HLA-C Genotyping Reveals Haplotype C07 as a Potential Biomarker of Late Psoriasis Onset in Moroccan Patients
Psoriasis still has an unknown etiology. Genetic predisposition shows the association between HLA-Cw6 allele and psoriasis. Although biotherapies have been proven effective in psoriasis treatment, methotrexate (MTX) is still used as a first-line systemic therapy due to its efficacy/affordability, bu...
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| Published in | Current Issues in Molecular Biology Vol. 45; no. 2; pp. 1012 - 1023 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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25.01.2023
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| Abstract | Psoriasis still has an unknown etiology. Genetic predisposition shows the association between HLA-Cw6 allele and psoriasis. Although biotherapies have been proven effective in psoriasis treatment, methotrexate (MTX) is still used as a first-line systemic therapy due to its efficacy/affordability, but the differential response to MTX is mostly related to interindividual genetic variability and remains an issue. Our study aimed to analyze HLA-C allele frequencies in a sample of Moroccan psoriatic patients and assess the therapeutic response to MTX. Whole blood of 54 Moroccan psoriatic patients was collected and DNA was extracted. Patients’ HLA-C locus was genotyped by PCR-SSO. Results were analyzed with Luminex xMAP Technology and Match-it DNA Evolution 3.4. HLA-C typing results of 77 sex- and age-matched unrelated non-psoriatic healthy subjects were included. We observed no difference in the allelic distribution of HLA-C between patients and healthy controls, suggesting that none of the HLA-C alleles were significantly associated with psoriasis. Moreover, the HLA-C*07 allele was associated with a late age at disease onset (>30 years old) (p = 0.007). No statistically significant association was found between HLA-C allele expression and response to MTX, despite a higher frequency of HLA-C*06 in responders compared to non-responders. Thus, HLA-C*07 could be a biomarker of late psoriasis onset in the Moroccan population. |
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| AbstractList | Psoriasis still has an unknown etiology. Genetic predisposition shows the association between HLA-Cw6 allele and psoriasis. Although biotherapies have been proven effective in psoriasis treatment, methotrexate (MTX) is still used as a first-line systemic therapy due to its efficacy/affordability, but the differential response to MTX is mostly related to interindividual genetic variability and remains an issue. Our study aimed to analyze HLA-C allele frequencies in a sample of Moroccan psoriatic patients and assess the therapeutic response to MTX. Whole blood of 54 Moroccan psoriatic patients was collected and DNA was extracted. Patients’ HLA-C locus was genotyped by PCR-SSO. Results were analyzed with Luminex xMAP Technology and Match-it DNA Evolution 3.4. HLA-C typing results of 77 sex- and age-matched unrelated non-psoriatic healthy subjects were included. We observed no difference in the allelic distribution of HLA-C between patients and healthy controls, suggesting that none of the HLA-C alleles were significantly associated with psoriasis. Moreover, the HLA-C*07 allele was associated with a late age at disease onset (>30 years old) (p = 0.007). No statistically significant association was found between HLA-C allele expression and response to MTX, despite a higher frequency of HLA-C*06 in responders compared to non-responders. Thus, HLA-C*07 could be a biomarker of late psoriasis onset in the Moroccan population. Psoriasis still has an unknown etiology. Genetic predisposition shows the association between HLA-Cw6 allele and psoriasis. Although biotherapies have been proven effective in psoriasis treatment, methotrexate (MTX) is still used as a first-line systemic therapy due to its efficacy/affordability, but the differential response to MTX is mostly related to interindividual genetic variability and remains an issue. Our study aimed to analyze HLA-C allele frequencies in a sample of Moroccan psoriatic patients and assess the therapeutic response to MTX. Whole blood of 54 Moroccan psoriatic patients was collected and DNA was extracted. Patients’ HLA-C locus was genotyped by PCR-SSO. Results were analyzed with Luminex xMAP Technology and Match-it DNA Evolution 