Pilot Pharmacokinetic Study in Healthy Adults Using Intravascular Microdialysis Catheters Modified for Use in Paediatric Patients to Assess Vancomycin Blood Levels

• Published in: Clinical pharmacokinetics Vol. 62; no. 1; pp. 77 - 87
• Main Authors: al Jalali, Valentin, Bauer, Martin, Wölfl-Duchek, Michael, Sarhan, Maysa, Wicha, Sebastian G., Poschner, Stefan, Jäger, Walter, König, Franz, Male, Christoph, Zeitlinger, Markus
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.01.2023; Springer Nature B.V
• Subjects: Adult; Anti-Bacterial Agents - pharmacokinetics; Antibiotics; Blood; Catheters; Child; Clinical medicine; Drug dosages; Experiments; Hemodialysis; Humans; Internal Medicine; Medical research; Medicine; Medicine & Public Health; Microdialysis - methods; Original; Original Research Article; Pediatrics; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Phlebotomy; Physiology; Plasma; Prospective Studies; Vancomycin

Background and Objective Exhaustive pharmacokinetic (PK) studies in paediatric patients are unavailable for most antibiotics and feasibility of PK studies is limited by challenges, such as low blood volume and venipuncture-related pain. Microdialysis (MD) represents a promising method to overcome th...