mRNA-lncRNA Co-Expression Network Analysis Reveals the Role of lncRNAs in Immune Dysfunction during Severe SARS-CoV-2 Infection

• Published in: Viruses Vol. 13; no. 3; p. 402
• Main Authors: Mukherjee, Sumit, Banerjee, Bodhisattwa, Karasik, David, Frenkel-Morgenstern, Milana
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 03.03.2021; MDPI AG
• Subjects: Bronchoalveolar Lavage Fluid - immunology; co-expression network; COVID-19; COVID-19 - genetics; COVID-19 - immunology; COVID-19 - virology; COVID-19 infection; cytokine storm; cytokines; Cytokines - genetics; Cytokines - immunology; epithelial cells; Gene Regulatory Networks; Humans; lncRNA; Lung - immunology; Lung - virology; lungs; non-coding RNA; public health; respiratory tract diseases; RNA, Long Noncoding - genetics; RNA, Long Noncoding - immunology; RNA, Messenger - genetics; RNA, Messenger - immunology; SARS-CoV-2 - genetics; SARS-CoV-2 - physiology; Severe acute respiratory syndrome coronavirus 2; transcriptome; viruses; COVID-19; cytokine storm; lncRNA; co-expression network

The recently emerged SARS-CoV-2 virus is responsible for the ongoing COVID-19 pandemic that has rapidly developed into a global public health threat. Patients severely affected with COVID-19 present distinct clinical features, including acute respiratory disorder, neutrophilia, cytokine storm, and s...