Efficacy and toxicity of KRASG12C inhibitors in advanced solid tumors: a meta-analysis

• Published in: World journal of surgical oncology Vol. 22; no. 1; pp. 182 - 12
• Main Authors: Dang, Shoutao, Zhang, Shuyang, Zhao, Jingyang, Li, Wei
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 16.07.2024; BioMed Central; BMC
• Subjects: Analysis; Cancer; Care and treatment; Complications and side effects; Enzyme inhibitors; KRASG12C inhibitors; Medical research; Medicine, Experimental; Meta-analysis; Online databases; Panitumumab; Physiological aspects; Solid tumors; Testing; Tumors; China

Background The efficacy and toxicity of KRAS.sup.G12C inhibitors were evaluated for advanced solid tumors in several studies; however, the results were not fully consistent. Methods Clinical trials evaluating KRAS.sup.G12C inhibitors for advanced solid tumors were searched from PubMed, Embase, and C...