Extracellular adenosine triphosphate is associated with airflow limitation severity and symptoms burden in patients with chronic obstructive pulmonary disease

• Published in: Scientific reports Vol. 9; no. 1; pp. 15349 - 10
• Main Authors: Hlapčić, Iva, Hulina-Tomašković, Andrea, Somborac-Bačura, Anita, Rajković, Marija Grdić, Dugac, Andrea Vukić, Popović-Grle, Sanja, Rumora, Lada
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.10.2019; Nature Publishing Group
• Subjects: 631/45; 631/80; 692/420/256; Adenosine triphosphate; Adenosine Triphosphate - metabolism; Aged; Aged, 80 and over; ATP; Blood; Chronic obstructive pulmonary disease; Extracellular Space - metabolism; Female; Gene expression; Gene Expression Regulation; Gold; Humanities and Social Sciences; Humans; Lung diseases; Male; Middle Aged; multidisciplinary; Obstructive lung disease; Polymerase chain reaction; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - pathology; Pulmonary Disease, Chronic Obstructive - physiopathology; Quality of life; Receptors, Purinergic P2 - genetics; Receptors, Purinergic P2 - metabolism; Respiratory Function Tests; RNA, Messenger - genetics; RNA, Messenger - metabolism; Science; Science (multidisciplinary); Severity of Illness Index; Smoking; Smoking - adverse effects

Extracellular adenosine triphosphate (eATP)-driven inflammation was observed in chronic obstructive pulmonary disease (COPD) but was not investigated in patients’ blood. Therefore, this study aimed to investigate eATP concentration in plasma of COPD patients and its association with disease severity...