol. Ther. – volume: 33 start-page: 1941 year: 2013 ident: 10.1016/j.ejphar.2019.01.006_bib11 article-title: Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways publication-title: Anticancer Res. – volume: 8 start-page: 529 year: 2016 ident: 10.1016/j.ejphar.2019.01.006_bib10 article-title: Molecular targets underlying the anticancer effects of quercetin: an update publication-title: Nutrients doi: 10.3390/nu8090529 – volume: 53 start-page: 220 year: 2005 ident: 10.1016/j.ejphar.2019.01.006_bib7 article-title: Quercetin induces necrosis and apoptosis in SCC-9 oral cancer cells publication-title: Nutr. Cancer doi: 10.1207/s15327914nc5302_11 – year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib18 article-title: Anticancer potential of quercetin: a comprehensive review publication-title: Phytother. Res. doi: 10.1002/ptr.6155 – year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib27 article-title: MicroRNA-16 functions as a tumor-suppressor gene in oral squamous cell carcinoma by targeting AKT3 and BCL2L2 publication-title: J. Cell. Physiol. doi: 10.1002/jcp.26833 – volume: 16 start-page: 3005 year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib8 article-title: miR-16 targets SALL4 to repress the proliferation and migration of gastric cancer publication-title: Oncol. Lett. – volume: 21 start-page: 945 year: 2017 ident: 10.1016/j.ejphar.2019.01.006_bib20 article-title: HOXA10 promotes nasopharyngeal carcinoma cell proliferation and invasion via inducing the expression of ZIC2 publication-title: Eur. Rev. Med. Pharmacol. Sci. – volume: 67 start-page: 126 year: 2015 ident: 10.1016/j.ejphar.2019.01.006_bib29 article-title: Quercetin inhibits proliferation and drug resistance in KB/VCR oral cancer cells and enhances its sensitivity to vincristine publication-title: Nutr. Cancer doi: 10.1080/01635581.2015.965334 – volume: 22 start-page: 2598 year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib9 article-title: MicroRNA-16 suppressed the invasion and migration of osteosarcoma by directly inhibiting RAB23 publication-title: Eur. Rev. Med. Pharmacol. Sci. – volume: 48 start-page: 670 year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib5 article-title: MicroRNA-16 promotes ovarian granulosa cell proliferation and suppresses apoptosis through targeting PDCD4 in polycystic ovarian syndrome publication-title: Cell. Physiol. Biochem. doi: 10.1159/000491894 – volume: 51 start-page: 151 year: 2015 ident: 10.1016/j.ejphar.2019.01.006_bib12 article-title: miR-494 represses HOXA10 expression and inhibits cell proliferation in oral cancer publication-title: Oral. Oncol. doi: 10.1016/j.oraloncology.2014.11.019 – year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib4 article-title: Quercetin-mediated regulation of signal transduction cascades and microRNAs: natural weapon against cancer publication-title: J. Cell. Biochem. doi: 10.1002/jcb.27488 – volume: 18 start-page: 2661 year: 2018 ident: 10.1016/j.ejphar.2019.01.006_bib13 article-title: MicroRNA‑665 suppresses the growth and migration of ovarian cancer cells by targeting HOXA10 publication-title: Mol. Med. Rep. |
