The synergistic mechanism of total saponins and flavonoids in Notoginseng−Safflower pair against myocardial ischemia uncovered by an integrated metabolomics strategy
[Display omitted] •Holistic and integrated strategy to investigate the compatibility of TCM herbal pair.•NS and SF showed different effect on ameliorating MI-related metabolic alterations.•NS showed greater effect on reversing proinflammatory signals than SF.•SF exhibited better effect on decreasing...
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Published in | Biomedicine & pharmacotherapy Vol. 130; p. 110574 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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01.10.2020
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Abstract | [Display omitted]
•Holistic and integrated strategy to investigate the compatibility of TCM herbal pair.•NS and SF showed different effect on ameliorating MI-related metabolic alterations.•NS showed greater effect on reversing proinflammatory signals than SF.•SF exhibited better effect on decreasing oxidative stress than NS.•NS and SF interact to produce an enhanced anti-MI efficacy than their individual use.
The Notoginseng–Safflower pair composed of Panax notoginseng (Burk.) F. H. Chen and Carthamus tinctorius L. has remarkable clinical efficacy for preventing and treating cardiovascular diseases in China. Notoginseng total saponins (NS) and Safflower total flavonoids (SF) are the major effective ingredients in Notoginseng and Safflower, respectively. Though our previous study showed that the combination of NS and SF (NS–SF) exhibits significant cardioprotective effects for myocardial ischemia (MI), there might be difference in their action mechanisms. However, the anti-MI characteristics of individual NS and SF remains unclear. Herein, an integrated metabolomics strategy coupled with multiple biological methods were employed to investigate the cardioprotective effects of NS and SF alone or in combination against isoproterenol (ISO)-induced MI and to further explore the synergistic relationship between NS and SF. Our results demonstrated that pretreatments with NS, SF, and NS–SF all showed cardioprotective effects against MI injury and NS–SF exhibited to be the best. Interestingly, the results demonstrated that NS and SF exhibited differentiated metabolic targets and mediators in the glycerophospholipid metabolism. Furthermore, administration of NS alone exhibited greater effects on reversing the elevated the proinflammatory metabolites and mediators in MI rats compared to SF alone. However, individual SF showed greater amelioration of MI-disturbed antioxidant and prooxidative metabolites and better inhibition of the oxidative stress than NS alone. Collectively, our study demonstrated that the capability of NS–SF to regulate both metabolic targets of NS and SF might be the basis of NS–SF to produce a cooperative effect greater than their individual effects that enhance the anti-MI efficacy and provided valuable information for the clinical application of Notoginseng–Safflower pair. |
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AbstractList | The Notoginseng-Safflower pair composed of Panax notoginseng (Burk.) F. H. Chen and Carthamus tinctorius L. has remarkable clinical efficacy for preventing and treating cardiovascular diseases in China. Notoginseng total saponins (NS) and Safflower total flavonoids (SF) are the major effective ingredients in Notoginseng and Safflower, respectively. Though our previous study showed that the combination of NS and SF (NS-SF) exhibits significant cardioprotective effects for myocardial ischemia (MI), there might be difference in their action mechanisms. However, the anti-MI characteristics of individual NS and SF remains unclear. Herein, an integrated metabolomics strategy coupled with multiple biological methods were employed to investigate the cardioprotective effects of NS and SF alone or in combination against isoproterenol (ISO)-induced MI and to further explore the synergistic relationship between NS and SF. Our results demonstrated that pretreatments with NS, SF, and NS-SF all showed cardioprotective effects against MI injury and NS-SF exhibited to be the best. Interestingly, the results demonstrated that NS and SF exhibited differentiated metabolic targets and mediators in the glycerophospholipid metabolism. Furthermore, administration of NS alone exhibited greater effects on reversing the elevated the proinflammatory metabolites and mediators in MI rats compared to SF alone. However, individual SF showed greater amelioration of MI-disturbed antioxidant and prooxidative metabolites and better inhibition of the oxidative stress than NS alone. Collectively, our study demonstrated that the capability of NS-SF to regulate both metabolic targets of NS and SF might be the basis of NS-SF to produce a cooperative effect greater than their individual effects that enhance the anti-MI efficacy and provided valuable information for the clinical application of Notoginseng-Safflower pair. [Display omitted] •Holistic and integrated strategy to investigate the compatibility of TCM herbal pair.