Tris(2-ethylhexyl) phosphate induces cytotoxicity in TM3 Leydig cells by modulating autophagy and endoplasmic reticulum stress

• Published in: Ecotoxicology and environmental safety Vol. 279; p. 116462
• Main Authors: Zhang, Wenqiao, Song, Yali, Yi, Letai, Ou, Jinhuan, Chen, Junhui, Zhang, Wei, Wen, Qinglian, Yang, Chuanbin, Wang, Jigang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.07.2024; Elsevier
• Subjects: Animals; Apoptosis - drug effects; Autophagy; Autophagy - drug effects; Cell Line; Endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; Flame Retardants - toxicity; Leydig Cells - drug effects; Male; Mice; Reproductive toxicity; Tris (2-ethylhexyl) phosphate; Tris (2-ethylhexyl) phosphate; Autophagy; Reproductive toxicity; Endoplasmic reticulum stress

Tris (2-ethylhexyl) phosphate (TEHP) is a frequently used organophosphorus flame retardant with significant ecotoxicity and widespread human exposure. Recent research indicates that TEHP has reproductive toxicity. However, the precise cell mechanism is not enough understood. Here, by using testicula...