Relationship Between the Gut Microbiome, Tryptophan-Derived Metabolites, and Osteoarthritis-Related Pain: A Systematic Review with Meta-Analysis

• Published in: Nutrients Vol. 17; no. 2; p. 264
• Main Authors: Meléndez-Oliva, Erika, Martínez-Pozas, Oliver, Sinatti, Pierluigi, Martín Carreras-Presas, Carmen, Cuenca-Zaldívar, Juan Nicolás, Turroni, Silvia, Sánchez Romero, Eleuterio A.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2025; MDPI
• Subjects: Analysis; Brain research; Care and treatment; Chronic pain; Disease; Female; Gastrointestinal Microbiome - physiology; Gut microbiota; Humans; Inflammation; Intervention; Medical research; Medical Subject Headings-MeSH; Medicine, Experimental; Meta-analysis; Metabolism; Metabolites; Observational studies; Osteoarthritis; Osteoarthritis - complications; Osteoarthritis - metabolism; Osteoarthritis - microbiology; Pain; Pain - etiology; Pain - microbiology; Permeability; Serotonin; Systematic Review; Tryptophan; Tryptophan - metabolism; Tumor necrosis factor-TNF; Colombia; Spain; gut microbiome; inflammation; osteoarthritis; tryptophan; dysbiosis

Introduction: Osteoarthritis (OA) is the most prevalent form of arthritis and affects over 528 million people worldwide. Degenerative joint disease involves cartilage degradation, subchondral bone remodeling, and synovial inflammation, leading to chronic pain, stiffness, and impaired joint function....