The salivary microbiome is consistent between subjects and resistant to impacts of short-term hospitalization
In recent years, a growing amount of research has begun to focus on the oral microbiome due to its links with health and systemic disease. The oral microbiome has numerous advantages that make it particularly useful for clinical studies, including non-invasive collection, temporal stability, and low...
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| Published in | Scientific reports Vol. 7; no. 1; pp. 11040 - 13 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
08.09.2017
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | In recent years, a growing amount of research has begun to focus on the oral microbiome due to its links with health and systemic disease. The oral microbiome has numerous advantages that make it particularly useful for clinical studies, including non-invasive collection, temporal stability, and lower complexity relative to other niches, such as the gut. Despite recent discoveries made in this area, it is unknown how the oral microbiome responds to short-term hospitalization. Previous studies have demonstrated that the gut microbiome is extremely sensitive to short-term hospitalization and that these changes are associated with significant morbidity and mortality. Here, we present a comprehensive pipeline for reliable bedside collection, sequencing, and analysis of the human salivary microbiome. We also develop a novel oral-specific mock community for pipeline validation. Using our methodology, we analyzed the salivary microbiomes of patients before and during hospitalization or azithromycin treatment to profile impacts on this community. Our findings indicate that azithromycin alters the diversity and taxonomic composition of the salivary microbiome; however, we also found that short-term hospitalization does not impact the richness or structure of this community, suggesting that the oral cavity may be less susceptible to dysbiosis during short-term hospitalization. |
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| AbstractList | In recent years, a growing amount of research has begun to focus on the oral microbiome due to its links with health and systemic disease. The oral microbiome has numerous advantages that make it particularly useful for clinical studies, including non-invasive collection, temporal stability, and lower complexity relative to other niches, such as the gut. Despite recent discoveries made in this area, it is unknown how the oral microbiome responds to short-term hospitalization. Previous studies have demonstrated that the gut microbiome is extremely sensitive to short-term hospitalization and that these changes are associated with significant morbidity and mortality. Here, we present a comprehensive pipeline for reliable bedside collection, sequencing, and analysis of the human salivary microbiome. We also develop a novel oral-specific mock community for pipeline validation. Using our methodology, we analyzed the salivary microbiomes of patients before and during hospitalization or azithromycin treatment to profile impacts on this community. Our findings indicate that azithromycin alters the diversity and taxonomic composition of the salivary microbiome; however, we also found that short-term hospitalization does not impact the richness or structure of this community, suggesting that the oral cavity may be less susceptible to dysbiosis during short-term hospitalization. In recent years, a growing amount of research has begun to focus on the oral microbiome due to its links with health and systemic disease. The oral microbiome has numerous advantages that make it particularly useful for clinical studies, including non-invasive collection, temporal stability, and lower complexity relative to other niches, such as the gut. Despite recent discoveries made in this area, it is unknown how the oral microbiome responds to short-term hospitalization. Previous studies have demonstrated that the gut microbiome is extremely sensitive to short-term hospitalization and that these changes are associated with significant morbidity and mortality. Here, we present a comprehensive pipeline for reliable bedside collection, sequencing, and analysis of the human salivary microbiome. We also develop a novel oral-specific mock community for pipeline validation. Using our methodology, we analyzed the salivary microbiomes of patients before and during hospitalization or azithromycin treatment to profile impacts on this community. Our findings indicate that azithromycin alters the diversity and taxonomic composition of the salivary microbiome; however, we also found that short-term hospitalization does not impact the richness or structure of this community, suggesting that the oral cavity may be less susceptible to dysbiosis during short-term hospitalization.In recent years, a growing amount of research has begun to