The impact of category, cytopathology and cytogenetics on development and progression of clonal and malignant myeloid transformation in inherited bone marrow failure syndromes

• Published in: Haematologica (Roma) Vol. 100; no. 5; pp. 633 - 642
• Main Authors: Cada, Michaela, Segbefia, Catherin I, Klaassen, Robert, Fernandez, Conrad V, Yanofsky, Rochelle A, Wu, John, Pastore, Yves, Silva, Mariana, Lipton, Jeffrey H, Brossard, Josee, Michon, Bruno, Abish, Sharon, Steele, MacGregor, Sinha, Roona, Belletrutti, Mark, Breakey, Vicky, Jardine, Lawrence, Goodyear, Lisa, Sung, Lillian, Shago, Mary, Beyene, Joseph, Sharma, Preeti, Zlateska, Bozana, Dror, Yigal
• Format: Journal Article
• Language: English
• Published: Italy Ferrata Storti Foundation 01.05.2015
• Subjects: Adolescent; Adult; Anemia, Aplastic; Bone Marrow - pathology; Bone Marrow Diseases; Canada - epidemiology; Cell Transformation, Neoplastic - genetics; Child; Child, Preschool; Chromosome Aberrations; Clonal Evolution; Cytogenetic Analysis; Disease Progression; Hemoglobinuria, Paroxysmal - congenital; Hemoglobinuria, Paroxysmal - diagnosis; Hemoglobinuria, Paroxysmal - epidemiology; Humans; Infant; Infant, Newborn; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - epidemiology; Leukemia, Myeloid, Acute - etiology; Patient Outcome Assessment; Prognosis; Registries; Risk; Young Adult

Inherited bone marrow failure syndromes are a group of rare, heterogeneous genetic disorders with a risk of clonal and malignant myeloid transformation including clonal marrow cytogenetic abnormalities, myelodysplastic syndrome and acute myeloid leukemia. The clinical characteristics, risk classific...