Involvement of autophagy and gut dysbiosis in ambient particulate matter-induced colonic inflammation

• Published in: Ecotoxicology and environmental safety Vol. 286; p. 117171
• Main Authors: Cheng, Hsien-Jen, Hsu, Wei-Lun, Lin, Pinpin, Chen, Yu-Cheng, Lin, Tang-Huang, Fang, Shih-Shuan, Tsai, Ming-Hsien, Lin, Yen-Ju, Wang, Shuo-Ping, Chen, Hsin, Jan, Ming-Shiou, Luo, Yueh-Hsia
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.11.2024; Elsevier
• Subjects: Air Pollutants - toxicity; Ambient PM; Animals; Autophagic flux; Autophagy - drug effects; Caco-2 Cells; Colon - drug effects; Colon - pathology; Dysbiosis - chemically induced; Gastrointestinal Microbiome - drug effects; Gut dysbiosis; Humans; Inflammation - chemically induced; Inflammation - pathology; Male; Mice; Mice, Inbred C57BL; Microbiome; Particulate Matter - toxicity; Proliferation; Ambient PM; Gut dysbiosis; Proliferation; Autophagic flux; Microbiome

Ambient fine particulate matter (PM2.5), a vital environmental toxicant, not only adversely affects the cardiovascular and respiratory systems but also potentially exhibits an association with intestinal inflammation and colorectal cancer (CRC). The underlying molecular mechanisms of PM2.5 impacts o...