HLA-C Genotyping Reveals Haplotype C07 as a Potential Biomarker of Late Psoriasis Onset in Moroccan Patients

• Published in: Current Issues in Molecular Biology Vol. 45; no. 2; pp. 1012 - 1023
• Main Authors: Benlabsir, Chaimaa, Riyad, Myriam, Saik, Imane El Idrissi, Ettayebi, Hanaa, Aazzane, Oussama, Nassar, Kawtar, Zaher, Soukaina, Bennani, Siham, Admou, Brahim, Housbane, Samy, Sadki, Khalid, Chiheb, Soumiya, Fellah, Hassan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.01.2023; MDPI
• Subjects: Analysis; Development and progression; Ethylenediaminetetraacetic acid; Genetic aspects; Health aspects; Histocompatibility antigens; HLA histocompatibility antigens; HLA-C allele; Medical research; Medicine, Experimental; methotrexate; Psoriasis; Morocco; methotrexate; psoriasis; HLA-C allele

Psoriasis still has an unknown etiology. Genetic predisposition shows the association between HLA-Cw6 allele and psoriasis. Although biotherapies have been proven effective in psoriasis treatment, methotrexate (MTX) is still used as a first-line systemic therapy due to its efficacy/affordability, bu...