•NS and SF showed different effect on ameliorating MI-related metabolic alterations.•NS showed greater effect on reversing proinflammatory signals than SF.•SF exhibited better effect on decreasing oxidative stress than NS.•NS and SF interact to produce an enhanced anti-MI efficacy than their individual use. The Notoginseng–Safflower pair composed of Panax notoginseng (Burk.) F. H. Chen and Carthamus tinctorius L. has remarkable clinical efficacy for preventing and treating cardiovascular diseases in China. Notoginseng total saponins (NS) and Safflower total flavonoids (SF) are the major effective ingredients in Notoginseng and Safflower, respectively. Though our previous study showed that the combination of NS and SF (NS–SF) exhibits significant cardioprotective effects for myocardial ischemia (MI), there might be difference in their action mechanisms. However, the anti-MI characteristics of individual NS and SF remains unclear. Herein, an integrated metabolomics strategy coupled with multiple biological methods were employed to investigate the cardioprotective effects of NS and SF alone or in combination against isoproterenol (ISO)-induced MI and to further explore the synergistic relationship between NS and SF. Our results demonstrated that pretreatments with NS, SF, and NS–SF all showed cardioprotective effects against MI injury and NS–SF exhibited to be the best. Interestingly, the results demonstrated that NS and SF exhibited differentiated metabolic targets and mediators in the glycerophospholipid metabolism. Furthermore, administration of NS alone exhibited greater effects on reversing the elevated the proinflammatory metabolites and mediators in MI rats compared to SF alone. However, individual SF showed greater amelioration of MI-disturbed antioxidant and prooxidative metabolites and better inhibition of the oxidative stress than NS alone. Collectively, our study demonstrated that the capability of NS–SF to regulate both metabolic targets of NS and SF might be the basis of NS–SF to produce a cooperative effect greater than their individual effects that enhance the anti-MI efficacy and provided valuable information for the clinical application of Notoginseng–Safflower pair. |
ArticleNumber | 110574 |
Author | Jiang, Yong Meng, Yuqing Guo, Xiaoyu Du, Zhiyong Li, Yan Gao, Peng Tu, Pengfei Song, Jinyang Lu, Yingyuan |
Author_xml | – sequence: 1 givenname: Yuqing surname: Meng fullname: Meng, Yuqing – sequence: 2 givenname: Zhiyong surname: Du fullname: Du, Zhiyong – sequence: 3 givenname: Yan surname: Li fullname: Li, Yan – sequence: 4 givenname: Peng surname: Gao fullname: Gao, Peng – sequence: 5 givenname: Jinyang surname: Song fullname: Song, Jinyang – sequence: 6 givenname: Yingyuan surname: Lu fullname: Lu, Yingyuan – sequence: 7 givenname: Pengfei surname: Tu fullname: Tu, Pengfei – sequence: 8 givenname: Yong surname: Jiang fullname: Jiang, Yong email: yongjiang@bjmu.edu.cn – sequence: 9 givenname: Xiaoyu surname: Guo fullname: Guo, Xiaoyu email: guoxiaoyu@bjmu.edu.cn |
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Cites_doi | 10.1016/j.yjmcc.2014.10.002 10.1016/j.jep.2012.11.036 10.1016/j.jep.2016.01.022 10.1016/j.freeradbiomed.2011.05.004 10.1016/j.phrs.2020.104654 10.1038/nrd.2016.32 10.1016/j.jacc.2011.09.083 10.1016/j.biopha.2019.109268 10.1016/j.cjca.2016.12.013 10.1016/j.cardfail.2014.11.006 10.1016/j.ijcard.2012.04.150 10.1016/j.ijbiomac.2020.01.068 10.1016/j.phrs.2019.104488 10.1016/j.freeradbiomed.2008.04.029 10.1016/j.ejphar.2019.172587 10.1038/nrcardio.2011.138 10.1016/j.atherosclerosis.2018.07.025 10.1016/j.jpba.2019.112936 10.1038/nrcardio.2014.177-c1 10.1038/nprot.2016.156 10.1016/j.jep.2019.02.035 10.1001/jamacardio.2019.0295 10.1016/j.drudis.2015.04.009 10.3390/pharmaceutics12020180 10.1016/j.jacc.2016.11.078 10.1016/j.intimp.2020.106316 10.1536/ihj.16-414 10.1016/j.jep.2012.07.033 10.3389/fphar.2018.00667 10.1053/meta.2003.50049 10.1016/j.trac.2014.06.007 10.1016/j.jpba.2019.112807 10.1016/j.jgr.2014.03.001 10.1016/j.redox.2014.05.006 10.1016/j.phrs.2020.104627 10.1002/mnfr.201500031 10.1016/j.cellimm.2010.08.003 10.1016/j.jgr.2017.10.004 10.1007/s11010-016-2843-6 10.1016/j.jacc.2019.04.036 10.1161/CIRCULATIONAHA.115.020226 |
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Keywords | DHE Metabolomics NS CK-MB LCAT Myocardial ischemia MDA AUC LDH NF-κB Synergistic effects SF ANOVA Notoginseng total saponins cTnT FAs ESI MI UPLC–QTOF-MS AA 20-HETE GSH-Px IL Safflower total flavonoids ISO H&E LC–MS OPLS-DA ROC ECG PLA2 SOD PCA TIC LysoPE PA BCAAs LysoPC PC TNF-α LA ROS XO SEM VIP CVDs ELISA TCM |
