Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH

• Published in: Archives of toxicology Vol. 96; no. 1; pp. 287 - 303
• Main Authors: Kermanizadeh, Ali, Valli, Jessica, Sanchez, Katarzyna, Hutter, Simon, Pawlowska, Agnieszka, Whyte, Graeme, Moritz, Wolfgang, Stone, Vicki
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2022; Springer Nature B.V
• Subjects: Animal research; Biocompatibility; Biomedical and Life Sciences; Biomedicine; Detoxification; Endothelial cells; Environmental Health; Experimentation; Fatty liver; Fibrosis; Health risks; Hepatocytes; Hepatotoxicity; In Vitro Systems; Kupffer cells; Liver; Liver diseases; Nanomaterials; Nanotechnology; Occupational Medicine/Industrial Medicine; Particulates; Pharmacology/Toxicology; Risk assessment; Steatosis; Stellate cells; Toxicity; Toxicology; Xenobiotics; In vitro hepatotoxicity; Pre-existing disease state; In vitro vs. in vivo relevance; NASH; 3D primary human quadruple-cell liver microtissue model; Steatosis

In an effort to replace, reduce and refine animal experimentation, there is an unmet need to advance current in vitro models that offer features with physiological relevance and enhanced predictivity of in vivo toxicological output. Hepatic toxicology is key following chemical, drug and nanomaterial...