Impaired ability of Nef to counteract SERINC5 is associated with reduced plasma viremia in HIV-infected individuals

• Published in: Scientific reports Vol. 10; no. 1; p. 19416
• Main Authors: Toyoda, Mako, Kamori, Doreen, Tan, Toong Seng, Goebuchi, Kageaki, Ohashi, Jun, Carlson, Jonathan, Kawana-Tachikawa, Ai, Gatanaga, Hiroyuki, Oka, Shinichi, Pizzato, Massimo, Ueno, Takamasa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.11.2020; Nature Publishing Group
• Subjects: 631/250/255/1901; 631/326/596/1787; 631/326/596/2555; 631/326/596/2557; 631/326/596/2558; CCR5 protein; CD4 antigen; CD4 Antigens - metabolism; Cell Line; Cell-mediated immunity; Cells, Cultured; CXCR4 protein; Genotypes; Histocompatibility antigen HLA; HIV; HIV Infections - metabolism; HIV Infections - pathology; HIV-1 - pathogenicity; HLA-B Antigens - genetics; HLA-B Antigens - metabolism; Human immunodeficiency virus; Humanities and Social Sciences; Humans; Immune Evasion - genetics; Immune Evasion - physiology; Infectivity; Leukocytes, Mononuclear - metabolism; Lymphocytes; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Membrane Proteins - genetics; Membrane Proteins - metabolism; multidisciplinary; Mutation; nef Gene Products, Human Immunodeficiency Virus - genetics; nef Gene Products, Human Immunodeficiency Virus - metabolism; Nef protein; Plasma; Science; Science (multidisciplinary); Viral Load - genetics; Viral Load - physiology; Viremia; Viremia - metabolism; Viremia - virology; Virions; Virus Replication - genetics; Virus Replication - physiology

HIV-1 Nef plays an essential role in enhancing virion infectivity by antagonizing the host restriction molecule SERINC5. Because Nef is highly polymorphic due to the selective forces of host cellular immunity, we hypothesized that certain immune-escape polymorphisms may impair Nef’s ability to antag...