Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion

• Published in: Journal of molecular neuroscience Vol. 70; no. 6; pp. 930 - 944
• Main Authors: Edvinsson, Lars, Grell, Anne-Sofie, Warfvinge, Karin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2020; Springer Nature B.V
• Subjects: Adrenomedullin; Amylin; Animals; Antibodies; Biomedical and Life Sciences; Biomedicine; Calcitonin; Calcitonin gene-related peptide; Calcitonin Gene-Related Peptide - genetics; Calcitonin Gene-Related Peptide - metabolism; Cell Biology; Cross-reactivity; Cytoplasm; Drug development; Fibers; Gene expression; Glial cells; Headache; Immunohistochemistry; Male; Neurochemistry; Neurology; Neuronal-glial interactions; Neurons; Neuropeptides; Neurosciences; Peptides; Procalcitonin; Proteins; Proteomics; Ramps; Rats; Rats, Sprague-Dawley; Receptor activity modifying proteins; Receptor Activity-Modifying Proteins - genetics; Receptor Activity-Modifying Proteins - metabolism; Receptors; Receptors, Calcitonin - genetics; Receptors, Calcitonin - metabolism; Receptors, Calcitonin Gene-Related Peptide - genetics; Receptors, Calcitonin Gene-Related Peptide - metabolism; Schwann cells; Trigeminal ganglion; Trigeminal Ganglion - metabolism; Immunohistochemistry; CGRP peptides family; Ligands; Receptors; qPCR; mRNA analysis

The calcitonin gene-related peptide (CGRP) family of neuropeptides, consists of CGRP, adrenomedullin, amylin, and calcitonin. The receptors consist of either calcitonin receptor-like receptor (CLR) or calcitonin receptor (CTR) which for function needs an accessory protein, receptor activity-modifyin...