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References | Han, Li, Ma, Zhang, Ma, Jiang, Tu (bib0045) 2013; 145 Gebhard, Rhainds, He, Rodes-Cabau, Lavi, Spence, Title, Kouz, L’Allier, Gregoire, Ibrahim, Cossette, Guertin, Beanlands, Rheaume, Tardif (bib0130) 2018; 276 Sugamura, Keaney (bib0175) 2011; 51 Le, Lin, Song, Wang, Hong (bib0035) 2019; 176 Southam, Weber, Engel, Jones, Viant (bib0080) 2016; 12 Schilling, Eder (bib0165) 2010; 265 Bodi, Sanchis, Morales, Marrachelli, Nunez, Forteza, Chaustre, Gomez, Mainar, Minana, Rumiz, Husser, Noguera, Diaz, Moratal, Carratala, Bosch, Llacer, Chorro, Vina, Monleon (bib0095) 2012; 59 Du X., A. Patel, C.S. Anderson, J. Dong, C. Ma, Epidemiology of cardiovascular disease in China and opportunities for improvement: JACC International, J. Am. Coll. Cardiol. 73 (2019) 3135−3147. https://doi:10.1016/j.jacc.2019.04.036. S. Liu, Y. Li, X. Zeng, H. Wang, P. Yin, L. Wang, Y. Liu, J. Liu, J. Qi, S. Ran, S. Yang, M. Zhou, Burden of cardiovascular diseases in China, 1990-2016: Findings from the 2016 global burden of disease study, JAMA Cardiol. 4 (2019) 342−352. https://doi:10.1001/jamacardio.2019.0295. Orgah, He, Wang, Jiang, Wang, Orgah, Duan, Zhao, Zhang, Han, Zhu (bib0030) 2020; 153 Wishart (bib0085) 2016; 15 Perez-Chacon, Astudillo, Balgoma, Balboa, Balsinde (bib0135) 2009; 1791 Li, Zhou, Li, Sun, Lv, Xu (bib0120) 2015; 20 Chen, Guo, Lu, Shi, Mu, Qian, Wang, Lu, Zhao, Tu, Song, Jiang (bib0075) 2020; 12 Guo, Luo, Liu, Liu, Wang, Lu (bib0100) 2020; 152 Schonfeld, Wojtczak (bib0170) 2008; 45 Lopaschuk (bib0205) 2017; 33 Sun, Olson, Gao, Prosdocimo, Zhou, Wang, Jeyaraj, Youn, Ren, Liu, Rau, Shah, Ilkayeva, Gui, William, Wynn, Newgard, Cai, Xiao, Chuang, Schulze, Lynch, Jain, Wang (bib0195) 2016; 133 Sonoki, Iwase, Iino, Ichikawa, Ohdo, Higuchi, Yoshinari, Iida (bib0145) 2003; 52 Yang, Cheung, Zhou, Xie, Cheng, Wu, Zhou, Tang, Hoi, Wang, Lee (bib0060) 2016; 181 Wang, Wang, Bai, Gao, Wang, Quan, Wang, Wang, Wang, Xie (bib0015) 2019; 118 Fan, Zhang, Xiao, Liu, Zhang, Yao, Chen (bib0020) 2020; 147 Meng, Du, Li, Wang, Gao, Gao, Li, Zhao, Jiang, Tu, Guo (bib0050) 2018; 9 Griffin, Atherton, Shockcor, Atzori (bib0125) 2011; 8 Yin, Ren, Yang, Duan, Huang, Fang, Li, Li, Yin, Hou, Kim, Wu (bib0180) 2016; 60 Yamashita, Emoto, Sasaki, Hirata (bib0210) 2016; 57 Xiong (bib0115) 2015; 12 Kim (bib0150) 2018; 42 Ye, Wang, Wang, Liu, Qi, Fu, Zhang, Zhang, Sun (bib0190) 2020; 82 Xu, Wang, Wang, Zhang, Cui, Pu, Li (bib0065) 2019; 236 Lu, Zhang, Hu, Zhang, Wang, Qian, Yang, Yang, Jiang, Guo (bib0070) 2019; 58 Lee, Kim (bib0155) 2014; 38 Song, Chen, Lu, Chang, Zhao, Tu, Jiang, Guo (bib0055) 2020; 178 Hu, Xu (bib0090) 2014; 61 Liperoti, Vetrano, Bernabei, Onder (bib0110) 2017; 69 Wang, Hu, Tan, Wu, Chen, Cao, Chen, Wang (bib0040) 2012; 143 Dos, Da, Azambuja, Ramos, Oliveira, Da, Pedra, Galdino, Do, Soares, Tavares, Spanevello, Stefanello, Braganhol (bib0185) 2017; 424 Zhang, Zhou, Sun, Yan, Han, Wang, Wang, Wei, Xu (bib0200) 2019; 861 Zeng, Zhong, Zhao, Kanchana, Zhang, Khan, Chakrabarti, Wu, Wang, Liang (bib0140) 2015; 79 Ueland, Svardal, Oie, Askevold, Nymoen, Bjorndal, Dahl, Gullestad, Berge, Aukrust (bib0105) 2013; 167 Wu, Li, Zhao, Ming, Zheng, Li, Lei, Chen (bib0025) 2020; 151 Tang, Wang, Shrestha, Borowski, Wu, Troughton, Klein, Hazen (bib0215) 2015; 21 Kalogeris, Bao, Korthuis (bib0160) 2014; 2 Orgah (10.1016/j.biopha.2020.110574_bib0030) 2020; 153 Ye (10.1016/j.biopha.2020.110574_bib0190) 2020; 82 Guo (10.1016/j.biopha.2020.110574_bib0100) 2020; 152 Han (10.1016/j.biopha.2020.110574_bib0045) 2013; 145 Li (10.1016/j.biopha.2020.110574_bib0120) 2015; 20 Gebhard (10.1016/j.biopha.2020.110574_bib0130) 2018; 276 Lopaschuk (10.1016/j.biopha.2020.110574_bib0205) 2017; 33 Liperoti (10.1016/j.biopha.2020.110574_bib0110) 2017; 69 Wu (10.1016/j.biopha.2020.110574_bib0025) 2020; 151 Song (10.1016/j.biopha.2020.110574_bib0055) 2020; 178 Le (10.1016/j.biopha.2020.110574_bib0035) 2019; 176 Sugamura (10.1016/j.biopha.2020.110574_bib0175) 2011; 51 Sun (10.1016/j.biopha.2020.110574_bib0195) 2016; 133 Fan (10.1016/j.biopha.2020.110574_bib0020) 2020; 147 Wishart (10.1016/j.biopha.2020.110574_bib0085) 2016; 15 10.1016/j.biopha.2020.110574_bib0005 Tang (10.1016/j.biopha.2020.110574_bib0215) 2015; 21 Sonoki (10.1016/j.biopha.2020.110574_bib0145) 2003; 52 Kim (10.1016/j.biopha.2020.110574_bib0150) 2018; 42 Wang (10.1016/j.biopha.2020.110574_bib0015) 2019; 118 Ueland (10.1016/j.biopha.2020.110574_bib0105) 2013; 167 Griffin (10.1016/j.biopha.2020.110574_bib0125) 2011; 8 Meng (10.1016/j.biopha.2020.110574_bib0050) 2018; 9 Kalogeris (10.1016/j.biopha.2020.110574_bib0160) 2014; 2 Wang (10.1016/j.biopha.2020.110574_bib0040) 2012; 143 Yang (10.1016/j.biopha.2020.110574_bib0060) 2016; 181 Zhang (10.1016/j.biopha.2020.110574_bib0200) 2019; 861 Southam (10.1016/j.biopha.2020.110574_bib0080) 2016; 12 Chen (10.1016/j.biopha.2020.110574_bib0075) 