NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity - Gu, Meidi; Zhou, Xiaofei; Sohn, Jee Hyung; Zhu, Lele; Jie, Zuliang; Yang, Jin-Young; Zheng, Xiaofeng; Xie, Xiaoping; Yang, Jie; Shi, Yaoyao; Brightbill, Hans D.; Kim, Jae Bum; et al. (Nature immunology, 2021)
Keywords: 631/250/516; 631/250/580; Animals; Antioxidants; Antitumor activity; Biomedical and Life Sciences; Biomedicine; CD8 antigen; CD8-Positive T-Lymphocytes - enzymology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - transplantation; Cell Line, Tumor; Colonic Neoplasms - enzymology; Colonic Neoplasms - immunology; Colonic Neoplasms - pathology; Colonic Neoplasms - therapy; Cytotoxicity; Cytotoxicity, Immunologic; Ectopic expression; Effector cells; Energy Metabolism; Enzyme Stability; Enzymes; Female; Fitness; Glucosephosphate dehydrogenase; Glucosephosphate Dehydrogenase - metabolism; Glycolysis; Hexokinase; Hexokinase - genetics; Hexokinase - metabolism; Immunity; Immunology; Immunotherapy, Adoptive; Infectious Diseases; Kinases; Lymphocyte Activation; Lymphocytes; Lymphocytes T; Lymphocytes, Tumor-Infiltrating - enzymology; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - transplantation; Male; Melanoma, Experimental - enzymology; Melanoma, Experimental - immunology; Melanoma, Experimental - pathology; Melanoma, Experimental - therapy; Metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; NADP - metabolism; NF-kappaB-Inducing Kinase; NF-κB protein; Phenotype; Post-translation; Protein Serine-Threonine Kinases - deficiency; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Reactive oxygen species; Reactive Oxygen Species - metabolism; Signal Transduction; Tumor Microenvironment