Deregulation of TLR4 signaling pathway characterizes Bicuspid Aortic valve syndrome

• Published in: Scientific reports Vol. 9; no. 1; pp. 11028 - 8
• Main Authors: Balistreri, Carmela R., Marullo, Antonino G. M., Madonna, Michele, Cavarretta, Elena, Allegra, Alberto, Cesarini, Valeriana, Iaccarino, Alessandra, Schiavon, Sonia, Peruzzi, Mariangela, Greco, Ernesto, Sciarretta, Sebastiano, Pisano, Calogera, Ruvolo, Giovanni, Torella, Michele, Frati, Giacomo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.07.2019; Nature Publishing Group
• Subjects: 38; 692/4019; 692/4019/592/75/591; Aged; Aged, 80 and over; Aorta; Aorta - metabolism; Aortic valve; Aortic Valve - abnormalities; Aortic Valve - metabolism; Bicuspid Aortic Valve Disease; Cytokines; Deregulation; Evolutionary conservation; Female; Gene expression; Heart Valve Diseases - metabolism; Homeostasis; Humanities and Social Sciences; Humans; Inflammation; Interleukin 1; Interleukin 17; Interleukin 6; Interleukins - blood; Interleukins - genetics; Interleukins - metabolism; Male; Middle Aged; multidisciplinary; Notch1 protein; Science; Science (multidisciplinary); Signal Transduction; Syndrome; TLR4 protein; Toll-Like Receptor 4 - blood; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-α; Variance analysis

Bicuspid aortic valve (BAV) disease is recognized to be a syndrome with a complex and multifaceted pathophysiology. Its progression is modulated by diverse evolutionary conserved pathways, such as Notch-1 pathway. Emerging evidence is also highlighting the key role of TLR4 signaling pathway in the a...