2020; 12 Xu (10.1016/j.biopha.2020.110574_bib0065) 2019; 236 Schilling (10.1016/j.biopha.2020.110574_bib0165) 2010; 265 Yin (10.1016/j.biopha.2020.110574_bib0180) 2016; 60 Lee (10.1016/j.biopha.2020.110574_bib0155) 2014; 38 Zeng (10.1016/j.biopha.2020.110574_bib0140) 2015; 79 Bodi (10.1016/j.biopha.2020.110574_bib0095) 2012; 59 Hu (10.1016/j.biopha.2020.110574_bib0090) 2014; 61 Yamashita (10.1016/j.biopha.2020.110574_bib0210) 2016; 57 Lu (10.1016/j.biopha.2020.110574_bib0070) 2019; 58 Xiong (10.1016/j.biopha.2020.110574_bib0115) 2015; 12 10.1016/j.biopha.2020.110574_bib0010 Perez-Chacon (10.1016/j.biopha.2020.110574_bib0135) 2009; 1791 Dos (10.1016/j.biopha.2020.110574_bib0185) 2017; 424 Schonfeld (10.1016/j.biopha.2020.110574_bib0170) 2008; 45 |
References_xml | – volume: 147 start-page: 233 year: 2020 end-page: 240 ident: bib0020 article-title: Cardioprotective effect of the polysaccharide from Ophiopogon japonicus on isoproterenol-induced myocardial ischemia in rats publication-title: Int. J. Biol. Macromol. contributor: fullname: Chen – volume: 133 start-page: 2038 year: 2016 end-page: 2049 ident: bib0195 article-title: Catabolic defect of branched-chain amino acids promotes heart failure publication-title: Circulation contributor: fullname: Wang – volume: 145 start-page: 722 year: 2013 end-page: 727 ident: bib0045 article-title: Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of publication-title: J. Ethnopharmacol. contributor: fullname: Tu – volume: 20 start-page: 1074 year: 2015 end-page: 1086 ident: bib0120 article-title: Herbal drugs against cardiovascular disease: traditional medicine and modern development publication-title: Drug Discov. Today contributor: fullname: Xu – volume: 143 start-page: 412 year: 2012 end-page: 423 ident: bib0040 article-title: Compatibility art of traditional Chinese medicine: from the perspective of herb pairs publication-title: J. Ethnopharmacol. contributor: fullname: Wang – volume: 9 start-page: 667 year: 2018 ident: bib0050 article-title: Integration of metabolomics with pharmacodynamics to elucidate the anti-myocardial ischemia effects of combination of notoginseng total saponins and safflower total flavonoids publication-title: Front. Pharmacol. contributor: fullname: Guo – volume: 59 start-page: 1629 year: 2012 end-page: 1641 ident: bib0095 article-title: Metabolomic profile of human myocardial ischemia by nuclear magnetic resonance spectroscopy of peripheral blood serum: a translational study based on transient coronary occlusion models publication-title: J. Am. Coll. Cardiol. contributor: fullname: Monleon – volume: 151 start-page: 104488 year: 2020 ident: bib0025 article-title: Effects and mechanisms of traditional Chinese herbal medicine in the treatment of ischemic cardiomyopathy publication-title: Pharmacol. Res. contributor: fullname: Chen – volume: 58 year: 2019 ident: bib0070 article-title: Application of multiple chemical and biological approaches for quality assessment of publication-title: Phytomedicine contributor: fullname: Guo – volume: 181 start-page: 50 year: 2016 end-page: 58 ident: bib0060 article-title: Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis publication-title: J. Ethnopharmacol. contributor: fullname: Lee – volume: 1791 year: 2009 ident: bib0135 article-title: Control of free arachidonic acid levels by phospholipases A publication-title: Biochim. Biophys. Acta contributor: fullname: Balsinde – volume: 33 start-page: 838 year: 2017 end-page: 849 ident: bib0205 article-title: Metabolic modulators in heart disease: past, present, and future publication-title: Can. J. Cardiol. contributor: fullname: Lopaschuk – volume: 42 start-page: 264 year: 2018 end-page: 269 ident: bib0150 article-title: Pharmacological and medical applications of publication-title: J. Ginseng Res. contributor: fullname: Kim – volume: 60 start-page: 134 year: 2016 end-page: 146 ident: bib0180 article-title: L-Cysteine metabolism and its nutritional implications publication-title: Mol. Nutr. Food Res. contributor: fullname: Wu – volume: 45 start-page: 231 year: 2008 end-page: 241 ident: bib0170 article-title: Fatty acids as modulators of the cellular production of reactive oxygen species publication-title: Free Radic. Biol. Med. contributor: fullname: Wojtczak – volume: 424 start-page: 69 year: 2017 end-page: 78 ident: bib0185 article-title: Methionine and methionine sulfoxide treatment induces M1/classical macrophage polarization and modulates oxidative stress and purinergic signaling parameters publication-title: Mol. Cell. Biochem. contributor: fullname: Braganhol – volume: 21 start-page: 91 year: 2015 end-page: 96 ident: bib0215 article-title: Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure publication-title: J. Card. Fail. contributor: fullname: Hazen – volume: 236 start-page: 443 year: 2019 end-page: 465 ident: bib0065 article-title: