Inhibition of platelet-derived growth factor pathway suppresses tubulointerstitial injury in renal congestion

• Published in: Journal of hypertension Vol. 40; no. 10; p. 1935
• Main Authors: Matsuki, Takuma, Hirose, Takuo, Ohsaki, Yusuke, Shimada, Satoshi, Endo, Akari, Ito, Hiroki, Takahashi, Chika, Yamakoshi, Seiko, Oba-Yabana, Ikuko, Anan, Go, Kato, Toshiko, Tajima, Ryo, Nakayama, Shingo, Kimura, Tomoyoshi, Nakamura, Hannah, Tani, Junichi, Takahashi, Kazuhiro, Kure, Shigeo, Mori, Takefumi
• Format: Journal Article
• Language: English
• Published: England 01.10.2022
• Subjects: Animals; Fibrosis; Humans; Hyperemia; Imatinib Mesylate - metabolism; Imatinib Mesylate - pharmacology; Kidney - metabolism; Kidney Diseases - metabolism; Male; Platelet-Derived Growth Factor - metabolism; Platelet-Derived Growth Factor - pharmacology; Rats; Rats, Sprague-Dawley

Increased central venous pressure in congestive heart failure is responsible for renal dysfunction, which is mediated by renal venous congestion. Pericyte detachment from capillaries after renal congestion might trigger renal fibrogenesis via pericyte-myofibroblast transition (PMT). Platelet-derived...