MRI-guided intrathecal transplantation of hydrogel-embedded glial progenitors in large animals

• Published in: Scientific reports Vol. 8; no. 1; pp. 16490 - 9
• Main Authors: Malysz-Cymborska, Izabela, Golubczyk, Dominika, Kalkowski, Lukasz, Burczyk, Adam, Janowski, Miroslaw, Holak, Piotr, Olbrych, Katarzyna, Sanford, Joanna, Stachowiak, Kalina, Milewska, Kamila, Gorecki, Przemysław, Adamiak, Zbigniew, Maksymowicz, Wojciech, Walczak, Piotr
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.11.2018; Nature Publishing Group
• Subjects: 13; 13/100; 14; 14/34; 59; 59/57; 631/1647/245/1628; 631/378/1689/1285; Amyotrophic lateral sclerosis; Animal diseases; Central nervous system; Glial stem cells; Histopathology; Humanities and Social Sciences; Hyaluronic acid; Hydrogels; Magnetic resonance imaging; Medical instruments; multidisciplinary; Progenitor cells; Science; Science (multidisciplinary); Sedimentation; Spinal cord; Spine; Spine (lumbar); Transplantation; Intrathecal Transplantation; Hydrogel; Degenerative Myelopathy (DM); Intrathecal Space; Polyethylene Glycol Diacrylate

Disseminated diseases of the central nervous system such as amyotrophic lateral sclerosis (ALS) require that therapeutic agents are delivered and distributed broadly. Intrathecal route is attractive in that respect, but to date there was no methodology available allowing for optimization of this tec...