Analytical methods and biological activities of Panax notoginseng saponins: recent trends publication-title: J. Ethnopharmacol. contributor: fullname: Li – volume: 82 year: 2020 ident: bib0190 article-title: Hydroxysafflor yellow A inhibits hypoxia/reoxygenation-induced cardiomyocyte injury via regulating the AMPK/NLRP3 inflammasome pathway publication-title: Int. Immunopharmacol. contributor: fullname: Sun – volume: 2 start-page: 702 year: 2014 end-page: 714 ident: bib0160 article-title: Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioning publication-title: Redox Biol. contributor: fullname: Korthuis – volume: 265 start-page: 87 year: 2010 end-page: 90 ident: bib0165 article-title: Importance of lipid rafts for lysophosphatidylcholine-induced caspase-1 activation and reactive oxygen species generation publication-title: Cell. Immunol. contributor: fullname: Eder – volume: 861 year: 2019 ident: bib0200 article-title: Beneficial effects of Oridonin on myocardial ischemia/reperfusion injury: insight gained by metabolomic approaches publication-title: Eur. J. Pharmacol. contributor: fullname: Xu – volume: 38 start-page: 161 year: 2014 end-page: 166 ident: bib0155 article-title: A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases publication-title: J. Ginseng Res. contributor: fullname: Kim – volume: 57 start-page: 663 year: 2016 end-page: 671 ident: bib0210 article-title: Gut microbiota and coronary artery disease publication-title: Int. Heart J. contributor: fullname: Hirata – volume: 61 start-page: 207 year: 2014 end-page: 214 ident: bib0090 article-title: Metabolomics and traditional Chinese medicine publication-title: TrAC Trend. Anal. Chem. contributor: fullname: Xu – volume: 51 start-page: 978 year: 2011 end-page: 992 ident: bib0175 article-title: Reactive oxygen species in cardiovascular disease publication-title: Free Radic. Biol. Med. contributor: fullname: Keaney – volume: 118 start-page: 109268 year: 2019 ident: bib0015 article-title: Investigating the effects and possible mechanisms of danshen-honghua herb pair on acute myocardial ischemia induced by isoproterenol in rats publication-title: Biomed. Pharmacother. contributor: fullname: Xie – volume: 12 start-page: 310 year: 2016 end-page: 328 ident: bib0080 article-title: A complete workflow for high-resolution spectral-stitching nanoelectrospray direct-infusion mass-spectrometry-based metabolomics and lipidomics publication-title: Nat. Protoc. contributor: fullname: Viant – volume: 152 year: 2020 ident: bib0100 article-title: Omics strategies decipher therapeutic discoveries of traditional Chinese medicine against different diseases at multiple layers molecular-level publication-title: Pharmacol. Res. contributor: fullname: Lu – volume: 79 start-page: 1 year: 2015 end-page: 12 ident: bib0140 article-title: Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-kappa B both in vitro and in vivo publication-title: J. Mol. Cell. Cardiol. contributor: fullname: Liang – volume: 167 start-page: 1892 year: 2013 end-page: 1899 ident: bib0105 article-title: Disturbed carnitine regulation in chronic heart failure--increased plasma levels of palmitoyl-carnitine are associated with poor prognosis publication-title: Int. J. Cardiol. contributor: fullname: Aukrust – volume: 12 start-page: 374 year: 2015 ident: bib0115 article-title: Integrating traditional Chinese medicine into Western cardiovascular medicine: an evidence-based approach publication-title: Nat. Rev. Cardiol. contributor: fullname: Xiong – volume: 69 start-page: 1188 year: 2017 end-page: 1199 ident: bib0110 article-title: Herbal medications in cardiovascular medicine publication-title: J. Am. Coll. Cardiol. contributor: fullname: Onder – volume: 8 start-page: 630 year: 2011 end-page: 643 ident: bib0125 article-title: Metabolomics as a tool for cardiac research publication-title: Nat. Rev. Cardiol. contributor: fullname: Atzori – volume: 15 start-page: 473 year: 2016 end-page: 484 ident: bib0085 article-title: Emerging applications of metabolomics in drug discovery and precision medicine publication-title: Nat. Rev. Drug Discov. contributor: fullname: Wishart – volume: 12 year: 2020 ident: bib0075 article-title: Large volume direct injection ultra-high performance liquid chromatography-tandem mass spectrometry-based comparative pharmacokinetic study between single and combinatory uses of Carthamus tinctorius extract and Notoginseng total saponins publication-title: Pharmaceutics. contributor: fullname: Jiang – volume: 153 year: 2020 ident: bib0030 article-title: Pharmacological potential of the combination of Salvia miltiorrhiza (Danshen) and Carthamus tinctorius (Honghua) for diabetes mellitus and its cardiovascular complications publication-title: Pharmacol. Res. contributor: fullname: Zhu – volume: 178 year: 2020 ident: bib0055 article-title: Comparative study on metabolic profiling and excretion