Caloric restriction disrupts the microbiota and colonization resistance

• Published in: Nature (London) Vol. 595; no. 7866; pp. 272 - 277
• Main Authors: von Schwartzenberg, Reiner Jumpertz, Bisanz, Jordan E., Lyalina, Svetlana, Spanogiannopoulos, Peter, Ang, Qi Yan, Cai, Jingwei, Dickmann, Sophia, Friedrich, Marie, Liu, Su-Yang, Collins, Stephanie L., Ingebrigtsen, Danielle, Miller, Steve, Turnbaugh, Jessie A., Patterson, Andrew D., Pollard, Katherine S., Mai, Knut, Spranger, Joachim, Turnbaugh, Peter J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.07.2021; Nature Publishing Group
• Subjects: 38; 45; 45/23; 631/326/2565/2134; 631/443/319/1642/2037; 64; 64/60; 692/700/2814; Adipose tissue; Adiposity; Animals; Bacteria; Bacteria - growth & development; Bacteria - isolation & purification; Bacteria - metabolism; Bacteria - pathogenicity; Bacterial Toxins - metabolism; Bile acids; Bile Acids and Salts - metabolism; Body Weight; Body weight loss; Caloric Restriction; Calories; Clostridioides difficile - growth & development; Clostridioides difficile - isolation & purification; Clostridioides difficile - metabolism; Colonization; Diet; Diet, Reducing; Dietary restrictions; Energy balance; Energy Metabolism; Enzymes; Gastrointestinal Microbiome - physiology; Genes; Glucose; Humanities and Social Sciences; Humans; Hypocaloric diet; Intestinal Absorption; Intestinal microflora; Male; Metabolism; Mice; Microbiomes; Microbiota; multidisciplinary; Nutrient deficiency; Nutrient loss; Nutrients - metabolism; Phenotypes; Science; Science (multidisciplinary); Symbionts; Symbiosis; Toxins; Transplantation; Weight control; Weight Loss

Diet is a major factor that shapes the gut microbiome 1 , but the consequences of diet-induced changes in the microbiome for host pathophysiology remain poorly understood. We conducted a randomized human intervention study using a very-low-calorie diet (NCT01105143). Although metabolic health was im...