focus on the oral microbiome due to its links with health and systemic disease. The oral microbiome has numerous advantages that make it particularly useful for clinical studies, including non-invasive collection, temporal stability, and lower complexity relative to other niches, such as the gut. Despite recent discoveries made in this area, it is unknown how the oral microbiome responds to short-term hospitalization. Previous studies have demonstrated that the gut microbiome is extremely sensitive to short-term hospitalization and that these changes are associated with significant morbidity and mortality. Here, we present a comprehensive pipeline for reliable bedside collection, sequencing, and analysis of the human salivary microbiome. We also develop a novel oral-specific mock community for pipeline validation. Using our methodology, we analyzed the salivary microbiomes of patients before and during hospitalization or azithromycin treatment to profile impacts on this community. Our findings indicate that azithromycin alters the diversity and taxonomic composition of the salivary microbiome; however, we also found that short-term hospitalization does not impact the richness or structure of this community, suggesting that the oral cavity may be less susceptible to dysbiosis during short-term hospitalization. |
| ArticleNumber | 11040 |
| Author | Sano, William H. Wurster, Jenna I. Chan, Philip A. Korry, Benjamin J. Mylonakis, Eleftherios Fuchs, Beth Burgwyn Alevizakos, Michail Cabral, Damien J. Flokas, Myrto E. Rowan, Aislinn D. Zabat, Michelle Andreatos, Nikolaos Ducharme, R. Bobby Belenky, Peter |
| Author_xml | – sequence: 1 givenname: Damien J. surname: Cabral fullname: Cabral, Damien J. organization: Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University – sequence: 2 givenname: Jenna I. surname: Wurster fullname: Wurster, Jenna I. organization: Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University – sequence: 3 givenname: Myrto E. surname: Flokas fullname: Flokas, Myrto E. organization: Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School and Brown University – sequence: 4 givenname: Michail surname: Alevizakos fullname: Alevizakos, Michail organization: Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School and Brown University – sequence: 5 givenname: Michelle surname: Zabat fullname: Zabat, Michelle organization: Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University – sequence: 6 givenname: Benjamin J. surname: Korry fullname: Korry, Benjamin J. organization: Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University – sequence: 7 givenname: Aislinn D. surname: Rowan fullname: Rowan, Aislinn D. organization: Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University – sequence: 8 givenname: William H. surname: Sano fullname: Sano, William H. organization: Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University – sequence: 9 givenname: Nikolaos surname: Andreatos fullname: Andreatos, Nikolaos organization: Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School and Brown University – sequence: 10 givenname: R. Bobby surname: Ducharme fullname: Ducharme, R. Bobby organization: Department of Medicine, Brown University – sequence: 11 givenname: Philip A. surname: Chan fullname: Chan, Philip A. organization: Department of Medicine, Brown University – sequence: 12 givenname: Eleftherios surname: Mylonakis fullname: Mylonakis, Eleftherios organization: Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School and Brown University – sequence: 13 givenname: Beth Burgwyn surname: Fuchs fullname: Fuchs, Beth Burgwyn organization: Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School and Brown University – sequence: 14 givenname: Peter surname: Belenky fullname: Belenky, Peter email: Peter_Belenky@brown.edu organization: Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28887570$$D View this record in MEDLINE/PubMed |
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| Snippet | In recent years, a growing amount of research has begun to focus on the oral microbiome due to its links with health and systemic disease. The oral microbiome... |
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| SubjectTerms | 38/77 631/326/2565/107 631/326/2565/855 Azithromycin Dysbacteriosis Hospitalization Humanities and Social Sciences Intestinal microflora Morbidity multidisciplinary Niches Oral cavity Science Science (multidisciplinary) Short term |
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| Title | The salivary microbiome is consistent between subjects and resistant to impacts of short-term hospitalization |
| URI | https://link.springer.com/article/10.1038/s41598-017-11427-2 https://www.ncbi.nlm.nih.gov/pubmed/28887570 https://www.proquest.com/docview/1953983772 https://www.proquest.com/docview/1937530103 https://pubmed.ncbi.nlm.nih.gov/PMC5591268 |
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