in rat bile between combination of notoginseng total saponins and safflower total flavonoids and its individual extracts by LC-MS/MS publication-title: J. Pharm. Biomed. Anal. contributor: fullname: Guo – volume: 176 year: 2019 ident: bib0035 article-title: LC-MS/MS combined with publication-title: J. Pharm. Biomed. Anal. contributor: fullname: Hong – volume: 276 start-page: 131 year: 2018 end-page: 139 ident: bib0130 article-title: Elevated level of lecithin: cholesterol acyltransferase (LCAT) is associated with reduced coronary atheroma burden publication-title: Atherosclerosis contributor: fullname: Tardif – volume: 52 start-page: 308 year: 2003 end-page: 314 ident: bib0145 article-title: Atherogenic role of lysophosphatidylcholine in low-density lipoprotein modified by phospholipase A2 and in diabetic patients: protection by nitric oxide donor publication-title: Metabolism contributor: fullname: Iida – volume: 1791 year: 2009 ident: 10.1016/j.biopha.2020.110574_bib0135 article-title: Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases publication-title: Biochim. Biophys. Acta contributor: fullname: Perez-Chacon – volume: 79 start-page: 1 year: 2015 ident: 10.1016/j.biopha.2020.110574_bib0140 article-title: Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-kappa B both in vitro and in vivo publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2014.10.002 contributor: fullname: Zeng – volume: 145 start-page: 722 year: 2013 ident: 10.1016/j.biopha.2020.110574_bib0045 article-title: Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2012.11.036 contributor: fullname: Han – volume: 181 start-page: 50 year: 2016 ident: 10.1016/j.biopha.2020.110574_bib0060 article-title: Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2016.01.022 contributor: fullname: Yang – volume: 51 start-page: 978 year: 2011 ident: 10.1016/j.biopha.2020.110574_bib0175 article-title: Reactive oxygen species in cardiovascular disease publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2011.05.004 contributor: fullname: Sugamura – volume: 153 year: 2020 ident: 10.1016/j.biopha.2020.110574_bib0030 article-title: Pharmacological potential of the combination of Salvia miltiorrhiza (Danshen) and Carthamus tinctorius (Honghua) for diabetes mellitus and its cardiovascular complications publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2020.104654 contributor: fullname: Orgah – volume: 15 start-page: 473 year: 2016 ident: 10.1016/j.biopha.2020.110574_bib0085 article-title: Emerging applications of metabolomics in drug discovery and precision medicine publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd.2016.32 contributor: fullname: Wishart – volume: 59 start-page: 1629 year: 2012 ident: 10.1016/j.biopha.2020.110574_bib0095 article-title: Metabolomic profile of human myocardial ischemia by nuclear magnetic resonance spectroscopy of peripheral blood serum: a translational study based on transient coronary occlusion models publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2011.09.083 contributor: fullname: Bodi – volume: 118 start-page: 109268 year: 2019 ident: 10.1016/j.biopha.2020.110574_bib0015 article-title: Investigating the effects and possible mechanisms of danshen-honghua herb pair on acute myocardial ischemia induced by isoproterenol in rats publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2019.109268 contributor: fullname: Wang – volume: 33 start-page: 838 year: 2017 ident: 10.1016/j.biopha.2020.110574_bib0205 article-title: Metabolic modulators in heart disease: past, present, and future publication-title: Can. J. Cardiol. doi: 10.1016/j.cjca.2016.12.013 contributor: fullname: Lopaschuk – volume: 21 start-page: 91 year: 2015 ident: 10.1016/j.biopha.2020.110574_bib0215 article-title: Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure publication-title: J. Card. Fail. doi: 10.1016/j.cardfail.2014.11.006 contributor: fullname: Tang – volume: 167 start-page: 1892 year: 2013 ident: 10.1016/j.biopha.2020.110574_bib0105 article-title: Disturbed carnitine regulation in chronic heart failure--increased plasma levels of palmitoyl-carnitine are associated with poor prognosis publication-title: Int. J. Cardiol. doi: 10.1016/j.ijcard.2012.04.150 contributor: fullname: Ueland – volume: 147 start-page: 233 year: 2020 ident: 10.1016/j.biopha.2020.110574_bib0020 article-title: Cardioprotective effect of the polysaccharide from Ophiopogon japonicus on isoproterenol-induced myocardial ischemia in rats publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2020.01.068 contributor: fullname: Fan – volume: 151 start-page: 104488 year: 2020 ident: 10.1016/j.biopha.2020.110574_bib0025 article-title: Effects and mechanisms of traditional Chinese herbal medicine in the treatment of ischemic cardiomyopathy publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2019.104488 contributor: fullname: Wu – volume: 45 