| SSID | ssj0005925 |
| Score | 2.5499432 |
| Snippet | Oral cancer is a common tumor malignancy with high mortality and poor prognosis worldwide. Quercetin is one of the major flavonoids present in our daily diet,... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 11 |
| SubjectTerms | HOXA10 Invasion Migration MiR-16 Oral cancer Quercetin |
| Title | Quercetin inhibits cell viability, migration and invasion by regulating miR-16/HOXA10 axis in oral cancer |
| URI | https://dx.doi.org/10.1016/j.ejphar.2019.01.006 https://www.ncbi.nlm.nih.gov/pubmed/30639311 https://www.proquest.com/docview/2179352268 |
| Volume | 847 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwELUQXHpBBdqyLUWuVHHCYDvOOj6uEGihEh8VSHuzbMcpRm1Y7WZR99LfXk-cQCtRIfWWROPE8bzMjJyZNwh9jop1jleCVCovieAVJ6ooC2LK6CCEibCxbYLs-XB8I84m-WQFHfW1MJBW2dn-ZNNba91dOexW83AaAtT4MjCmKoYgcAgV5UJIQPnBrz_SPBTvuhgIAtJ9-Vyb4-XvprcGWEGZask7oe_R8-7pX-Fn64ZOXqP1Ln7EozTFDbTi6020d5kIqJf7-Pqpnmq-j_fw5RM19XILhasFJLI0ocahvg02NHMMW_f4ISS-7niHH-FbQgU2dRnFHgxsqGG7xLPUtz46uyj0lcR3G19MRoxi8zPMoySGan_sAEezN-jm5Pj6aEy6ZgvECSkaklnjCqeUM8o7Lyn8X3SmNNF5cSWdoplyNnPDKFdQX0g5rDzz0klnstxyk71Fq_V97bcRdoXywuXSiooKy7mRtKyYrCgtId6xA5T1a6xdx0QODTG-6z7l7E4nzWjQjKZMR80MEHkcNU1MHC_Iy159-i9E6egsXhj5qde2jh8bqMHU_n4x1xzMGUSsxQC9SzB4nEsGwV7G2Pv_fu4H9ArOIMON5TtotZkt_McY8jR2t8X0LlobnX4Zn_8GsQoAuA |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swEBdd-rC9jHWf2UenwehTRWVZjqzHUFbctcu6kULehCTLrcrmhsQpy38_nWU3FFYKezP2yZZ157sf8t3vEPocFGstqzipZFYSzipGZF7mRJchQHAdzMa0CbKTUXHOv86y2RY67GthIK2y8_3Rp7feujtz0K3mwdx7qPFNwJnKAEHgUDxC28BOlQ3Q9vj4pJhsMj0k6xoZcAID-gq6Ns3LXc0vNRCDJrLl74TWR_-OUPch0DYSHT1DTzsIicdxljtoy9XP0d5Z5KBe7-PppqRquY_38NmGnXr9AvkfK8hlaXyNfX3pjW-WGHbv8Y2PlN3hDr_9RTQMrOsyiN1o2FPDZo0XsXV9iHdB6CcJ71Z8n40TivUfvwySGAr-sQVTWrxE50dfpocF6fotEMsFb0hqtM2tlFZLZ52g8IvR6lKH-MWksJKm0prUjoJcTl0uxKhyiRNWWJ1mhun0FRrU17V7g7DNpeM2E4ZXlBvGtKBllYiK0hIgjxmitF9jZTsycuiJ8Uv1WWdXKmpGgWYUTVTQzBCR21HzSMbxgLzo1afuGJUK8eKBkZ96bavwvYEadO2uV0vFwKMBaM2H6HU0g9u5pID30iR5-9_P_YgeF9Nvp-r0eHLyDj2BK5DwlmTv0aBZrNyHgIAas9tZ-F91ywNp |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Quercetin+inhibits+cell+viability%2C+migration+and+invasion+by+regulating+miR-16%2FHOXA10+axis+in+oral+cancer&rft.jtitle=European+journal+of+pharmacology&rft.au=Zhao%2C+Junfang&rft.au=Fang%2C+Zheng&rft.au=Zha%2C+Zhian&rft.au=Sun%2C+Qiang&rft.date=2019-03-15&rft.pub=Elsevier+B.V&rft.issn=0014-2999&rft.eissn=1879-0712&rft.volume=847&rft.spage=11&rft.epage=18&rft_id=info:doi/10.1016%2Fj.ejphar.2019.01.006&rft.externalDocID=S0014299919300147 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0014-2999&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0014-2999&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0014-2999&client=summon |