Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

• Published in: Cell reports (Cambridge) Vol. 31; no. 12; p. 107776
• Main Authors: Guttenplan, Kevin A., Stafford, Benjamin K., El-Danaf, Rana N., Adler, Drew I., Münch, Alexandra E., Weigel, Maya K., Huberman, Andrew D., Liddelow, Shane A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.06.2020
• Subjects: Animals; astrocytes; Astrocytes - pathology; astrogliosis; Axons - drug effects; Axons - pathology; Cell Death - drug effects; Cell Shape - drug effects; Complement C1q - metabolism; Dendrites - drug effects; Dendrites - metabolism; Disease Models, Animal; glaucoma; Glaucoma - complications; Glaucoma - pathology; Glaucoma - physiopathology; glia; Gliosis - complications; Gliosis - pathology; Gliosis - physiopathology; Interleukin-1 - metabolism; Intraocular Pressure; Mice, Knockout; Microspheres; neurodegeneration; Neurons - drug effects; Neurons - pathology; neuroprotection; Neurotoxins - toxicity; optic nerve crush; reactive astrocyte; Retina - drug effects; Retina - injuries; Retina - pathology; Retinal Ganglion Cells - drug effects; Retinal Ganglion Cells - pathology; Tumor Necrosis Factor-alpha - metabolism; reactive astrocyte; glaucoma; neuroprotection; neurodegeneration; optic nerve crush; astrocytes; astrogliosis; glia

Glaucoma is a neurodegenerative disease that features the death of retinal ganglion cells (RGCs) in the retina, often as a result of prolonged increases in intraocular pressure. We show that preventing the formation of neuroinflammatory reactive astrocytes prevents the death of RGCs normally seen in...