start-page: 231 year: 2008 ident: 10.1016/j.biopha.2020.110574_bib0170 article-title: Fatty acids as modulators of the cellular production of reactive oxygen species publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2008.04.029 contributor: fullname: Schonfeld – volume: 861 year: 2019 ident: 10.1016/j.biopha.2020.110574_bib0200 article-title: Beneficial effects of Oridonin on myocardial ischemia/reperfusion injury: insight gained by metabolomic approaches publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2019.172587 contributor: fullname: Zhang – volume: 8 start-page: 630 year: 2011 ident: 10.1016/j.biopha.2020.110574_bib0125 article-title: Metabolomics as a tool for cardiac research publication-title: Nat. Rev. Cardiol. doi: 10.1038/nrcardio.2011.138 contributor: fullname: Griffin – volume: 276 start-page: 131 year: 2018 ident: 10.1016/j.biopha.2020.110574_bib0130 article-title: Elevated level of lecithin: cholesterol acyltransferase (LCAT) is associated with reduced coronary atheroma burden publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2018.07.025 contributor: fullname: Gebhard – volume: 178 year: 2020 ident: 10.1016/j.biopha.2020.110574_bib0055 article-title: Comparative study on metabolic profiling and excretion in rat bile between combination of notoginseng total saponins and safflower total flavonoids and its individual extracts by LC-MS/MS publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2019.112936 contributor: fullname: Song – volume: 12 start-page: 374 year: 2015 ident: 10.1016/j.biopha.2020.110574_bib0115 article-title: Integrating traditional Chinese medicine into Western cardiovascular medicine: an evidence-based approach publication-title: Nat. Rev. Cardiol. doi: 10.1038/nrcardio.2014.177-c1 contributor: fullname: Xiong – volume: 12 start-page: 310 year: 2016 ident: 10.1016/j.biopha.2020.110574_bib0080 article-title: A complete workflow for high-resolution spectral-stitching nanoelectrospray direct-infusion mass-spectrometry-based metabolomics and lipidomics publication-title: Nat. Protoc. doi: 10.1038/nprot.2016.156 contributor: fullname: Southam – volume: 236 start-page: 443 year: 2019 ident: 10.1016/j.biopha.2020.110574_bib0065 article-title: Analytical methods and biological activities of Panax notoginseng saponins: recent trends publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2019.02.035 contributor: fullname: Xu – ident: 10.1016/j.biopha.2020.110574_bib0005 doi: 10.1001/jamacardio.2019.0295 – volume: 20 start-page: 1074 year: 2015 ident: 10.1016/j.biopha.2020.110574_bib0120 article-title: Herbal drugs against cardiovascular disease: traditional medicine and modern development publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2015.04.009 contributor: fullname: Li – volume: 12 year: 2020 ident: 10.1016/j.biopha.2020.110574_bib0075 article-title: Large volume direct injection ultra-high performance liquid chromatography-tandem mass spectrometry-based comparative pharmacokinetic study between single and combinatory uses of Carthamus tinctorius extract and Notoginseng total saponins publication-title: Pharmaceutics. doi: 10.3390/pharmaceutics12020180 contributor: fullname: Chen – volume: 69 start-page: 1188 year: 2017 ident: 10.1016/j.biopha.2020.110574_bib0110 article-title: Herbal medications in cardiovascular medicine publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2016.11.078 contributor: fullname: Liperoti – volume: 82 year: 2020 ident: 10.1016/j.biopha.2020.110574_bib0190 article-title: Hydroxysafflor yellow A inhibits hypoxia/reoxygenation-induced cardiomyocyte injury via regulating the AMPK/NLRP3 inflammasome pathway publication-title: Int. Immunopharmacol. doi: 10.1016/j.intimp.2020.106316 contributor: fullname: Ye – volume: 57 start-page: 663 year: 2016 ident: 10.1016/j.biopha.2020.110574_bib0210 article-title: Gut microbiota and coronary artery disease publication-title: Int. Heart J. doi: 10.1536/ihj.16-414 contributor: fullname: Yamashita – volume: 143 start-page: 412 year: 2012 ident: 10.1016/j.biopha.2020.110574_bib0040 article-title: Compatibility art of traditional Chinese medicine: from the perspective of herb pairs publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2012.07.033 contributor: fullname: Wang – volume: 9 start-page: 667 year: 2018 ident: 10.1016/j.biopha.2020.110574_bib0050 article-title: Integration of metabolomics with pharmacodynamics to elucidate the anti-myocardial ischemia effects of combination of notoginseng total saponins and safflower total flavonoids publication-title: Front. Pharmacol. doi: 10.3389/fphar.2018.00667 contributor: fullname: Meng – volume: 52 start-page: 308 year: 2003 ident: 10.1016/j.biopha.2020.110574_bib0145 article-title: Atherogenic role of lysophosphatidylcholine in low-density lipoprotein modified by phospholipase A2 and in diabetic patients: protection by nitric oxide donor