The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs

• Published in: Molecular neurobiology Vol. 57; no. 7; pp. 2996 - 3013
• Main Authors: Wang, Wang-Xia, Prajapati, Paresh, Nelson, Peter T., Springer, Joe E.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2020; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Animals; Biomedical and Life Sciences; Biomedicine; Brain; Brain - metabolism; Cell Biology; Cellular stress response; Cognitive Dysfunction - metabolism; Cytosol; Cytosol - metabolism; Dementia - metabolism; Endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Female; Humans; Inflammation; Inflammation - metabolism; Intracellular Membranes - metabolism; Male; MicroRNAs; MicroRNAs - metabolism; miRNA; Mitochondria; Mitochondria - metabolism; Neurobiology; Neurodegenerative diseases; Neurology; Neurosciences; Organelles; Original; Original Article; Rats; Rats, Sprague-Dawley; Subcellular Fractions - metabolism; Traumatic brain injury; Mitochondria-associated ER membrane; microRNA; miR-146a; Traumatic brain injury; Subcellular; Neurodegeneration

The mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are specific ER domains that contact the mitochondria and function to facilitate communication between ER and mitochondria. Disruption of contact between the mitochondria and ER is associated with a variety of pathophysiological...