Stereocontrolled 1,3-nitrogen migration to access chiral α-amino acids

• Published in: Nature chemistry Vol. 14; no. 5; pp. 566 - 573
• Main Authors: Ye, Chen-Xi, Shen, Xiang, Chen, Shuming, Meggers, Eric
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2022; NATURE PORTFOLIO; Nature Publishing Group
• Subjects: 639/638/403/933; 639/638/549/933; 639/638/549/972; 639/638/77/883; Amination; Amines - chemistry; Amino acids; Amino Acids - chemistry; Analytical Chemistry; Aromatic compounds; Biochemistry; Carboxylic acids; Catalysis; Chains; Chemistry; Chemistry and Materials Science; Chemistry, Multidisciplinary; Chemistry/Food Science; Drugs; Enantiomers; Inorganic Chemistry; Natural products; Nitrogen; Nitrogen - chemistry; Nitrogenation; Optical activity; Organic Chemistry; Physical Chemistry; Physical Sciences; Reagents; Ruthenium; Science & Technology; Stereoisomerism; AMIDATION; CHEMISTRY; RUTHENIUM; IRON; CATALYST; C-H AMINATION; METAL-COMPLEXES

α-Amino acids are essential for life as building blocks of proteins and components of diverse natural molecules. In both industry and academia, the incorporation of unnatural amino acids is often desirable for modulating chemical, physical and pharmaceutical properties. Here we report a protocol for...