publication-title: Metabolism doi: 10.1053/meta.2003.50049 contributor: fullname: Sonoki – volume: 61 start-page: 207 year: 2014 ident: 10.1016/j.biopha.2020.110574_bib0090 article-title: Metabolomics and traditional Chinese medicine publication-title: TrAC Trend. Anal. Chem. doi: 10.1016/j.trac.2014.06.007 contributor: fullname: Hu – volume: 176 year: 2019 ident: 10.1016/j.biopha.2020.110574_bib0035 article-title: LC-MS/MS combined with in vivomicrodialysis sampling from conscious rat striatum for simultaneous determination of active constituents of Yuanhu- Baizhi herb pair and endogenous neurotransmitters: Application to pharmacokinetic and pharmacodynamic study publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2019.112807 contributor: fullname: Le – volume: 38 start-page: 161 year: 2014 ident: 10.1016/j.biopha.2020.110574_bib0155 article-title: A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases publication-title: J. Ginseng Res. doi: 10.1016/j.jgr.2014.03.001 contributor: fullname: Lee – volume: 58 year: 2019 ident: 10.1016/j.biopha.2020.110574_bib0070 article-title: Application of multiple chemical and biological approaches for quality assessment of Carthamus tinctorius L. (safflower) by determining both the primary and secondary metabolites publication-title: Phytomedicine contributor: fullname: Lu – volume: 2 start-page: 702 year: 2014 ident: 10.1016/j.biopha.2020.110574_bib0160 article-title: Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioning publication-title: Redox Biol. doi: 10.1016/j.redox.2014.05.006 contributor: fullname: Kalogeris – volume: 152 year: 2020 ident: 10.1016/j.biopha.2020.110574_bib0100 article-title: Omics strategies decipher therapeutic discoveries of traditional Chinese medicine against different diseases at multiple layers molecular-level publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2020.104627 contributor: fullname: Guo – volume: 60 start-page: 134 year: 2016 ident: 10.1016/j.biopha.2020.110574_bib0180 article-title: L-Cysteine metabolism and its nutritional implications publication-title: Mol. Nutr. Food Res. doi: 10.1002/mnfr.201500031 contributor: fullname: Yin – volume: 265 start-page: 87 year: 2010 ident: 10.1016/j.biopha.2020.110574_bib0165 article-title: Importance of lipid rafts for lysophosphatidylcholine-induced caspase-1 activation and reactive oxygen species generation publication-title: Cell. Immunol. doi: 10.1016/j.cellimm.2010.08.003 contributor: fullname: Schilling – volume: 42 start-page: 264 year: 2018 ident: 10.1016/j.biopha.2020.110574_bib0150 article-title: Pharmacological and medical applications of Panax ginseng and ginsenosides: a review for use in cardiovascular diseases publication-title: J. Ginseng Res. doi: 10.1016/j.jgr.2017.10.004 contributor: fullname: Kim – volume: 424 start-page: 69 year: 2017 ident: 10.1016/j.biopha.2020.110574_bib0185 article-title: Methionine and methionine sulfoxide treatment induces M1/classical macrophage polarization and modulates oxidative stress and purinergic signaling parameters publication-title: Mol. Cell. Biochem. doi: 10.1007/s11010-016-2843-6 contributor: fullname: Dos – ident: 10.1016/j.biopha.2020.110574_bib0010 doi: 10.1016/j.jacc.2019.04.036 – volume: 133 start-page: 2038 year: 2016 ident: 10.1016/j.biopha.2020.110574_bib0195 article-title: Catabolic defect of branched-chain amino acids promotes heart failure publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.115.020226 contributor: fullname: Sun |
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•Holistic and integrated strategy to investigate the compatibility of TCM herbal pair.•NS and SF showed different effect on ameliorating... The Notoginseng-Safflower pair composed of Panax notoginseng (Burk.) F. H. Chen and Carthamus tinctorius L. has remarkable clinical efficacy for preventing and... The Notoginseng–Safflower pair composed of Panax notoginseng (Burk.) F. H. Chen and Carthamus tinctorius L. has remarkable clinical efficacy for preventing and... |
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SubjectTerms | Animals Carthamus tinctorius Drug Synergism Flavonoids - pharmacology Flavonoids - therapeutic use Heart - drug effects Heart - physiology Male Metabolomics Myocardial ischemia Myocardial Ischemia - drug therapy Myocardial Ischemia - metabolism Myocardial Ischemia - pathology Myocardial Ischemia - physiopathology Myocardium - metabolism Myocardium - pathology Notoginseng total saponins Panax notoginseng Rats, Sprague-Dawley Safflower total flavonoids Saponins - pharmacology Saponins - therapeutic use Synergistic effects |
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Title | The synergistic mechanism of total saponins and flavonoids in Notoginseng−Safflower pair against myocardial ischemia uncovered by an integrated metabolomics strategy |
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