Ribosomal DNA transcription in prefrontal pyramidal neurons is decreased in suicide

• Published in: European archives of psychiatry and clinical neuroscience Vol. 270; no. 7; pp. 859 - 867
• Main Authors: Krzyżanowska, Marta, Steiner, Johann, Pieśniak, Dorota, Karnecki, Karol, Kaliszan, Michał, Wiergowski, Marek, Rębała, Krzysztof, Brisch, Ralf, Braun, Katharina, Jankowski, Zbigniew, Kosmowska, Monika, Chociej, Joanna, Gos, Tomasz
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2020; Springer Nature B.V
• Subjects: Cortex (cingulate); Deoxyribonucleic acid; DNA; Emotional behavior; Medicine; Medicine & Public Health; Neurosciences; Original Paper; Paraffin; Pathogenesis; Prefrontal cortex; Protein biosynthesis; Psychiatry; Pyramidal cells; Ribosomal DNA; Statistical analysis; Suicide; Suicides & suicide attempts; Transcription; AgNOR staining; Prefrontal cortex; Suicide; Postmortem

Prefrontal cortical regions, which are crucial for the regulation of emotionally influenced behaviour, play most probably a dominant role in the pathogenesis of suicide. The study was carried out on paraffin-embedded brain tissue blocks containing specimens from the anterior cingulate cortex (dorsal...