Age-related impairment of neurovascular coupling responses: a dynamic vessel analysis (DVA)-based approach to measure decreased flicker light stimulus-induced retinal arteriolar dilation in healthy older adults

• Published in: GeroScience Vol. 41; no. 3; pp. 341 - 349
• Main Authors: Lipecz, Agnes, Csipo, Tamas, Tarantini, Stefano, Hand, Rachel A., Ngo, Bich-Thy N., Conley, Shannon, Nemeth, Gabor, Tsorbatzoglou, Alexis, Courtney, Donald L., Yabluchanska, Valeriya, Csiszar, Anna, Ungvari, Zoltan I., Yabluchanskiy, Andriy
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2019; Springer Nature B.V
• Subjects: Adult; Age; Aged; Aging; Aging - physiology; Animal models; Arterioles; Arterioles - physiopathology; Biomedical and Life Sciences; Blood flow; Brain - blood supply; Cell Biology; Cerebral blood flow; Cognitive ability; Cohort Studies; Dementia disorders; Dementia, Vascular - physiopathology; Female; Geriatrics/Gerontology; Humans; Hyperemia; Life Sciences; Male; Microcirculation - physiology; Middle Aged; Molecular Medicine; Neurovascular Coupling - physiology; Older people; Original; Original Article; Photic Stimulation; Reference Values; Retina; Retinal Artery - physiology; Risk factors; Therapeutic applications; Vascular dementia; Vasodilation - physiology; Visual Perception - physiology; Young Adult; Aging; Endothelial dysfunction; Dynamic retinal vessel analysis; Vascular cognitive impairment and dementia; Neurovascular coupling

Aging is a major risk factor for vascular cognitive impairment and dementia (VCID). Recent studies demonstrate that cerebromicrovascular dysfunction plays a causal role in the development of age-related cognitive impairment, in part via disruption of neurovascular coupling (NVC) responses. NVC (func...