Sediment pollutant exposures caused hepatotoxicity and disturbed glycogenesis

• Published in: Ecotoxicology and environmental safety Vol. 251; p. 114559
• Main Authors: Lin, Meng-Wei, Yu, Xin-Ru, Chen, Jai-Yu, Wei, Yu-Shan, Chen, Hsin-Yi, Tsai, Yi-Ting, Lin, Li-Hsun, Liao, En-Chi, Kung, Hsiang-Yu, Young, Shuh-Sen, Chan, Hong-Lin, Chou, Hsiu-Chuan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.02.2023; Elsevier
• Subjects: Apoptosis; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - metabolism; Environmental Pollutants - metabolism; Environmental pollution; Glycogen Synthase - metabolism; Glycogen Synthase - pharmacology; Glycogenesis; Humans; Liver; Liver damage; Liver Glycogen - metabolism; Liver Glycogen - pharmacology; Sediment; DMSO; IRS-1; Liver damage; GPT; BSA; DMEM; SD; DSE; GYS; PBS; Glycogenesis; Sediment; HSP; Environmental pollution; IR; Ctrl; GOT; PVDF; DCM; GSK3β; SDS-PAGE; APF; FCS; ROS; Apoptosis

Liver metabolic syndrome, which involves impaired hepatic glycogen synthesis, is persistently increased by exposure to environmental pollutants. Most studies have investigated the pathogenesis of liver damage caused by single metal species or pure organics. However, under normal circumstances, the p...