3.4. HLA-C typing results of 77 sex- and age-matched unrelated non-psoriatic healthy subjects were included. We observed no difference in the allelic distribution of HLA-C between patients and healthy controls, suggesting that none of the HLA-C alleles were significantly associated with psoriasis. Moreover, the HLA-C*07 allele was associated with a late age at disease onset (>30 years old) ( p = 0.007). No statistically significant association was found between HLA-C allele expression and response to MTX, despite a higher frequency of HLA-C*06 in responders compared to non-responders. Thus, HLA-C*07 could be a biomarker of late psoriasis onset in the Moroccan population. Psoriasis still has an unknown etiology. Genetic predisposition shows the association between HLA-Cw6 allele and psoriasis. Although biotherapies have been proven effective in psoriasis treatment, methotrexate (MTX) is still used as a first-line systemic therapy due to its efficacy/affordability, but the differential response to MTX is mostly related to interindividual genetic variability and remains an issue. Our study aimed to analyze HLA-C allele frequencies in a sample of Moroccan psoriatic patients and assess the therapeutic response to MTX. Whole blood of 54 Moroccan psoriatic patients was collected and DNA was extracted. Patients' HLA-C locus was genotyped by PCR-SSO. Results were analyzed with Luminex xMAP Technology and Match-it DNA Evolution 3.4. HLA-C typing results of 77 sex- and age-matched unrelated non-psoriatic healthy subjects were included. We observed no difference in the allelic distribution of HLA-C between patients and healthy controls, suggesting that none of the HLA-C alleles were significantly associated with psoriasis. Moreover, the HLA-C*07 allele was associated with a late age at disease onset (>30 years old) (p = 0.007). No statistically significant association was found between HLA-C allele expression and response to MTX, despite a higher frequency of HLA-C*06 in responders compared to non-responders. Thus, HLA-C*07 could be a biomarker of late psoriasis onset in the Moroccan population.Psoriasis still has an unknown etiology. Genetic predisposition shows the association between HLA-Cw6 allele and psoriasis. Although biotherapies have been proven effective in psoriasis treatment, methotrexate (MTX) is still used as a first-line systemic therapy due to its efficacy/affordability, but the differential response to MTX is mostly related to interindividual genetic variability and remains an issue. Our study aimed to analyze HLA-C allele frequencies in a sample of Moroccan psoriatic patients and assess the therapeutic response to MTX. Whole blood of 54 Moroccan psoriatic patients was collected and DNA was extracted. Patients' HLA-C locus was genotyped by PCR-SSO. Results were analyzed with Luminex xMAP Technology and Match-it DNA Evolution 3.4. HLA-C typing results of 77 sex- and age-matched unrelated non-psoriatic healthy subjects were included. We observed no difference in the allelic distribution of HLA-C between patients and healthy controls, suggesting that none of the HLA-C alleles were significantly associated with psoriasis. Moreover, the HLA-C*07 allele was associated with a late age at disease onset (>30 years old) (p = 0.007). No statistically significant association was found between HLA-C allele expression and response to MTX, despite a higher frequency of HLA-C*06 in responders compared to non-responders. Thus, HLA-C*07 could be a biomarker of late psoriasis onset in the Moroccan population. Psoriasis still has an unknown etiology. Genetic predisposition shows the association between HLA-Cw6 allele and psoriasis. Although biotherapies have been proven effective in psoriasis treatment, methotrexate (MTX) is still used as a first-line systemic therapy due to its efficacy/affordability, but the differential response to MTX is mostly related to interindividual genetic variability and remains an issue. Our study aimed to analyze HLA-C allele frequencies in a sample of Moroccan psoriatic patients and assess the therapeutic response to MTX. Whole blood of 54 Moroccan psoriatic patients was collected and DNA was extracted. Patients' HLA-C locus was genotyped by PCR-SSO. Results were analyzed with Luminex xMAP Technology and Match-it DNA Evolution 3.4. HLA-C typing results of 77 sex- and age-matched unrelated non-psoriatic healthy subjects were included. We observed no difference in the allelic distribution of HLA-C between patients and healthy controls, suggesting that none of the HLA-C alleles were significantly associated with psoriasis. Moreover, the HLA-C*07 allele was associated with a late age at disease onset (>30 years old) ( = 0.007). No statistically significant association was found between HLA-C allele expression and response to MTX, despite a higher frequency of HLA-C*06 in responders compared to non-responders. Thus, HLA-C*07 could be a biomarker of late psoriasis onset in the Moroccan population. |
