Targeting TRPV1 on cellular plasticity regulated by Ovol 2 and Zeb 1 in hepatocellular carcinoma

• Published in: Biomedicine & pharmacotherapy Vol. 118; p. 109270
• Main Authors: Xie, Chengzhi, Liu, Guoxing, Li, Min, Fang, Yu, Qian, Ke, Tang, Yu, Wu, Xiaolong, Lei, Xiaohua, Li, Xiaocheng, Liu, Qiang, Liu, Gao, Liu, Jiefeng, Zhang, Yueming, Huang, Zhao, Hu, Zecheng, Cao, Zhenyu, Hu, Jixiong, Huang, Shengfu, Zhong, Dewu, Huang, Jiangsheng, Wu, Fangxiang, Wang, Jun, Mori, Masaki, Yamamoto, Hirofumi, Wang, Jianxin, Xu, Xundi
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.10.2019; Elsevier
• Subjects: Animals; Capsaicin - pharmacology; Carcinogenesis - drug effects; Carcinogenesis - pathology; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - ultrastructure; Cell Line, Tumor; Cell Plasticity - drug effects; EMT; Epithelial-Mesenchymal Transition - drug effects; Female; Gene Expression Regulation, Neoplastic - drug effects; HCC; Hepatocarcinogenesis; Humans; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Liver Neoplasms - ultrastructure; Mice, Inbred C57BL; Mice, Knockout; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Ovol2; Transcription Factors - metabolism; TRPV Cation Channels - metabolism; TRPV1; Xenograft Model Antitumor Assays; Zeb1; Zinc Finger E-box-Binding Homeobox 1 - metabolism; AST; KO; H&E; HCC; ALT; DBI; TRPV1; AFP; DEN; ChIP; EMT; STR; Zeb1; DMEM; RSAT; TBA; hrEGF; Hepatocarcinogenesis; Zeb; TBIL; MET; WT; CHOL; Ovol2

[Display omitted] •TRPV1 shows targeting potential in hepatocellular carcinoma.•TRPV1 gives rise to phenotypic plasticity in hepatocarcinogenesis.•Tumor initiating cells and biliary cells were cellular origins in TRPV1 induced HCC.•TRPV 1 exert its role via transcription factors Ovol 2 and Zeb 1 med...