Extracellular histones are a target in myocardial ischaemia–reperfusion injury

• Published in: Cardiovascular research Vol. 118; no. 4; pp. 1115 - 1125
• Main Authors: Shah, Mohammed, He, Zhenhe, Rauf, Ali, Beikoghli Kalkhoran, Siavash, Heiestad, Christina Mathisen, Stensløkken, Kåre-Olav, Parish, Christopher R, Soehnlein, Oliver, Arjun, Sapna, Davidson, Sean M, Yellon, Derek
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 16.03.2022
• Subjects: Animals; HEK293 Cells; Histones - metabolism; Humans; Myocardial Infarction - metabolism; Myocardial Infarction - prevention & control; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - prevention & control; Myocardium - metabolism; Myocytes, Cardiac - metabolism; Original; Rats; Toll-Like Receptor 4 - metabolism; Ischaemia; Histones; Cardiomyocyte death; Reperfusion; DAMPs

Abstract Aims  Acute myocardial infarction causes lethal cardiomyocyte injury during ischaemia and reperfusion (I/R). Histones have been described as important Danger Associated Molecular Proteins (DAMPs) in sepsis. The objective of this study was to establish whether extracellular histone release c...