CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide - Gurney, Mark; Stikvoort, Arwen; Nolan, Emma; Kirkham-McCarthy, Lucy; Khoruzhenko, Stanislav; Shivakumar, Rama; Zweegman, Sonja; Van de Donk, Niels W.C.J.; Mutis, Tuna; Szegezdi, Eva; Sarkar, Subhashis; O’Dwyer, Michael (Haematologica (Roma), 2022)
Keywords: ADP-ribosyl Cyclase 1; Cell Line, Tumor; Cytotoxicity, Immunologic; Gene Knockout Techniques; Humans; Immunotherapy, Adoptive; Killer Cells, Natural; Leukemia, Myeloid, Acute - therapy; Membrane Glycoproteins; Receptors, Chimeric Antigen - genetics