| Audience | Academic |
| Author | Aazzane, Oussama Admou, Brahim Nassar, Kawtar Sadki, Khalid Fellah, Hassan Chiheb, Soumiya Ettayebi, Hanaa Bennani, Siham Riyad, Myriam Housbane, Samy Benlabsir, Chaimaa Saik, Imane El Idrissi Zaher, Soukaina |
| AuthorAffiliation | 1 Laboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco 7 Oral Biotechnology Laboratory, Fundamental Sciences Department, Faculty of Dental Medicine, Mohammed V University, Rabat 10000, Morocco 5 Laboratory of Immunology, Center of Clinical Research, University Hospital Mohammed VI, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakesh 40000, Morocco 3 Rheumatology Department, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco 4 HLA Typing Laboratory, Pasteur Institute of Morocco, Casablanca 20000, Morocco 2 Laboratory of Immunology, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco 6 Medical Informatics Department, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco 8 Dermatology and Venerology Department, Ibn Rochd University Hospital Center, Casablan |
| AuthorAffiliation_xml | – name: 3 Rheumatology Department, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco – name: 6 Medical Informatics Department, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco – name: 2 Laboratory of Immunology, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco – name: 4 HLA Typing Laboratory, Pasteur Institute of Morocco, Casablanca 20000, Morocco – name: 8 Dermatology and Venerology Department, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco – name: 7 Oral Biotechnology Laboratory, Fundamental Sciences Department, Faculty of Dental Medicine, Mohammed V University, Rabat 10000, Morocco – name: 5 Laboratory of Immunology, Center of Clinical Research, University Hospital Mohammed VI, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakesh 40000, Morocco – name: 1 Laboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco |
| Author_xml | – sequence: 1 givenname: Chaimaa surname: Benlabsir fullname: Benlabsir, Chaimaa – sequence: 2 givenname: Myriam surname: Riyad fullname: Riyad, Myriam – sequence: 3 givenname: Imane El Idrissi orcidid: 0000-0002-8348-0307 surname: Saik fullname: Saik, Imane El Idrissi – sequence: 4 givenname: Hanaa surname: Ettayebi fullname: Ettayebi, Hanaa – sequence: 5 givenname: Oussama surname: Aazzane fullname: Aazzane, Oussama – sequence: 6 givenname: Kawtar surname: Nassar fullname: Nassar, Kawtar – sequence: 7 givenname: Soukaina surname: Zaher fullname: Zaher, Soukaina – sequence: 8 givenname: Siham surname: Bennani fullname: Bennani, Siham – sequence: 9 givenname: Brahim orcidid: 0000-0003-3255-8220 surname: Admou fullname: Admou, Brahim – sequence: 10 givenname: Samy orcidid: 0000-0002-3973-9123 surname: Housbane fullname: Housbane, Samy – sequence: 11 givenname: Khalid orcidid: 0000-0002-9224-5050 surname: Sadki fullname: Sadki, Khalid – sequence: 12 givenname: Soumiya surname: Chiheb fullname: Chiheb, Soumiya – sequence: 13 givenname: Hassan orcidid: 0000-0001-6778-0484 surname: Fellah fullname: Fellah, Hassan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36826011$$D View this record in MEDLINE/PubMed |
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| Snippet | Psoriasis still has an unknown etiology. Genetic predisposition shows the association between HLA-Cw6 allele and psoriasis. Although biotherapies have been... |
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| SubjectTerms | Analysis Development and progression Ethylenediaminetetraacetic acid Genetic aspects Health aspects Histocompatibility antigens HLA histocompatibility antigens HLA-C allele Medical research Medicine, Experimental methotrexate Psoriasis |
| Title | HLA-C Genotyping Reveals Haplotype C07 as a Potential Biomarker of Late Psoriasis Onset in Moroccan Patients |
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